Detailed view for TcCLB.503579.110

Basic information

TDR Targets ID: 44010
Trypanosoma cruzi, pseudouridylate synthase I, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.1612 | Length (AA): 655 | MW (Da): 73058 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01416   tRNA pseudouridine synthase

Gene Ontology

Mouse over links to read term descriptions.
GO:0009982   pseudouridine synthase activity  
GO:0003723   RNA binding  
GO:0009451   RNA modification  
GO:0001522   pseudouridine synthesis  

Metabolic Pathways

Pyrimidine metabolism (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
23 391 1dj0 (A) 11 257 26.00 0 0.72 0.27 1.01
18 447 4iqm (A) 82 395 29.00 0 1 0.491689 1.1
26 418 4j37 (A) 88 367 36.00 0.000000006 1 0.392 1.49
447 620 4uos (A) 2 180 13.00 0.019 0 0.370849 -0.4

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_146749)

Species Accession Gene Product
Leishmania braziliensis LbrM.26.0440   pseudouridylate synthase-like protein
Leishmania donovani LdBPK_260410.1   pseudouridylate synthase-like protein
Leishmania infantum LinJ.26.0410   pseudouridylate synthase-like protein
Leishmania major LmjF.26.0420   pseudouridylate synthase-like protein
Leishmania mexicana LmxM.26.0420   pseudouridylate synthase-like protein
Trypanosoma brucei gambiense Tbg972.7.1510   pseudouridylate synthase I, putative
Trypanosoma brucei Tb927.7.1510   pseudouridylate synthase I, putative
Trypanosoma congolense TcIL3000_7_1020   pseudouridylate synthase I, putative
Trypanosoma cruzi TcCLB.507517.100   pseudouridylate synthase I, putative
Trypanosoma cruzi TcCLB.503579.110   pseudouridylate synthase I, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.503579.110 (Trypanosoma cruzi), pseudouridylate synthase I, putative
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