pI: 5.4129 |
Length (AA): 219 |
MW (Da): 26035 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 14 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
109 | 216 | 1z7p (A) | 3 | 108 | 21.00 | 0 | 1 | 0.94 | -2.19 |
114 | 219 | 1wik (A) | 2 | 107 | 42.00 | 0 | 1 | 1.09 | -1.78 |
118 | 212 | 2fls (A) | 18 | 110 | 17.00 | 0 | 1 | 0.87 | -2.58 |
115 | 214 | 3gx8 (A) | 33 | 135 | 44.00 | 0 | 1 | 1.13182 | -1.71 |
117 | 214 | 2wci (A) | 5 | 102 | 42.00 | 0 | 1 | 1.15369 | -1.92 |
118 | 212 | 2yan (A) | 237 | 331 | 49.00 | 0 | 1 | 1.19699 | -1.79 |
175 | 217 | 2mmz (A) | 101 | 143 | 44.00 | 0.000022 | 0.53 | 0.585447 | 0.83 |
184 | 216 | 1kte (A) | 70 | 102 | 30.00 | 0.0067 | 0.66 | 0.459085 | 0.41 |
184 | 214 | 3uiw (A) | 82 | 112 | 29.00 | 0.0027 | 0.92 | 0.526953 | -0.2 |
100 | 216 | 2lku (A) | 4 | 107 | 40.00 | 0 | 1 | 0.878447 | -0.4 |
100 | 215 | 2yan (A) | 232 | 334 | 46.00 | 0 | 1 | 0.92388 | -0.4 |
114 | 215 | 3ipz (A) | 69 | 170 | 42.00 | 0.000000000061 | 1 | 1.14325 | -1.72 |
119 | 213 | 3zyw (A) | 136 | 230 | 44.00 | 0 | 1 | 1.15699 | -1.89 |
179 | 213 | 3ctg (A) | 105 | 139 | 34.00 | 0.0054 | 0.55 | 0.508117 | 0.25 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs. | Otto TD |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst, Ring, Female Gametocyte. | Otto TD Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Sporozoite. | Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Male Gametocyte. | Lasonder E |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Ortholog group members (OG5_127633)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G04950 | monothiol glutaredoxin-S17 |
Babesia bovis | BBOV_II007430 | thioredoxin-like protein 2 |
Babesia bovis | BBOV_II007360 | Thioredoxin-like protein 2 |
Brugia malayi | Bm1_51225 | glutaredoxin-related protein |
Candida albicans | CaO19.10241 | potential thioredoxin similar to S. cerevisiae GRX3 (YDR098C) glutaredoxin |
Candida albicans | CaO19.2727 | potential thioredoxin similar to S. cerevisiae GRX3 (YDR098C) glutaredoxin |
Caenorhabditis elegans | CELE_D2063.3 | Protein GLRX-3, isoform A |
Cryptosporidium hominis | Chro.60457 | thioredoxin-like protein |
Cryptosporidium parvum | cgd6_3970 | glutaredoxin-like protein; 2 thioredoxin folds |
Dictyostelium discoideum | DDB_G0275555 | glutaredoxin family protein |
Drosophila melanogaster | Dmel_CG6523 | CG6523 gene product from transcript CG6523-RA |
Echinococcus granulosus | EgrG_000195300 | glutaredoxin 3 |
Echinococcus multilocularis | EmuJ_000195300 | glutaredoxin 3 |
Homo sapiens | ENSG00000108010 | glutaredoxin 3 |
Leishmania braziliensis | LbrM.34.1170 | thioredoxin-like protein |
Leishmania braziliensis | LbrM.05.0310 | glutaredoxin-like protein |
Leishmania donovani | LdBPK_050320.1 | glutaredoxin-like protein |
Leishmania donovani | LdBPK_351260.1 | thioredoxin-like protein |
Leishmania infantum | LinJ.05.0320 | glutaredoxin-like protein |
Leishmania infantum | LinJ.35.1260 | thioredoxin-like protein |
Leishmania major | LmjF.05.0310 | glutaredoxin-like protein |
Leishmania major | LmjF.35.1250 | thioredoxin-like protein |
Leishmania mexicana | LmxM.05.0310 | glutaredoxin-like protein |
Leishmania mexicana | LmxM.34.1250 | thioredoxin-like protein |
Loa Loa (eye worm) | LOAG_00884 | hypothetical protein |
Mus musculus | ENSMUSG00000031068 | glutaredoxin 3 |
Neospora caninum | NCLIV_015460 | hypothetical protein |
Oryza sativa | 4349034 | Os10g0500700 |
Plasmodium berghei | PBANKA_0105500 | glutaredoxin-like protein |
Plasmodium falciparum | PF3D7_0606900 | glutaredoxin-like protein |
Plasmodium knowlesi | PKNH_1143400 | glutaredoxin-like protein |
Plasmodium vivax | PVX_113510 | glutaredoxin-like protein, putative |
Plasmodium yoelii | PY00223 | glutaredoxin-related protein |
Saccharomyces cerevisiae | YER174C | monothiol glutaredoxin GRX4 |
Saccharomyces cerevisiae | YDR098C | monothiol glutaredoxin GRX3 |
Schistosoma japonicum | Sjp_0038240 | ko:K07390 monothiol glutaredoxin, putative |
Schistosoma mansoni | Smp_006550.2 | glutaredoxin grx |
Schmidtea mediterranea | mk4.000927.01 | Glutaredoxin-3 |
Trypanosoma brucei gambiense | Tbg972.10.12710 | monothiol glutaredoxin, putative |
Trypanosoma brucei gambiense | Tbg972.5.1310 | thioredoxin-like protein |
Trypanosoma brucei | Tb927.10.10420 | monothiol glutaredoxin, putative |
Trypanosoma brucei | Tb927.5.950 | monothiol glutaredoxin, putative |
Trypanosoma congolense | TcIL3000_0_47240 | monothiol glutaredoxin, putative |
Trypanosoma congolense | TcIL3000_5_680 | monothiol glutaredoxin, putative |
Trypanosoma cruzi | TcCLB.508303.65 | thioredoxin-like protein, putative |
Trypanosoma cruzi | TcCLB.503425.20 | monothiol glutaredoxin, putative |
Trypanosoma cruzi | TcCLB.511179.100 | monothiol glutaredoxin, putative |
Toxoplasma gondii | TGME49_238070 | glutaredoxin domain-containing protein |
Theileria parva | TP02_0196 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.950 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.950 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.950 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.5.950 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.10.10420 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.10420 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.10420 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.10420 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_0105500 | Plasmodium berghei | Slow | plasmo |
TGME49_238070 | Toxoplasma gondii | Essentiality uncertain | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.