Detailed view for TcCLB.504151.60

Basic information

TDR Targets ID: 43061
Trypanosoma cruzi, actin interacting protein-like protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.4473 | Length (AA): 518 | MW (Da): 57152 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01565   FAD binding domain
PF02913   FAD linked oxidases, C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016614   oxidoreductase activity, acting on CH-OH group of donors  
GO:0050660   FAD binding  
GO:0016491   oxidoreductase activity  
GO:0003824   catalytic activity  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
22 517 1wvf (A) 11 514 16.00 0 1 1.01 -0.31
32 515 1wvf (A) 18 512 19.00 0 1 1.18 -0.31
38 515 1wvf (A) 23 512 18.00 0 1 1.17 -0.42
23 517 3pm9 (A) 11 475 32.00 0 1 1.3333 -0.44
46 517 3pm9 (A) 26 475 34.00 0 1 1.3149 -0.45
141 248 2gqt (A) 79 173 41.00 0.83 0.41 0.295494 1.08

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote. Smircich P
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_128784)

Species Accession Gene Product
Arabidopsis thaliana AT4G36400   D-2-hydroxyglutarate dehydrogenase
Candida albicans CaO19.300   D-lactate dehydrogenase
Candida albicans CaO19.7932   D-lactate dehydrogenase
Caenorhabditis elegans CELE_F54D5.12   Protein F54D5.12
Dictyostelium discoideum DDB_G0270500   hypothetical protein
Drosophila melanogaster Dmel_CG3835   CG3835 gene product from transcript CG3835-RC
Homo sapiens ENSG00000180902   D-2-hydroxyglutarate dehydrogenase
Leishmania braziliensis LbrM.23.0900   actin interacting protein-like protein
Leishmania donovani LdBPK_230980.1   actin interacting protein-like protein
Leishmania infantum LinJ.23.0980   actin interacting protein-like protein
Leishmania major LmjF.23.0810   actin interacting protein-like protein
Leishmania mexicana LmxM.23.0810   actin interacting protein-like protein
Mycobacterium leprae ML2631c   possible oxidoreductase
Mus musculus ENSMUSG00000073609   D-2-hydroxyglutarate dehydrogenase
Mus musculus 666009   predicted gene 7889
Mycobacterium tuberculosis Rv0161   Possible oxidoreductase
Mycobacterium ulcerans MUL_1038   oxidoreductase
Oryza sativa 4342598   Os07g0187200
Saccharomyces cerevisiae YEL071W   Dld3p
Saccharomyces cerevisiae YDL178W   Dld2p
Schmidtea mediterranea mk4.038005.00   D-2-hydroxyglutarate dehydrogenase, mitochondrial
Schmidtea mediterranea mk4.007793.01   D-2-hydroxyglutarate dehydrogenase, mitochondrial
Schmidtea mediterranea mk4.015011.00  
Schmidtea mediterranea mk4.018804.00  
Schmidtea mediterranea mk4.007793.02   D-2-hydroxyglutarate dehydrogenase, mitochondrial
Schmidtea mediterranea mk4.029572.00  
Trypanosoma cruzi TcCLB.504151.60   actin interacting protein-like protein, putative
Trypanosoma cruzi TcCLB.509461.10   actin interacting protein-like protein, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TcCLB.504151.60 (Trypanosoma cruzi), actin interacting protein-like protein, putative
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