Detailed view for LbrM.24.0680

Basic information

TDR Targets ID: 433986
Leishmania braziliensis, protein kinase, putative
Source Database / ID: 

pI: 7.3301 | Length (AA): 1240 | MW (Da): 130887 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
31 435 4yhj (A) 102 453 19.00 0 0.9 0.253041 0.97
111 477 3nie (A) 25 413 19.00 0 1 0.167698 0.53
115 445 2vd5 (A) 70 363 24.00 0 0.76 0.208898 0.6
218 432 2h34 (A) 118 276 41.00 0.029 0.71 -0.127877 1.31
297 430 5lqf (A) 144 286 29.00 0 1 0.239575 -0.01
346 444 3npc (A) 209 334 27.00 0 1 0.173548 -0.42
847 1029 3go6 (A) 34 230 30.00 0.035 0.37 0.122413 1.12
943 1062 2mqa (A) 18 136 12.00 0 0.01 0.251364 -0.91

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_148668)

Species Accession Gene Product
Leishmania braziliensis LbrM.24.0680   protein kinase, putative
Leishmania donovani LdBPK_240680.1   protein kinase, putative
Leishmania infantum LinJ.24.0680   protein kinase, putative
Leishmania major LmjF.24.0670   protein kinase, putative
Leishmania mexicana LmxM.24.0670   protein kinase, putative
Trypanosoma brucei gambiense Tbg972.11.6020   protein kinase, putative
Trypanosoma brucei Tb927.11.5340   Cell division protein kinase, putative
Trypanosoma congolense TcIL3000.11.5580   Cell division protein kinase, putative
Trypanosoma cruzi TcCLB.504125.90   Cell division protein kinase, putative
Trypanosoma cruzi TcCLB.505183.140   Cell division protein kinase, putative

Essentiality

LbrM.24.0680 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.3010 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.3010 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb11.02.3010 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.3010 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus c-Jun N-terminal kinase 3 464 aa 22.9% 401 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 24.1% 295 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 24.9% 217 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 24.8% 290 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 19.2% 308 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 23.8% 307 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 25.3% 296 aa Compounds References
Patiria pectinifera Cdc2 300 aa 21.5% 289 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LbrM.24.0680 (Leishmania braziliensis), protein kinase, putative
Title for this comment
Comment