pI: 6.2737 |
Length (AA): 635 |
MW (Da): 68847 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
26 | 625 | 4jne (A) | 1 | 604 | 53.00 | 0 | 1 | 1.58498 | -0.71 |
29 | 402 | 4kbo (A) | 55 | 428 | 68.00 | 0 | 1 | 1.46248 | -1.1 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126744)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G37910 | heat shock protein 70-1 |
Arabidopsis thaliana | AT5G49910 | heat shock protein 70-2 |
Arabidopsis thaliana | AT5G09590 | mitochondrial HSO70 2 |
Arabidopsis thaliana | AT4G24280 | chloroplast heat shock protein 70-1 |
Babesia bovis | BBOV_IV003490 | heat shock protein 70 |
Brugia malayi | Bm1_51555 | Heat shock 70 kDa protein F, mitochondrial precursor, putative |
Candida albicans | CaO19.7179 | heat shock protein |
Candida albicans | CaO19_7179 | hypothetical protein |
Candida albicans | CaO19.9452 | Mitochondrial import protein (DnaK) |
Candida albicans | CaO19.1896 | Mitochondrial import protein (DnaK) |
Caenorhabditis elegans | CELE_C37H5.8 | Protein HSP-6 |
Cryptosporidium hominis | Chro.30389 | dnaK-type molecular chaperone hsp70, organellar |
Cryptosporidium parvum | cgd3_3440 | heat shock protein HSP70, mitochondrial |
Chlamydia trachomatis | CT_396 | chaperone protein DnaK |
Dictyostelium discoideum | DDB_G0293298 | hypothetical protein |
Drosophila melanogaster | Dmel_CG8542 | Heat shock protein cognate 5 |
Escherichia coli | b0014 | chaperone Hsp70, with co-chaperone DnaJ |
Echinococcus granulosus | EgrG_000909900 | stress 70 protein mitochondrial |
Echinococcus granulosus | EgrG_001065400 | heat shock protein 70 |
Entamoeba histolytica | EHI_013760 | heat shock protein 70, mitochondrial, putative |
Entamoeba histolytica | EHI_101120 | heat shock protein 70, mitochondrial, putative |
Entamoeba histolytica | EHI_071800 | heat shock protein70, mitochondrial, putative |
Entamoeba histolytica | EHI_007150 | mitochondrial-type heat shock protein 70 |
Entamoeba histolytica | EHI_127700 | heat shock protein 70, mitochondrial, putative |
Echinococcus multilocularis | EmuJ_001065400 | heat shock protein 70 |
Echinococcus multilocularis | EmuJ_000909900 | heat shock 70 kDa protein, mitochondrial precursor, putative |
Homo sapiens | ENSG00000113013 | heat shock 70kDa protein 9 (mortalin) |
Leishmania braziliensis | LbrM.30.2420 | heat shock 70-related protein 1, mitochondrial precursor, putative |
Leishmania braziliensis | LbrM.30.2440 | heat shock 70-related protein 1, mitochondrial precursor, putative |
Leishmania infantum | LinJ.30.2470 | heat shock 70-related protein 1, mitochondrial precursor, putative |
Leishmania infantum | LinJ.30.2480 | heat shock 70-related protein 1, mitochondrial precursor, putative |
Leishmania infantum | LinJ.30.2540 | heat shock 70-related protein 1, mitochondrial precursor, putative |
Leishmania infantum | LinJ.30.2530 | heat shock 70-related protein 1, mitochondrial precursor, putative |
Leishmania major | LmjF.30.2550 | heat shock 70-related protein 1, mitochondrial precursor, putative |
Leishmania major | LmjF.30.2490 | heat shock 70-related protein 1, mitochondrial precursor, putative |
Leishmania major | LmjF.30.2470 | heat shock 70-related protein 1, mitochondrial precursor, putative |
Leishmania major | LmjF.30.2460 | heat shock 70-related protein 1, mitochondrial precursor, putative |
Leishmania major | LmjF.30.2480 | heat shock 70-related protein 1, mitochondrial precursor, putative |
Leishmania mexicana | LmxM.29.2490 | heat shock 70-related protein 1, mitochondrial precursor, putative |
Leishmania mexicana | LmxM.29.2460 | heat shock 70-related protein 1, mitochondrial precursor, putative |
Leishmania mexicana | LmxM.29.2550 | heat shock 70-related protein 1, mitochondrial precursor, putative |
Leishmania mexicana | LmxM.29.2470 | heat shock 70-related protein 1, mitochondrial precursor, putative |
Loa Loa (eye worm) | LOAG_00057 | hypothetical protein |
Loa Loa (eye worm) | LOAG_00058 | hypothetical protein |
Mycobacterium leprae | ML2496c | PROBABLE CHAPERONE PROTEIN DNAK (HEAT SHOCK PROTEIN 70) (HEAT SHOCK 70 KDA PROTEIN) (HSP70) |
Mus musculus | ENSMUSG00000024359 | heat shock protein 9 |
Mycobacterium tuberculosis | Rv0350 | Probable chaperone protein DnaK (heat shock protein 70) (heat shock 70 kDa protein) (HSP70) |
Mycobacterium ulcerans | MUL_3422 | chaperone protein DnaK1 |
Mycobacterium ulcerans | MUL_0593 | molecular chaperone DnaK |
Neospora caninum | NCLIV_066840 | hypothetical protein |
Oryza sativa | 4331379 | Os03g0113700 |
Oryza sativa | 4338354 | Os05g0303000 |
Oryza sativa | 4351875 | Os12g0244100 |
Oryza sativa | 9270165 | Os09g0491772 |
Oryza sativa | 4330888 | Os02g0774300 |
Onchocerca volvulus | OVOC6877 | Heat shock 70 kDa protein F, mitochondrial homolog |
Onchocerca volvulus | OVOC12759 |
|
Plasmodium berghei | PBANKA_0914400 | heat shock protein 70, putative |
Plasmodium falciparum | PF3D7_1134000 | heat shock protein 70 |
Plasmodium knowlesi | PKNH_0932200 | heat shock protein 70, putative |
Plasmodium vivax | PVX_092310 | heat shock protein 70, putative |
Plasmodium yoelii | PY06981 | heat shock protein hsp70 homologue Pfhsp70-3 |
Saccharomyces cerevisiae | YEL030W | Hsp70 family ATPase ECM10 |
Saccharomyces cerevisiae | YJR045C | Hsp70 family ATPase SSC1 |
Saccharomyces cerevisiae | YLR369W | Hsp70 family ATPase SSQ1 |
Schistosoma japonicum | Sjp_0026230 | ko:K04043 molecular chaperone DnaK, putative |
Schistosoma mansoni | Smp_106130.2 | heat shock protein 70 |
Schistosoma mansoni | Smp_106130.1 | heat shock protein 70 |
Trypanosoma brucei gambiense | Tbg972.6.3520 | heat shock 70 kDa protein, mitochondrial precursor, putative |
Trypanosoma brucei gambiense | Tbg972.6.3510 | heat shock 70 kDa protein, mitochondrial precursor, putative |
Trypanosoma brucei gambiense | Tbg972.6.3580 | heat shock 70 kDa protein, mitochondrial precursor, putative |
Trypanosoma brucei | Tb927.6.3800 | heat shock 70 kDa protein, mitochondrial precursor, putative |
Trypanosoma brucei | Tb927.6.3740 | heat shock 70 kDa protein, mitochondrial precursor, putative |
Trypanosoma brucei | Tb927.6.3750 | heat shock 70 kDa protein, mitochondrial precursor, putative |
Trypanosoma congolense | TcIL3000_0_08300 | heat shock 70 kDa protein, putative |
Trypanosoma congolense | TcIL3000_0_27070 | heat shock 70 kDa protein, putative |
Trypanosoma cruzi | TcCLB.507029.30 | heat shock 70 kDa protein, mitochondrial precursor, putative |
Toxoplasma gondii | TGME49_251780 | heat shock protein |
Treponema pallidum | TP0216 | molecular chaperone DnaK |
Theileria parva | TP02_0753 | heat shock protein 70, putative |
Trichomonas vaginalis | TVAG_237140 | heat shock protein, putative |
Trichomonas vaginalis | TVAG_340390 | heat shock protein 70 (HSP70)-4, putative |
Trichomonas vaginalis | TVAG_433130 | heat shock protein, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0495 | molecular chaperone DnaK |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu353 | Mycobacterium tuberculosis | essential | nmpdr |
Tb927.6.3740 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.3740 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.3740 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.6.3740 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C37H5.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C37H5.8 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C37H5.8 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C37H5.8 | Caenorhabditis elegans | sterile | wormbase |
YJR045C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_251780 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Escherichia coli | chaperone Hsp70, with co-chaperone DnaJ | Compounds | References |