Detailed view for LinJ.10.0940

Basic information

TDR Targets ID: 436512
Leishmania infantum, FKBP-type peptidyl-prolyl cis-trans isomerase, putative
Source Database / ID: 

pI: 9.611 | Length (AA): 159 | MW (Da): 17352 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00254   FKBP-type peptidyl-prolyl cis-trans isomerase

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 155 1jvw (A) 37 189 42.00 0 1 1.53135 -1.17
28 134 2ppn (A) 1 106 40.00 0 1 1.24876 -1.38
30 134 5i98 (A) 7 121 45.00 0 1 1.11618 -0.64
41 136 2pbc (A) 41 138 43.00 0 1 1.22307 -1.17

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128118)

Species Accession Gene Product
Arabidopsis thaliana AT3G25220   peptidyl-prolyl cis-trans isomerase FKBP15-1
Arabidopsis thaliana AT5G48580   peptidyl-prolyl cis-trans isomerase FKBP15-2
Brugia malayi Bm1_37310   FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13
Caenorhabditis elegans CELE_F36H1.1   Protein FKB-1, isoform B
Cryptosporidium hominis Chro.60310   peptidyl-prolyl isomerase/macrophage infectivity potentiator
Cryptosporidium parvum cgd6_2690   macrophage infectivity potentiator (MIP);FKBP peptidyl-prolyl cis-trans isomerase-like fold, signal peptide + ER retention motif
Dictyostelium discoideum DDB_G0282267   FKBP-type peptidylprolyl cis-trans isomerase
Drosophila melanogaster Dmel_CG14715   CG14715 gene product from transcript CG14715-RA
Escherichia coli b4207   FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase)
Echinococcus granulosus EgrG_000699500   FK506 binding protein 2
Entamoeba histolytica EHI_012390   peptidyl-prolyl cis-trans isomerase, putative
Echinococcus multilocularis EmuJ_000699500  
Homo sapiens ENSG00000173486   FK506 binding protein 2, 13kDa
Leishmania braziliensis LbrM.10.0990   FKBP-type peptidyl-prolyl cis-trans isomerase, putative
Leishmania donovani LdBPK_100940.1   FKBP-type peptidyl-prolyl cis-trans isomerase, putative
Leishmania infantum LinJ.10.0940   FKBP-type peptidyl-prolyl cis-trans isomerase, putative
Leishmania major LmjF.10.0890   FKBP-type peptidyl-prolyl cis-trans isomerase, putative
Leishmania mexicana LmxM.10.0890   FKBP-type peptidyl-prolyl cis-trans isomerase, putative
Loa Loa (eye worm) LOAG_01463   FKBP-type peptidyl-prolyl cis-trans isomerase-13
Mus musculus ENSMUSG00000056629   FK506 binding protein 2
Mycobacterium ulcerans MUL_2208   hypothetical protein
Neospora caninum NCLIV_011240   FKBP-type peptidyl-prolyl cis-trans isomerase FklB, related
Oryza sativa 9269317   Os09g0501850
Oryza sativa 4324328   Os01g0915800
Saccharomyces cerevisiae YDR519W   peptidylprolyl isomerase family protein FPR2
Schmidtea mediterranea mk4.001154.05   FKBP2
Schmidtea mediterranea mk4.006563.00   Peptidyl-prolyl cis-trans isomerase
Trypanosoma brucei gambiense Tbg972.10.19020   FKBP-type peptidyl-prolyl cis-trans isomerase, putative,FKBP-type peptidylprolyl cis-trans isomerase, putative
Trypanosoma brucei Tb927.10.15590   macrophage infectivity potentiator, precursor, putative
Trypanosoma congolense TcIL3000_10_13370   macrophage infectivity potentiator, precursor, putative
Trypanosoma cruzi TcCLB.508897.110   macrophage infectivity potentiator, precursor, putative

Essentiality

LinJ.10.0940 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.15590 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.15590 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.15590 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.15590 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b4207 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Gallus gallus FK506 binding protein 12 108 aa 45.1% 91 aa Compounds References
Rattus norvegicus FK506-binding protein 1A 108 aa 40.8% 103 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LinJ.10.0940 (Leishmania infantum), FKBP-type peptidyl-prolyl cis-trans isomerase, putative
Title for this comment
Comment