pI: 6.0313 |
Length (AA): 318 |
MW (Da): 35031 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 317 | 1nex (B) | 371 | 702 | 24.00 | 0 | 1 | 1.2 | 0.26 |
8 | 313 | 2h14 (A) | 40 | 331 | 30.00 | 0 | 1 | 1.29 | -0.47 |
63 | 314 | 2h14 (A) | 41 | 288 | 32.00 | 0 | 1 | 1.23 | -0.79 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | epimastigote, metacyclic. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_127516)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G18130 | receptor for activated C kinase 1C |
Arabidopsis thaliana | AT1G18080 | guanine nucleotide-binding protein subunit beta-like protein A |
Arabidopsis thaliana | AT1G48630 | receptor for activated C kinase 1B |
Babesia bovis | BBOV_II003050 | receptor for activated C kinase, RACK protein |
Brugia malayi | Bm1_36465 | activated protein kinase C receptor RACK1 - rat, putative |
Candida albicans | CaO19_6906 | hypothetical protein |
Candida albicans | CaO19.6906 | G-beta-like protein |
Caenorhabditis elegans | CELE_K04D7.1 | Protein RACK-1 |
Cryptosporidium hominis | Chro.20203 | guanine nucleotide-binding protein |
Cryptosporidium parvum | cgd2_1870 | guanine nucleotide-binding protein, putative |
Dictyostelium discoideum | DDB_G0275045 | hypothetical protein |
Drosophila melanogaster | Dmel_CG7111 | Receptor of activated protein kinase C 1 |
Echinococcus granulosus | EgrG_001132500 | guanine nucleotide binding protein subunit |
Entamoeba histolytica | EHI_050550 | guanine nucleotide-binding protein subunit beta 2-like 1, putative |
Entamoeba histolytica | EHI_110400 | guanine nucleotide-binding protein subunit beta 2-like 1, putative |
Entamoeba histolytica | EHI_171280 | guanine nucleotide-binding protein subunit beta 2-like 1, putative |
Echinococcus multilocularis | EmuJ_001132500 | guanine nucleotide binding protein subunit |
Homo sapiens | ENSG00000204628 | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 |
Leishmania braziliensis | LbrM.28.2950 | activated protein kinase c receptor (LACK),guanine nucleotide-binding protein beta subunit- like protein |
Leishmania donovani | LdBPK_282970.1 | activated protein kinase c receptor (LACK) |
Leishmania infantum | LinJ.28.2970 | activated protein kinase c receptor (LACK) |
Leishmania infantum | LinJ.28.2940 | activated protein kinase c receptor (LACK) |
Leishmania major | LmjF.28.2750 | activated protein kinase c receptor (LACK),guanine nucleotide-binding protein beta subunit- like protein |
Leishmania major | LmjF.28.2740 | activated protein kinase c receptor (LACK),guanine nucleotide-binding protein beta subunit- like protein |
Leishmania mexicana | LmxM.28.2740 | activated protein kinase c receptor (LACK),guanine nucleotide-binding protein beta subunit- like protein |
Leishmania mexicana | LmxM.28.2740a | |
Loa Loa (eye worm) | LOAG_04975 | activated protein kinase C receptor RACK1 |
Mus musculus | ENSMUSG00000020372 | guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 |
Neospora caninum | NCLIV_059430 | hypothetical protein |
Oryza sativa | 4324115 | Os01g0686800 |
Oryza sativa | 4339539 | Os05g0552300 |
Plasmodium berghei | PBANKA_0703900 | receptor for activated c kinase, putative |
Plasmodium falciparum | PF3D7_0826700 | receptor for activated c kinase |
Plasmodium knowlesi | PKNH_1320900 | receptor for activated c kinase, putative |
Plasmodium vivax | PVX_089025 | receptor for activated c kinase, putative |
Plasmodium yoelii | PY00516 | hypothetical protein |
Saccharomyces cerevisiae | YMR116C | guanine nucleotide-binding protein subunit beta |
Schistosoma japonicum | Sjp_0015980 | ko:K00567 methylated-DNA-[protein]-cysteine S-methyltransferase [EC2.1.1.63], putative |
Schistosoma mansoni | Smp_102040.3 | receptor for activated PKC |
Schistosoma mansoni | Smp_102040.1 | receptor for activated PKC |
Schistosoma mansoni | Smp_102040.2 | receptor for activated PKC |
Schmidtea mediterranea | mk4.000213.11 | Guanine nucleotide-binding protein subunit beta-2-like 1 |
Trypanosoma brucei gambiense | Tbg972.11.12690 | guanine nucleotide-binding protein beta subunit-like protein,activated protein kinase c receptor |
Trypanosoma brucei | Tb927.11.11370 | receptor for activated C kinase 1 |
Trypanosoma brucei | Tb927.11.11360 | receptor for activated C kinase 1 |
Trypanosoma congolense | TcIL3000.11.12030 | receptor for activated C kinase 1 |
Trypanosoma cruzi | TcCLB.511211.120 | receptor for activated C kinase 1, putative |
Trypanosoma cruzi | TcCLB.511211.130 | receptor for activated C kinase 1, putative |
Toxoplasma gondii | TGME49_216880 | guanine nucleotide-binding protein |
Theileria parva | TP04_0288 | guanine nucleotide-binding protein, putative |
Trichomonas vaginalis | TVAG_429360 | WD repeat domain, putative |
Trichomonas vaginalis | TVAG_145570 | receptor for activated protein kinase C, putative |
Trichomonas vaginalis | TVAG_151920 | WD repeat domain, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.3170 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.3170 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.3170 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.3170 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_K04D7.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K04D7.1 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_K04D7.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_K04D7.1 | Caenorhabditis elegans | sterile | wormbase |
TGME49_216880 | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.