pI: 10.943 |
Length (AA): 190 |
MW (Da): 21281 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
7 | 190 | 1iqv (A) | 19 | 218 | 39.00 | 0 | 1 | 1.38 | -0.46 |
48 | 189 | 1hus () | 15 | 147 | 32.00 | 0 | 1 | 1.07 | -0.75 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | epimastigote. | Smircich P |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | metacyclic. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_127064)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G11940 | 40S ribosomal protein S5A |
Arabidopsis thaliana | AT2G37270 | 40S ribosomal protein S5-1 |
Babesia bovis | BBOV_I000230 | 40S ribosomal protein S5, putative |
Brugia malayi | Bm1_27835 | 40S ribosomal protein S5 |
Candida albicans | CaO19.11812 | likely cytosolic ribosomal protein similar to S. cerevisiae RPS5 (YJR123W) small subunit protein S5 |
Candida albicans | CaO19.4336 | likely cytosolic ribosomal protein similar to S. cerevisiae RPS5 (YJR123W) small subunit protein S5 |
Caenorhabditis elegans | CELE_T05E11.1 | Protein RPS-5 |
Cryptosporidium hominis | Chro.60495 | ribosomal protein S5 |
Cryptosporidium parvum | cgd6_4320 | 40S ribosomal protein S5 |
Dictyostelium discoideum | DDB_G0286075 | 40S ribosomal protein S5 |
Drosophila melanogaster | Dmel_CG8922 | Ribosomal protein S5a |
Drosophila melanogaster | Dmel_CG7014 | Ribosomal protein S5b |
Echinococcus granulosus | EgrG_000228600 | ribosomal protein |
Entamoeba histolytica | EHI_126110 | 40S ribosomal protein S5 |
Entamoeba histolytica | EHI_200850 | 40S ribosomal protein S5 |
Entamoeba histolytica | EHI_137870 | 40S ribosomal protein S5 |
Entamoeba histolytica | EHI_044590 | 40S ribosomal protein S5 |
Echinococcus multilocularis | EmuJ_000228600 | ribosomal protein |
Giardia lamblia | GL50803_12981 | Ribosomal protein S5 |
Homo sapiens | ENSG00000083845 | ribosomal protein S5 |
Leishmania braziliensis | LbrM.11.0760 | 40S ribosomal protein S5 |
Leishmania infantum | LinJ.11.0960 | 40S ribosomal protein S5 |
Leishmania major | LmjF.11.0960 | 40S ribosomal protein S5 |
Leishmania major | LmjF.11.0970 | 40S ribosomal protein S5 |
Leishmania mexicana | LmxM.11.0970 | 40S ribosomal protein S5 |
Leishmania mexicana | LmxM.11.0960 | 40S ribosomal protein S5 |
Loa Loa (eye worm) | LOAG_02133 | 40S ribosomal protein S5 |
Mus musculus | ENSMUSG00000012848 | ribosomal protein S5 |
Neospora caninum | NCLIV_017500 | hypothetical protein |
Oryza sativa | 4350516 | Os11g0482000 |
Oryza sativa | 4326457 | Os01g0100700 |
Plasmodium berghei | PBANKA_0619100 | 40S ribosomal protein S5, putative |
Plasmodium falciparum | PF3D7_0721600 | 40S ribosomal protein S5, putative |
Plasmodium knowlesi | PKNH_0317000 | 40S ribosomal protein S5, putative |
Plasmodium vivax | PVX_096265 | 40S ribosomal protein S5, putative |
Plasmodium yoelii | PY06068 | ribosomal protein S7 |
Saccharomyces cerevisiae | YJR123W | ribosomal 40S subunit protein S5 |
Schistosoma japonicum | Sjp_0025220 | ko:K02989 small subunit ribosomal protein S5e, putative |
Schistosoma mansoni | Smp_093440 | 40S ribosomal protein S5 |
Schmidtea mediterranea | mk4.007539.00 | 40S ribosomal protein S5 |
Schmidtea mediterranea | mk4.003201.00 | 40S ribosomal protein S5 |
Trypanosoma brucei gambiense | Tbg972.11.7110 | 40S ribosomal protein S5, putative |
Trypanosoma brucei gambiense | Tbg972.11.7100 | 40S ribosomal protein S5, putative |
Trypanosoma brucei | Tb927.11.6300 | 40S ribosomal protein S5, putative |
Trypanosoma congolense | TcIL3000.11.6840 | 40S ribosomal protein S5, putative |
Trypanosoma congolense | TcIL3000.11.6850 | 40S ribosomal protein S5, putative |
Trypanosoma congolense | TcIL3000_0_41060 | 40S ribosomal protein S5, putative |
Trypanosoma cruzi | TcCLB.510101.170 | 40S ribosomal protein S5, putative |
Trypanosoma cruzi | TcCLB.510101.180 | 40S ribosomal protein S5, putative |
Trypanosoma cruzi | TcCLB.506297.150 | 40S ribosomal protein S5, putative |
Trypanosoma cruzi | TcCLB.506297.160 | 40S ribosomal protein S5, putative |
Toxoplasma gondii | TGME49_242330 | ribosomal protein RPS5 |
Theileria parva | TP03_0860 | 40S ribosomal protein S5, putative |
Trichomonas vaginalis | TVAG_163450 | 30S ribosomal protein S7p, putative |
Trichomonas vaginalis | TVAG_471390 | 40S ribosomal protein S5, putative |
Trichomonas vaginalis | TVAG_163210 | 40S ribosomal protein S5, putative |
Trichomonas vaginalis | TVAG_163440 | 40S ribosomal protein S5, putative |
Trichomonas vaginalis | TVAG_246200 | ribosomal protein S7, putative |
Trichomonas vaginalis | TVAG_163180 | 40S ribosomal protein S5, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.4170 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.4170 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.4170 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.4170 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T05E11.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T05E11.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T05E11.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T05E11.1 | Caenorhabditis elegans | sterile | wormbase |
YJR123W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0619100 | Plasmodium berghei | Essential | plasmo |
TGME49_242330 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.