Detailed view for TcCLB.511293.40

Basic information

TDR Targets ID: 43942
Trypanosoma cruzi, U3 snoRNA-associated protein UTP11, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 11.0905 | Length (AA): 452 | MW (Da): 51612 | Paralog Number: 1

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03998   Utp11 protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0032040   small subunit processome  
GO:0006364   rRNA processing  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
404 450 1gl2 (D) 155 202 15.00 0.000000054 0 0.32 -1.05
126 440 3edv (A) 1697 2011 12.00 0 0.98 0.821003 -0.01
311 452 5cwj (A) 22 161 15.00 0 0.28 0.502259 -0.89
368 451 2l3l (A) 26 129 29.00 0.29 0.42 0.220941 -0.18
381 450 5izs (A) 9 78 13.00 0.96 0.01 0.415967 -1.85

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128132)

Species Accession Gene Product
Arabidopsis thaliana AT3G60360   putative U3 small nucleolar RNA-associated protein 11
Babesia bovis BBOV_I004420   conserved hypothetical protein
Brugia malayi Bm1_53765   Utp11 protein
Candida albicans CaO19.2386   similar to S. cerevisiae YKL099C
Candida albicans CaO19.9922   similar to S. cerevisiae YKL099C
Caenorhabditis elegans CELE_C16C10.2   Protein C16C10.2
Cryptosporidium hominis Chro.10073   hypothetical protein
Cryptosporidium hominis Chro.10072   hypothetical protein
Cryptosporidium parvum cgd1_610   hypothetical protein
Dictyostelium discoideum DDB_G0270230   U3 small nucleolar ribonucleoprotein
Drosophila melanogaster Dmel_CG1789   CG1789 gene product from transcript CG1789-RA
Echinococcus granulosus EgrG_001127600   Proto oncogene tyrosine protein kinase FYN
Entamoeba histolytica EHI_122830   U3 small nucleolar RNA-associated protein 11, putative
Echinococcus multilocularis EmuJ_001127600   Proto oncogene tyrosine protein kinase FYN
Giardia lamblia GL50803_1894   U3 small nucleolar RNA-associated protein 11, putative
Homo sapiens ENSG00000183520   UTP11-like, U3 small nucleolar ribonucleoprotein (yeast)
Leishmania braziliensis LbrM.19.0990   U3 snoRNA-associated protein UTP11, putative
Leishmania donovani LdBPK_190670.1   U3 snoRNA-associated protein UTP11, putative
Leishmania infantum LinJ.19.0670   U3 snoRNA-associated protein UTP11, putative
Leishmania major LmjF.19.0670   U3 snoRNA-associated protein UTP11, putative
Leishmania mexicana LmxM.19.0670   U3 snoRNA-associated protein UTP11, putative
Loa Loa (eye worm) LOAG_08979   hypothetical protein
Loa Loa (eye worm) LOAG_06414   Utp11 protein
Mus musculus 67205   UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
Neospora caninum NCLIV_035500   hypothetical protein, conserved
Oryza sativa 4327566   Os01g0810000
Plasmodium berghei PBANKA_1460800   nucleolar rRNA processing protein, putative
Plasmodium falciparum PF3D7_1247900   nucleolar rRNA processing protein, putative
Plasmodium knowlesi PKNH_1467600   u3 small nucleolar rna-associated protein, putative
Plasmodium vivax PVX_101285   U3 small nucleolar RNA-associated protein 11, putative
Plasmodium yoelii PY01569   Arabidopsis thaliana At3g60360/T8B10_20, putative
Saccharomyces cerevisiae YKL099C   Utp11p
Schistosoma mansoni Smp_026190   hypothetical protein
Trypanosoma brucei gambiense Tbg972.10.18780   U3 snoRNA-associated protein UTP11, putative
Trypanosoma brucei Tb11.v5.0481   U3 snoRNA-associated protein UTP11, putative
Trypanosoma congolense TcIL3000_10_13160   U3 snoRNA-associated protein UTP11, putative
Trypanosoma cruzi TcCLB.511293.40   U3 snoRNA-associated protein UTP11, putative
Trypanosoma cruzi TcCLB.506503.100   U3 snoRNA-associated protein UTP11, putative
Toxoplasma gondii TGME49_271390   hypothetical protein
Theileria parva TP01_0183   hypothetical protein
Trichomonas vaginalis TVAG_040320   conserved hypothetical protein

Essentiality

TcCLB.511293.40 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.15380 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.15380 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.15380 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.15380 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C16C10.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_C16C10.2 Caenorhabditis elegans larval arrest wormbase
CELE_C16C10.2 Caenorhabditis elegans larval lethal wormbase
CELE_C16C10.2 Caenorhabditis elegans slow growth wormbase
CELE_C16C10.2 Caenorhabditis elegans sterile wormbase
YKL099C Saccharomyces cerevisiae inviable yeastgenome
TGME49_271390 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TcCLB.511293.40 (Trypanosoma cruzi), U3 snoRNA-associated protein UTP11, putative
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