Detailed view for TcCLB.503745.20

Basic information

TDR Targets ID: 43398
Trypanosoma cruzi, Cleft lip and palate transmembrane protein 1 (CLPTM1), putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.0091 | Length (AA): 588 | MW (Da): 68345 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 5

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05602   Cleft lip and palate transmembrane protein 1 (CLPTM1)

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0016020   membrane  
GO:0003824   catalytic activity  
GO:0006915   apoptosis  
GO:0005975   carbohydrate metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
108 330 1yo8 (A) 959 1171 12.00 0 0.03 0.23 -0.25

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_127427)

Species Accession Gene Product
Arabidopsis thaliana AT5G23575   transmembrane CLPTM1 family protein
Arabidopsis thaliana AT5G08500   transmembrane CLPTM1 family protein
Babesia bovis BBOV_IV011540   transmembrane CLPTM1 family protein
Brugia malayi Bm1_42235   cisplatin
Brugia malayi Bm1_06285   cleft lip and palate associated transmembrane protein 1
Caenorhabditis elegans CELE_T13H5.8   Protein T13H5.8
Caenorhabditis elegans CELE_C36B7.6   Protein C36B7.6
Caenorhabditis elegans CELE_R166.2   Protein R166.2
Cryptosporidium hominis Chro.70367   strong similar to -related
Cryptosporidium parvum cgd7_3290   cleft lip and palate family of eukaryotic membrane proteins (potential transporters) with 9 transmembrane domains
Dictyostelium discoideum DDB_G0283115   cleft lip and palate transmembrane 1 family protein
Drosophila melanogaster Dmel_CG3702   CG3702 gene product from transcript CG3702-RA
Drosophila melanogaster Dmel_CG4332   CG4332 gene product from transcript CG4332-RA
Echinococcus granulosus EgrG_000836900   cleft lip and palate transmembrane protein
Echinococcus granulosus EgrG_000456700   Cleft lip and palate transmembrane protein 1
Entamoeba histolytica EHI_130850   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000836900   cleft lip and palate transmembrane protein
Echinococcus multilocularis EmuJ_000456700   Cleft lip and palate transmembrane protein 1
Homo sapiens ENSG00000049656   CLPTM1-like
Homo sapiens ENSG00000104853   cleft lip and palate associated transmembrane protein 1
Leishmania braziliensis LbrM.20.0130   hypothetical protein, conserved
Leishmania donovani LdBPK_340050.1   Cleft lip and palate transmembrane protein 1 (CLPTM1), putative
Leishmania infantum LinJ.34.0050   hypothetical protein, conserved
Leishmania major LmjF.34.0050   hypothetical protein, conserved
Leishmania mexicana LmxM.33.0050   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_01087   cisplatin
Loa Loa (eye worm) LOAG_08433   hypothetical protein
Loa Loa (eye worm) LOAG_15076   hypothetical protein
Mus musculus ENSMUSG00000021610   CLPTM1-like
Mus musculus ENSMUSG00000002981   cleft lip and palate associated transmembrane protein 1
Neospora caninum NCLIV_020430   hypothetical protein
Oryza sativa 4335933   Os04g0441900
Onchocerca volvulus OVOC5403   Cleft lip and palate transmembrane protein 1 homolog
Plasmodium berghei PBANKA_0911400   CLPTM1 domain-containing protein, putative
Plasmodium falciparum PF3D7_1137300   CLPTM1 domain-containing protein, putative
Plasmodium knowlesi PKNH_0935500   CLPTM1 domain-containing protein, putative
Plasmodium vivax PVX_092480   hypothetical protein, conserved
Plasmodium yoelii PY01217   strong similarity to unknown protein-related
Schistosoma japonicum Sjp_0205000   Cleft lip and palate transmembrane protein 1 homolog, putative
Schistosoma japonicum Sjp_0302340   Cleft lip and palate transmembrane protein 1-like protein, putative
Schistosoma mansoni Smp_175170   cleft lip and palate associated transmembrane protein-related
Schistosoma mansoni Smp_145250   hypothetical protein
Schmidtea mediterranea mk4.002766.01   Cleft lip and palate transmembrane protein 1
Schmidtea mediterranea mk4.000115.01  
Trypanosoma brucei gambiense Tbg972.10.3060   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.2470   Cleft lip and palate transmembrane protein 1 (CLPTM1), putative
Trypanosoma congolense TcIL3000_10_2100   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.503745.20   Cleft lip and palate transmembrane protein 1 (CLPTM1), putative
Trypanosoma cruzi TcCLB.506193.20   Cleft lip and palate transmembrane protein 1 (CLPTM1), putative
Toxoplasma gondii TGME49_205240   cleft lip and palate transmembrane protein 1 (clptm1) protein
Theileria parva TP01_1151   hypothetical protein
Trichomonas vaginalis TVAG_515920   conserved hypothetical protein
Trichomonas vaginalis TVAG_413020   conserved hypothetical protein
Trichomonas vaginalis TVAG_248720   conserved hypothetical protein

Essentiality

TcCLB.503745.20 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.2470 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.2470 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.2470 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.2470 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0911400 Plasmodium berghei Slow plasmo
TGME49_205240 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TcCLB.503745.20 (Trypanosoma cruzi), Cleft lip and palate transmembrane protein 1 (CLPTM1), putative
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