pI: 8.7878 |
Length (AA): 508 |
MW (Da): 57226 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 222 | 4w4t (A) | 1209 | 1395 | 33.00 | 0.00000011 | 0.76 | 0.532171 | 1 |
243 | 297 | 4fe8 (C) | 361 | 410 | 46.00 | 0.072 | 0.16 | 0.472368 | 0.05 |
275 | 308 | 5d60 (A) | 173 | 206 | 26.00 | 0 | 0.5 | 0.680129 | -3.28 |
277 | 306 | 3jsv (D) | 310 | 339 | 20.00 | 0 | 0.03 | 0.544255 | -3.07 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | epimastigote. | Smircich P |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | metacyclic. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_127504)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G11980 | fatty acyl-CoA reductase 2 |
Arabidopsis thaliana | AT3G44550 | fatty acyl-CoA reductase 5 |
Arabidopsis thaliana | AT3G44560 | fatty acyl-CoA reductase 8 |
Arabidopsis thaliana | AT3G44540 | fatty acyl-CoA reductase 4 |
Arabidopsis thaliana | AT4G33790 | fatty acyl-CoA reductase CER4 |
Arabidopsis thaliana | AT5G22500 | fatty acyl-CoA reductase 1 |
Arabidopsis thaliana | AT3G56700 | fatty acyl-CoA reductase 6 |
Brugia malayi | Bm1_37285 | Male sterility protein |
Caenorhabditis elegans | CELE_Y71H10A.2 | Protein FARD-1 |
Dictyostelium discoideum | DDB_G0289081 | hypothetical protein |
Drosophila melanogaster | Dmel_CG12268 | CG12268 gene product from transcript CG12268-RB |
Drosophila melanogaster | Dmel_CG5065 | CG5065 gene product from transcript CG5065-RA |
Drosophila melanogaster | Dmel_CG1443 | waterproof |
Homo sapiens | ENSG00000197601 | fatty acyl CoA reductase 1 |
Homo sapiens | ENSG00000064763 | fatty acyl CoA reductase 2 |
Leishmania braziliensis | LbrM.24.1700 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_241710.1 | Male sterility protein, putative |
Leishmania infantum | LinJ.24.1710 | hypothetical protein, conserved |
Leishmania major | LmjF.24.1640 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.24.1640 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_07175 | male sterility protein |
Mus musculus | ENSMUSG00000030759 | fatty acyl CoA reductase 1 |
Mus musculus | ENSMUSG00000030303 | fatty acyl CoA reductase 2 |
Neospora caninum | NCLIV_021430 | hypothetical protein |
Oryza sativa | 4335559 | Os04g0353600 |
Oryza sativa | 4335561 | Os04g0354400 |
Oryza sativa | 4331746 | Os03g0167600 |
Oryza sativa | 4335562 | Os04g0354600 |
Schmidtea mediterranea | mk4.025342.00 | |
Schmidtea mediterranea | mk4.004374.05 | |
Trypanosoma brucei gambiense | Tbg972.8.6810 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.8.6640 | Male sterility protein, putative |
Trypanosoma congolense | TcIL3000_0_09330 | Male sterility protein, putative |
Trypanosoma cruzi | TcCLB.510721.10 | Male sterility protein, putative |
Trypanosoma cruzi | TcCLB.511909.10 | Male sterility protein, putative |
Toxoplasma gondii | TGME49_203580 | NAD-binding domain 4 domain-containing protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.6640 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.6640 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.6640 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.6640 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_203580 | Toxoplasma gondii | Probably non-essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.