Detailed view for LbrM.19.1800

Basic information

TDR Targets ID: 432462
Leishmania braziliensis, choline/Carnitine o-acyltransferase-like protein
Source Database / ID: 

pI: 8.1019 | Length (AA): 865 | MW (Da): 97247 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00755   Choline/Carnitine o-acyltransferase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016746   transferase activity, transferring acyl groups  

Metabolic Pathways

Fatty acid metabolism (KEGG)
Fatty acid metabolism (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
177 856 2deb (A) 34 652 26.00 0 1 0.947427 -0.22
188 856 2fy2 (A) 9 605 27.00 0 1 0.96991 -0.27
192 848 1nm8 (A) 14 590 31.00 0 1 1.00144 -0.2
444 548 1yck (A) 14 110 33.00 0.96 0.3 0.129287 0.54

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129191)

Species Accession Gene Product
Brugia malayi Bm1_02015   Choline/Carnitine o-acyltransferase family protein
Caenorhabditis elegans CELE_Y46G5A.17   Protein CPT-1
Drosophila melanogaster Dmel_CG12891   withered
Echinococcus granulosus EgrG_000721500   carnitine O palmitoyltransferase 1 liver
Echinococcus multilocularis EmuJ_000721500   carnitine O palmitoyltransferase 1, liver
Homo sapiens ENSG00000205560   carnitine palmitoyltransferase 1B (muscle)
Homo sapiens ENSG00000169169   carnitine palmitoyltransferase 1C
Homo sapiens ENSG00000110090   carnitine palmitoyltransferase 1A (liver)
Leishmania braziliensis LbrM.19.1800   choline/Carnitine o-acyltransferase-like protein
Leishmania donovani LdBPK_191570.1   choline/Carnitine o-acyltransferase-like protein
Leishmania infantum LinJ.19.1570   choline/Carnitine o-acyltransferase-like protein
Leishmania major LmjF.19.1540   choline/Carnitine o-acyltransferase-like protein
Leishmania mexicana LmxM.19.1540   choline/Carnitine o-acyltransferase-like protein
Loa Loa (eye worm) LOAG_06041   hypothetical protein
Mus musculus ENSMUSG00000024900   carnitine palmitoyltransferase 1a, liver
Mus musculus ENSMUSG00000078937   carnitine palmitoyltransferase 1b, muscle
Mus musculus ENSMUSG00000007783   carnitine palmitoyltransferase 1c
Schmidtea mediterranea mk4.020197.01  
Schmidtea mediterranea mk4.004183.01   Peroxisomal carnitine O-octanoyltransferase
Schmidtea mediterranea mk4.003010.04  
Schmidtea mediterranea mk4.020197.00   LD31742p
Schmidtea mediterranea mk4.000720.06  
Schmidtea mediterranea mk4.001768.02  
Schmidtea mediterranea mk4.001768.00  
Schmidtea mediterranea mk4.003010.03  
Schmidtea mediterranea mk4.016069.00  
Schmidtea mediterranea mk4.003010.05  
Schmidtea mediterranea mk4.003010.01   LD31742p
Schmidtea mediterranea mk4.001768.03  
Schmidtea mediterranea mk4.055407.00  
Schmidtea mediterranea mk4.007161.00  
Schmidtea mediterranea mk4.014696.01  
Schmidtea mediterranea mk4.000720.07  
Trypanosoma cruzi TcCLB.507211.10   choline/carnitine O-acyltransferase, putative
Trypanosoma cruzi TcCLB.511353.4   choline/carnitine O-acyltransferase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Carnitine palmitoyltransferase 1A Compounds References
Rattus norvegicus Carnitine palmitoyltransferase 1B Compounds References
Sus scrofa Carnitine palmitoyltransferase 1A Compounds References
Homo sapiens carnitine palmitoyltransferase 1A (liver) Compounds References
Homo sapiens carnitine palmitoyltransferase 1B (muscle) Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Carnitine palmitoyltransferase 2 658 aa 25.9% 673 aa Compounds References
Rattus norvegicus Choline acetylase 640 aa 25.7% 685 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LbrM.19.1800 (Leishmania braziliensis), choline/Carnitine o-acyltransferase-like protein
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