Detailed view for PF3D7_0603400

Basic information

TDR Targets ID: 4388
Plasmodium falciparum, trophozoite exported protein 1
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 5.4442 | Length (AA): 1103 | MW (Da): 132471 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13920   Zinc finger, C3HC4 type (RING finger)

Gene Ontology

Mouse over links to read term descriptions.
GO:0008270   zinc ion binding  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 182 4uy3 (A) 25 215 13.00 0.91 0.02 0.194298 -0.01
250 1042 3v0a (B) 4 927 24.00 0.074 0.95 0.614448 1.74
745 951 4tql (A) 11 233 28.00 0.003 0.58 0.42317 -0.53
817 1003 4uos (A) 1 184 25.00 1 0.64 0.467038 -0.99
846 1089 3t6p (A) 410 606 28.00 0.28 0.6 0.165715 1.1
1034 1102 4r7e (A) 632 700 41.00 0.00011 1 0.540057 0.17
747 953 4tql (A) 11 233 28.00 0.003 0.58 0.42223 -0.53
826 1005 4uos (A) 4 184 21.00 0.21 1 0.488996 -1.01
848 1091 3t6p (A) 410 606 28.00 0.28 0.6 0.164714 1.1
999 1097 4ayc (A) 351 447 23.00 0.16 0.93 0.343693 -0.06
1036 1104 4r7e (A) 632 700 41.00 0.00011 1 0.539343 0.17

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Sporozoite, Male Gametocyte. Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Oocyst, Ring. Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, Female Gametocyte. Otto TD Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 48 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 40 hs. Otto TD
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_128069)

Species Accession Gene Product
Arabidopsis thaliana AT1G55250   E3 ubiquitin-protein ligase HUB2
Arabidopsis thaliana AT2G44950   E3 ubiquitin-protein ligase BRE1-like 1
Babesia bovis BBOV_III010000   hypothetical protein
Brugia malayi Bm1_13375   RE34950p
Brugia malayi Bm1_54905   RING finger protein 20
Candida albicans CaO19.976   Putative coiled-coil protein
Candida albicans CaO19.8591   Putative coiled-coil protein
Caenorhabditis elegans CELE_R05D3.4   Protein RFP-1, isoform B
Cryptosporidium hominis Chro.20099   hypothetical protein
Cryptosporidium parvum cgd2_880   hypothetical protein
Dictyostelium discoideum DDB_G0274241   RING zinc finger-containing protein
Drosophila melanogaster Dmel_CG10542   CG10542 gene product from transcript CG10542-RB
Echinococcus granulosus EgrG_001044600   ribosomal protein s6 kinase beta 1
Echinococcus granulosus EgrG_001178400   Ribosomal protein S6 kinase beta 2
Echinococcus granulosus EgrG_001044900   E3 ubiquitin protein ligase Bre1
Echinococcus multilocularis EmuJ_001044600   ribosomal protein s6 kinase beta 1
Echinococcus multilocularis EmuJ_001178400   Ribosomal protein S6 kinase beta 2
Echinococcus multilocularis EmuJ_001044900   E3 ubiquitin protein ligase Bre1
Homo sapiens ENSG00000155827   ring finger protein 20, E3 ubiquitin protein ligase
Homo sapiens ENSG00000103549   ring finger protein 40, E3 ubiquitin protein ligase
Loa Loa (eye worm) LOAG_02911   RING finger protein 20
Mus musculus ENSMUSG00000028309   ring finger protein 20
Mus musculus ENSMUSG00000030816   ring finger protein 40
Neospora caninum NCLIV_059210   hypothetical protein
Oryza sativa 4349420   Os10g0565600
Plasmodium berghei PBANKA_0102200   trophozoite exported protein 1, putative
Plasmodium falciparum PF3D7_0603400   trophozoite exported protein 1
Plasmodium knowlesi PKNH_1147300   trophozoite exported protein 1, putative
Plasmodium vivax PVX_113335   trophozoite exported protein 1, putative
Plasmodium yoelii PY02581   hypothetical protein
Saccharomyces cerevisiae YDL074C   E3 ubiquitin-protein ligase BRE1
Schistosoma japonicum Sjp_0133950   E3 ubiquitin-protein ligase BRE1B, putative
Schistosoma japonicum Sjp_0048140   ko:K04688 p70 ribosomal S6 kinase, putative
Schistosoma mansoni Smp_136750   serine/threonine protein kinase
Schmidtea mediterranea mk4.010169.02   E3 ubiquitin-protein ligase bre-1
Schmidtea mediterranea mk4.000297.11   E3 ubiquitin-protein ligase bre-1
Schmidtea mediterranea mk4.005144.00   Serine/threonine kinase
Toxoplasma gondii TGME49_217220   zinc finger, C3HC4 type (RING finger) domain-containing protein
Theileria parva TP02_0149   hypothetical protein

Essentiality

PF3D7_0603400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_R05D3.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_R05D3.4 Caenorhabditis elegans larval arrest wormbase
CELE_R05D3.4 Caenorhabditis elegans larval lethal wormbase
CELE_R05D3.4 Caenorhabditis elegans slow growth wormbase
CELE_R05D3.4 Caenorhabditis elegans sterile wormbase
PBANKA_0102200 Plasmodium berghei Dispensable plasmo
TGME49_217220 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_0603400 (Plasmodium falciparum), trophozoite exported protein 1
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