Detailed view for TcCLB.511287.90

Basic information

TDR Targets ID: 42638
Trypanosoma cruzi, ribosome biogenesis protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 9.8706 | Length (AA): 303 | MW (Da): 35143 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04427   Brix domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 44 5hmo (A) 820 861 19.00 0.49 0 0.529114 -2.06
40 243 5o9e (A) 74 274 26.00 0 1 1.02177 -0.34
50 234 5by8 (A) 26 236 19.00 0 1 0.786461 -0.47

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127903)

Species Accession Gene Product
Arabidopsis thaliana AT3G15460   ribosomal RNA processing brix domain-containing protein
Arabidopsis thaliana AT1G52930   ribosomal RNA processing Brix domain protein
Babesia bovis BBOV_IV009420   ribosome biogenesis Brix protein, putative
Brugia malayi Bm1_47230   Brix domain containing protein
Candida albicans CaO19.5232   brix domain protein similar to S. cerevisiae BRX1 (YOL077C) nucleolar protein involved in 60S ribosomal subunit biogenesis
Candida albicans CaO19.12697   brix domain protein similar to S. cerevisiae BRX1 (YOL077C) nucleolar protein involved in 60S ribosomal subunit biogenesis
Caenorhabditis elegans CELE_K12H4.3   Protein K12H4.3
Cryptosporidium hominis Chro.40174   ENSANGP00000021112
Cryptosporidium parvum cgd4_1520   Brx1p nucleolar protein required for biogenesis of the 60S ribosomal subunit
Dictyostelium discoideum DDB_G0287937   brix domain-containing protein
Drosophila melanogaster Dmel_CG11583   CG11583 gene product from transcript CG11583-RA
Echinococcus granulosus EgrG_000086700   ribosome biogenesis protein brx1
Entamoeba histolytica EHI_175090   ribosome biogenesis protein, putative
Echinococcus multilocularis EmuJ_000086700   ribosome biogenesis protein brx1
Giardia lamblia GL50803_3589   Ribosome biogenesis protein Brix
Homo sapiens 55299   BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)
Leishmania braziliensis LbrM.20.5830   ribosome biogenesis protein, putative
Leishmania donovani LdBPK_201640.1   ribosome biogenesis protein, putative
Leishmania infantum LinJ.20.1640   ribosome biogenesis protein, putative
Leishmania major LmjF.20.1670   ribosome biogenesis protein, putative
Leishmania mexicana LmxM.20.1670   ribosome biogenesis protein, putative
Loa Loa (eye worm) LOAG_00823   brix domain-containing protein
Mus musculus ENSMUSG00000022247   BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)
Neospora caninum NCLIV_005400   Brx1, related
Oryza sativa 4329832   Os02g0591800
Plasmodium berghei PBANKA_0213500   ribosome biogenesis protein BRX1 homolog, putative
Plasmodium falciparum PF3D7_0729400   ribosome biogenesis protein BRX1 homolog, putative
Plasmodium knowlesi PKNH_0214000   ribosome biogenesis protein BRX1 homolog, putative
Plasmodium vivax PVX_081770   hypothetical protein, conserved
Plasmodium yoelii PY01473   unknown protein, putative
Saccharomyces cerevisiae YOL077C   Brx1p
Schistosoma japonicum Sjp_0099910   Brix domain-containing protein 2, putative
Schistosoma mansoni Smp_156780   ribosome biogenesis protein brix
Schmidtea mediterranea mk4.007085.01   Ribosome biogenesis protein BRX1 homolog
Schmidtea mediterranea mk4.005869.00   Ribosome biogenesis protein brix, putative
Schmidtea mediterranea mk4.007085.00   Ribosome biogenesis protein BRX1 homolog
Schmidtea mediterranea mk4.001834.03   Ribosome biogenesis protein BRX1 homolog
Trypanosoma brucei gambiense Tbg972.10.17840   ribosome biogenesis protein, putative
Trypanosoma brucei Tb927.10.14680   ribosome biogenesis protein, putative
Trypanosoma congolense TcIL3000_10_12550   ribosome biogenesis protein, putative
Trypanosoma cruzi TcCLB.511287.90   ribosome biogenesis protein, putative
Toxoplasma gondii TGME49_222000   brix domain-containing protein
Theileria parva TP01_0829   hypothetical protein, conserved
Trichomonas vaginalis TVAG_000420   ribosome biogenesis protein brix, putative
Trichomonas vaginalis TVAG_498400   ribosome biogenesis protein brix, putative

Essentiality

TcCLB.511287.90 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.14680 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.14680 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.14680 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.14680 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_K12H4.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_K12H4.3 Caenorhabditis elegans larval arrest wormbase
CELE_K12H4.3 Caenorhabditis elegans slow growth wormbase
CELE_K12H4.3 Caenorhabditis elegans sterile wormbase
YOL077C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0213500 Plasmodium berghei Essential plasmo
TGME49_222000 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.511287.90 (Trypanosoma cruzi), ribosome biogenesis protein, putative
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