Detailed view for TcCLB.509157.220

Basic information

TDR Targets ID: 43591
Trypanosoma cruzi, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 10.8213 | Length (AA): 102 | MW (Da): 10502 | Paralog Number: 1

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 3

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03647   Transmembrane proteins 14C

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 37 2yz1 (A) 24 58 46.00 0.7 0.06 0.624337 1.74

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote. Smircich P
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_128377)

Species Accession Gene Product
Arabidopsis thaliana AT1G50740   transmembrane protein 14C
Arabidopsis thaliana AT3G20510   transmembrane protein 14C
Arabidopsis thaliana AT3G43520   transmembrane protein 14C
Arabidopsis thaliana AT2G26240   transmembrane protein 14C
Brugia malayi Bm1_49095   Transmembrane protein 14C
Candida albicans CaO19.6318   similar to S. cerevisiae YJR085C
Candida albicans CaO19.13695   similar to S. cerevisiae YJR085C
Dictyostelium discoideum DDB_G0271790   transmembrane protein 14 B
Dictyostelium discoideum DDB_G0288759   transmembrane protein 14 A
Drosophila melanogaster Dmel_CG5532   CG5532 gene product from transcript CG5532-RB
Echinococcus granulosus EgrG_000189250   expressed conserved protein
Echinococcus multilocularis EmuJ_000189250   expressed conserved protein
Homo sapiens ENSG00000111843   transmembrane protein 14C
Homo sapiens ENSG00000096092   transmembrane protein 14A
Loa Loa (eye worm) LOAG_09337   hypothetical protein
Mus musculus ENSMUSG00000021361   transmembrane protein 14C
Mus musculus ENSMUSG00000025933   transmembrane protein 14A
Neospora caninum NCLIV_045310   hypothetical protein, conserved
Oryza sativa 4333277   Os03g0568500
Oryza sativa 4337241   Os04g0653100
Onchocerca volvulus OVOC852   UPF0136 membrane protein CG5532 homolog
Saccharomyces cerevisiae YJR085C   hypothetical protein
Schmidtea mediterranea mk4.000543.06  
Trypanosoma brucei gambiense Tbg972.11.16930   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.509157.220   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.510725.40   hypothetical protein, conserved
Toxoplasma gondii TGME49_228110   hypothetical protein

Essentiality

TcCLB.509157.220 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_228110 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.509157.220 (Trypanosoma cruzi), hypothetical protein, conserved
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