Detailed view for TcCLB.503593.20

Basic information

TDR Targets ID: 42752
Trypanosoma cruzi, inner dynein arm I1 intermediate chain, axonemal
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.9314 | Length (AA): 810 | MW (Da): 91815 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
384 707 1nex (B) 387 675 18.00 0 1 0.38 0.3
565 744 2aq5 (A) 79 263 18.00 0.0000000038 0.72 0.37 -0.37
549 758 4ycz (A) 45 269 27.00 0.045 0.97 0.414259 0.46
564 639 5nnz (B) 131 206 30.00 0.14 0.92 0.492827 -0.33
565 691 4zoz (A) 63 221 24.00 0.87 0.64 0.42479 -0.3
566 639 4j82 (A) 227 300 19.00 0 0.27 0.321258 -0.41
566 652 3mmy (A) 85 169 34.00 0.0013 0.88 0.522407 -0.33
570 637 4ci8 (A) 374 444 29.00 0.56 0.79 0.432951 -0.26
607 664 4jsn (D) 126 180 35.00 0.66 0.73 0.417605 0.21
611 782 3g4e (A) 11 150 31.00 0.79 0.12 0.0953457 1.13
713 807 4tql (A) 96 193 16.00 0.11 0.04 0.324084 -0.64

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130347)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG14838   CG14838 gene product from transcript CG14838-RA
Echinococcus granulosus EgrG_000099200   Mitochondrial import receptor subunit TOM20
Echinococcus granulosus EgrG_000331000   WD repeat containing protein 63
Echinococcus multilocularis EmuJ_000331000   WD repeat containing protein 63
Echinococcus multilocularis EmuJ_000099200   Mitochondrial import receptor subunit TOM20
Homo sapiens ENSG00000162643   WD repeat domain 63
Leishmania braziliensis LbrM.27.1760   hypothetical protein, conserved
Leishmania donovani LdBPK_271530.1   inner dynein arm I1 intermediate chain, axonemal
Leishmania infantum LinJ.27.1530   hypothetical protein, conserved
Leishmania major LmjF.27.1630   hypothetical protein, conserved
Leishmania mexicana LmxM.27.1630   hypothetical protein, conserved
Mus musculus ENSMUSG00000043020   WD repeat domain 63
Neospora caninum NCLIV_049070   hypothtetical protein, conserved, putative
Plasmodium berghei PBANKA_0520700   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1037800   dynein intermediate chain, putative
Plasmodium knowlesi PKNH_0622300   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_110865   hypothetical protein, conserved
Plasmodium yoelii PY03524   hypothetical protein
Plasmodium yoelii PY03525   hypothetical protein
Schistosoma japonicum Sjp_0094080   similar to Dynein, 70 kDa intermediate chain, flagellar outer arm, putative
Schistosoma japonicum Sjp_0093820   IPR001680,WD-40 repeat;IPR011046,WD40-like,domain-containing
Schistosoma japonicum Sjp_0216660   Mitochondrial import receptor subunit TOM20 homolog, putative
Schistosoma mansoni Smp_136210   testis development protein nyd-sp29
Schmidtea mediterranea mk4.022739.00   Putative testis development protein nyd-sp29
Schmidtea mediterranea mk4.013525.00  
Schmidtea mediterranea mk4.000807.06  
Trypanosoma brucei gambiense Tbg972.11.2520   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.2270   inner dynein arm I1 intermediate chain, axonemal
Trypanosoma congolense TcIL3000.11.2020   inner dynein arm I1 intermediate chain, axonemal
Trypanosoma cruzi TcCLB.503593.20   inner dynein arm I1 intermediate chain, axonemal
Trypanosoma cruzi TcCLB.506127.160   inner dynein arm I1 intermediate chain, axonemal
Toxoplasma gondii TGME49_223262   WD domain, G-beta repeat-containing protein
Trichomonas vaginalis TVAG_299420   testis development protein nyd-sp29, putative

Essentiality

TcCLB.503593.20 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.18.0003 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.18.0003 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.18.0003 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.18.0003 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_223262 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.503593.20 (Trypanosoma cruzi), inner dynein arm I1 intermediate chain, axonemal
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