Detailed view for LbrM.17.1530

Basic information

TDR Targets ID: 430611
Leishmania braziliensis, myo-inositol-1(or 4)-monophosphatase 1, putative
Source Database / ID: 

pI: 4.9655 | Length (AA): 282 | MW (Da): 29684 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00459   Inositol monophosphatase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0008934   inositol-1(or 4)-monophosphatase activity  
GO:0046855   inositol phosphate dephosphorylation  
GO:0046854   phosphoinositide phosphorylation  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
12 282 2q74 (A) 5 283 28.00 0 1 1.22959 -0.15
13 279 4as4 (A) 3 267 31.00 0 1 1.41041 -0.9
26 247 2q74 (A) 20 251 35.00 0 1 1.06333 0.45

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126810)

Species Accession Gene Product
Arabidopsis thaliana AT1G31190   myo-inositol monophosphatase like 1
Arabidopsis thaliana AT3G02870   L-galactose-1-phosphate phosphatase
Brugia malayi Bm1_48905   Inositol-1
Caenorhabditis elegans CELE_F13G3.5   Protein TTX-7, isoform B
Dictyostelium discoideum DDB_G0281239   inositol monophosphatase
Drosophila melanogaster Dmel_CG17027   CG17027 gene product from transcript CG17027-RB
Drosophila melanogaster Dmel_CG17026   CG17026 gene product from transcript CG17026-RA
Drosophila melanogaster Dmel_CG9391   CG9391 gene product from transcript CG9391-RC
Drosophila melanogaster Dmel_CG17028   CG17028 gene product from transcript CG17028-RA
Drosophila melanogaster Dmel_CG17029   CG17029 gene product from transcript CG17029-RB
Drosophila melanogaster Dmel_CG9389   CG9389 gene product from transcript CG9389-RA
Escherichia coli b2533   inositol monophosphatase
Echinococcus granulosus EgrG_000451900   inositol monophosphatase 1
Entamoeba histolytica EHI_175410   myo-inositol monophosphatase, putative
Echinococcus multilocularis EmuJ_000451900   inositol monophosphatase 1
Homo sapiens 3612   inositol(myo)-1(or 4)-monophosphatase 1
Homo sapiens ENSG00000141401   inositol(myo)-1(or 4)-monophosphatase 2
Leishmania braziliensis LbrM.17.1530   myo-inositol-1(or 4)-monophosphatase 1, putative
Leishmania donovani LdBPK_171510.1   myo-inositol-1(or 4)-monophosphatase 1, putative
Leishmania infantum LinJ.17.1510   myo-inositol-1(or 4)-monophosphatase 1, putative
Leishmania major LmjF.17.1390   myo-inositol-1(or 4)-monophosphatase 1, putative
Leishmania mexicana LmxM.17.1390   myo-inositol-1(or 4)-monophosphatase 1, putative
Loa Loa (eye worm) LOAG_03630   inositol-1
Mycobacterium leprae ML1024   possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).
Mus musculus 55980   inositol (myo)-1(or 4)-monophosphatase 1
Mus musculus ENSMUSG00000024525   inositol (myo)-1(or 4)-monophosphatase 2
Mycobacterium tuberculosis Rv2701c   Inositol-1-monophosphatase SuhB
Mycobacterium ulcerans MUL_3339   extragenic suppressor protein SuhB
Neospora caninum NCLIV_006000   hypothetical protein
Oryza sativa 4333347   Os03g0587000
Oryza sativa 4328439   Os02g0169900
Saccharomyces cerevisiae YDR287W   inositol monophosphate 1-phosphatase INM2
Saccharomyces cerevisiae YHR046C   inositol monophosphate 1-phosphatase INM1
Schistosoma japonicum Sjp_0211780   ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative
Schistosoma mansoni Smp_095000.1   inositol monophosphatase
Schistosoma mansoni Smp_095000.2   inositol monophosphatase
Schmidtea mediterranea mk4.006138.00   Inositol monophosphatase
Schmidtea mediterranea mk4.002736.02  
Schmidtea mediterranea mk4.018767.00   Inositol monophosphatase ttx-7
Schmidtea mediterranea mk4.002736.01  
Schmidtea mediterranea mk4.012486.00   Inositol monophosphatase ttx-7
Schmidtea mediterranea mk4.010837.00   Inositol monophosphatase
Trypanosoma brucei gambiense Tbg972.5.3780   inositol-1(or 4)-monophosphatase 1, putative
Trypanosoma brucei Tb927.5.2690   inositol-1(or 4)-monophosphatase 1, putative
Trypanosoma congolense TcIL3000_5_2780   inositol-1(or 4)-monophosphatase 1, putative
Trypanosoma cruzi TcCLB.507047.120   myo-inositol-1(or 4)-monophosphatase 1, putative
Trypanosoma cruzi TcCLB.509179.140   myo-inositol-1(or 4)-monophosphatase 1, putative
Toxoplasma gondii TGME49_222970   inositol(myo)-1(or 4)-monophosphatase 2, putative
Trichomonas vaginalis TVAG_144540   inositol monophosphatase, putative
Trichomonas vaginalis TVAG_372100   myo inositol monophosphatase, putative
Trichomonas vaginalis TVAG_051080   myo inositol monophosphatase, putative
Wolbachia endosymbiont of Brugia malayi Wbm0132   fructose-1,6-bisphosphatase

Essentiality

LbrM.17.1530 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.5.2690 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.5.2690 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.5.2690 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.5.2690 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
b2533 Escherichia coli essential goodall
TGME49_222970 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Inositol monophosphatase 1 Compounds References
Bos taurus Inositol-1(or 4)-monophosphatase 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LbrM.17.1530 (Leishmania braziliensis), myo-inositol-1(or 4)-monophosphatase 1, putative
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