Detailed view for PF3D7_0607400

Basic information

TDR Targets ID: 4428
Plasmodium falciparum, G-protein associated signal transduction protein, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.2582 | Length (AA): 633 | MW (Da): 76180 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 10

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03124   EXS family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
93 260 4zbw (A) 28 176 31.00 0.34 0.23 0.359103 0.92
205 361 3b4r (A) 61 200 30.00 0.63 0.07 0.161725 2.56

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Male Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Sporozoite, Female Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Oocyst, Ring. Zanghi G
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_127625)

Species Accession Gene Product
Arabidopsis thaliana AT3G29060   EXS (ERD1/XPR1/SYG1) family protein
Arabidopsis thaliana AT1G26730   phosphate transporter PHO1-7
Arabidopsis thaliana AT1G68740   H1
Arabidopsis thaliana AT1G69480   EXS (ERD1/XPR1/SYG1) family protein
Arabidopsis thaliana AT4G25350   protein SHORT HYPOCOTYL UNDER BLUE1
Arabidopsis thaliana AT3G23430   phosphate transporter PHO1
Arabidopsis thaliana AT1G14040   phosphate transporter PHO1-3
Arabidopsis thaliana AT2G03240   EXS (ERD1/XPR1/SYG1) family protein
Arabidopsis thaliana AT1G35350   phosphate transporter PHO1-8
Arabidopsis thaliana AT2G03250   phosphate transporter PHO1-like 6
Arabidopsis thaliana AT2G03260   phosphate transporter PHO1-like 2
Babesia bovis BBOV_II007270   EXS family protein
Brugia malayi Bm1_29055   EXS family protein
Candida albicans CaO19.768   membrane transporter, suppressor of GPA1 deficiency
Candida albicans CaO19.8389   membrane transporter, suppressor of GPA1 deficiency
Caenorhabditis elegans CELE_Y39A1A.22   Protein Y39A1A.22
Cryptosporidium hominis Chro.80350   hypothetical protein
Cryptosporidium parvum cgd8_3000   SYG1/ ERD1 like integral membrane protein required for retention of ER lumen proteins, with 8-10 transmembrane domains
Dictyostelium discoideum DDB_G0290647   EXS domain-containing protein
Dictyostelium discoideum DDB_G0285957   EXS domain-containing protein
Dictyostelium discoideum DDB_G0271664   EXS domain-containing protein
Drosophila melanogaster Dmel_CG10483   CG10483 gene product from transcript CG10483-RA
Drosophila melanogaster Dmel_CG7536   CG7536 gene product from transcript CG7536-RC
Echinococcus granulosus EgrG_000247400   xenotropic and polytropic retrovirus receptor 1
Entamoeba histolytica EHI_092090   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000247400   xenotropic and polytropic retrovirus receptor 1
Giardia lamblia GL50803_16516   Xenotropic and polytropic murine leukemia virus receptor
Homo sapiens ENSG00000143324   xenotropic and polytropic retrovirus receptor 1
Loa Loa (eye worm) LOAG_08492   EXS family protein
Mus musculus ENSMUSG00000026469   xenotropic and polytropic retrovirus receptor 1
Neospora caninum NCLIV_064730   hypothetical protein
Oryza sativa 9270401   Os01g0110100
Oryza sativa 4341088   Os06g0493600
Oryza sativa 4331090   Os02g0809800
Plasmodium berghei PBANKA_0106000   G-protein associated signal transduction protein, putative
Plasmodium falciparum PF3D7_0607400   G-protein associated signal transduction protein, putative
Plasmodium knowlesi PKNH_1142900   EXS family protein, putative
Plasmodium vivax PVX_113535   hypothetical protein, conserved
Plasmodium yoelii PY02530   hypothetical protein
Saccharomyces cerevisiae YIL047C   Syg1p
Schistosoma japonicum Sjp_0082580   Xenotropic and polytropic retrovirus receptor 1 homolog, putative
Schistosoma mansoni Smp_141100   xenotropic and polytropic murine leukemia virus receptor xpr1
Theileria parva TP02_0183   hypothetical protein

Essentiality

PF3D7_0607400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y39A1A.22 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y39A1A.22 Caenorhabditis elegans slow growth wormbase
PBANKA_0106000 Plasmodium berghei Dispensable plasmo
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0607400 (Plasmodium falciparum), G-protein associated signal transduction protein, putative
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