Detailed view for LbrM.25.0840

Basic information

TDR Targets ID: 431267
Leishmania braziliensis, gamma-tubulin
Source Database / ID: 

pI: 6.3855 | Length (AA): 447 | MW (Da): 50045 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00091   Tubulin/FtsZ family, GTPase domain
PF03953   Tubulin C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0031122   cytoplasmic microtubule organization and biogenesis  
GO:0007020   microtubule nucleation  
GO:0000930   gamma-tubulin complex  
GO:0005874   microtubule  
GO:0005525   GTP binding  
GO:0003924   GTPase activity  
GO:0007017   microtubule-based process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 444 3cb2 (A) 2 444 67.00 0 1 1.88795 -1.67

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127652)

Species Accession Gene Product
Arabidopsis thaliana AT5G05620   tubulin gamma-2 chain
Arabidopsis thaliana AT3G61650   tubulin gamma-1 chain
Babesia bovis BBOV_IV007250   tubulin gamma chain
Brugia malayi Bm1_55245   Tubulin gamma chain
Candida albicans CaO19.8823   gamma tubulin-like protein
Candida albicans CaO19.1238   gamma tubulin-like protein
Caenorhabditis elegans CELE_F58A4.8   Protein TBG-1
Cryptosporidium hominis Chro.70228   gamma-tubulin
Cryptosporidium parvum cgd7_1980   gamma tubulin
Dictyostelium discoideum DDB_G0271738   gamma tubulin
Drosophila melanogaster Dmel_CG17566   gamma-Tubulin at 37C
Drosophila melanogaster Dmel_CG3157   gamma-Tubulin at 23C
Echinococcus granulosus EgrG_001099700   tubulin gamma 1 chain
Entamoeba histolytica EHI_008240   tubulin gamma chain
Echinococcus multilocularis EmuJ_001099700   tubulin gamma 1 chain
Giardia lamblia GL50803_114218   Gamma tubulin
Homo sapiens ENSG00000131462   tubulin, gamma 1
Homo sapiens ENSG00000037042   tubulin, gamma 2
Leishmania braziliensis LbrM.25.0840   gamma-tubulin
Leishmania donovani LdBPK_250990.1   tubulin gamma chain
Leishmania infantum LinJ.25.0990   gamma-tubulin
Leishmania major LmjF.25.0960   gamma-tubulin
Leishmania mexicana LmxM.25.0960   gamma-tubulin
Loa Loa (eye worm) LOAG_02400   tubulin gamma chain
Mus musculus ENSMUSG00000045007   tubulin, gamma 2
Mus musculus ENSMUSG00000035198   tubulin, gamma 1
Neospora caninum NCLIV_046130   Beta-tubulin, related
Oryza sativa 4337861   Os05g0156600
Plasmodium berghei PBANKA_1226600   tubulin gamma chain, putative
Plasmodium falciparum PF3D7_0803700   tubulin gamma chain
Plasmodium knowlesi PKNH_0115200   tubulin gamma chain, putative
Plasmodium vivax PVX_093560   tubulin gamma chain, putative
Plasmodium yoelii PY00808   tubulin gamma chain
Saccharomyces cerevisiae YLR212C   Tub4p
Schistosoma japonicum Sjp_0036720   ko:K10389 tubulin gamma, putative
Schistosoma mansoni Smp_034670   tubulin subunit gamma
Schmidtea mediterranea mk4.005127.01   Tubulin gamma chain
Schmidtea mediterranea mk4.005127.02   Tubulin gamma chain
Schmidtea mediterranea mk4.005127.00   Tubulin gamma chain
Schmidtea mediterranea mk4.006572.00   Tubulin gamma chain
Trypanosoma brucei gambiense Tbg972.3.550   gamma tubulin
Trypanosoma brucei Tb927.3.910   tubulin gamma chain
Trypanosoma congolense TcIL3000_0_03350   tubulin gamma chain
Trypanosoma cruzi TcCLB.511867.190   tubulin gamma chain
Theileria parva TP03_0233   tubulin gamma chain, putative
Trichomonas vaginalis TVAG_109820   tubulin gamma chain, putative
Trichomonas vaginalis TVAG_369500   tubulin, putative

Essentiality

LbrM.25.0840 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.910 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.3.910 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.3.910 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.3.910 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F58A4.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_F58A4.8 Caenorhabditis elegans sterile wormbase
YLR212C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Leishmania major gamma-tubulin Compounds References
Trypanosoma brucei tubulin gamma chain Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Tubulin beta chain 445 aa 34.2% 438 aa Compounds References
Sus scrofa Tubulin 445 aa 34.2% 438 aa Compounds References
Bos taurus Tubulin 85 aa 39.5% 81 aa Compounds References
Bos taurus Tubulin 445 aa 34.2% 438 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LbrM.25.0840 (Leishmania braziliensis), gamma-tubulin
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