pI: 7.0104 |
Length (AA): 746 |
MW (Da): 84547 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
58 | 746 | 1v7w (A) | 90 | 727 | 12.00 | 0 | 0.91 | 0.73 | 0.36 |
329 | 744 | 1gai () | 3 | 428 | 10.00 | 0 | 0.2 | 0.26 | -0.22 |
1 | 746 | 4j5t (A) | 16 | 801 | 23.00 | 0 | 1 | 1.131 | 0.18 |
2 | 742 | 4j5t (A) | 17 | 797 | 24.00 | 0 | 1 | 1.1453 | 0.22 |
379 | 743 | 2z07 (A) | 36 | 420 | 16.00 | 0 | 0.92 | 0.638276 | -0.14 |
416 | 530 | 1y1x (A) | 34 | 151 | 31.00 | 0.56 | 0.6 | 0.409155 | 0.29 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | epimastigote, metacyclic. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_129620)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G67490 | alpha-glucosidase I |
Arabidopsis thaliana | AT1G24320 | alpha-glucosidase 2 |
Brugia malayi | Bm1_40265 | Mannosyl oligosaccharide glucosidase family protein |
Candida albicans | CaO19.4719 | similar to C terminus of S. cerevisiae CWH41 (YGL027C) glucosidase I |
Candida albicans | CaO19.4421 | similar to N terminus of S. cerevisiae CWH41 (YGL027C) glucosidase I |
Candida albicans | CaO19.11899 | similar to N terminus of S. cerevisiae CWH41 (YGL027C) glucosidase I |
Caenorhabditis elegans | CELE_F13H10.4 | Protein F13H10.4, isoform B |
Dictyostelium discoideum | DDB_G0280145 | glycoside hydrolase family 63 protein |
Drosophila melanogaster | Dmel_CG1597 | CG1597 gene product from transcript CG1597-RB |
Echinococcus granulosus | EgrG_000315000 | mannosyl oligosaccharide glucosidase |
Echinococcus multilocularis | EmuJ_000315000 | |
Homo sapiens | ENSG00000115275 | mannosyl-oligosaccharide glucosidase |
Leishmania braziliensis | LbrM.28.2400 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_282350.1 | Mannosyl oligosaccharide glucosidase, putative |
Leishmania infantum | LinJ.28.2350 | hypothetical protein, conserved |
Leishmania major | LmjF.28.2200 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.28.2200 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_03690 | mannosyl oligosaccharide glucosidase |
Mus musculus | ENSMUSG00000030036 | mannosyl-oligosaccharide glucosidase |
Oryza sativa | 4327748 | Os01g0921200 |
Saccharomyces cerevisiae | YGL027C | Cwh41p |
Schistosoma japonicum | Sjp_0310110 | ko:K01228 mannosyl-oligosaccharide glucosidase [EC3.2.1.106], putative |
Schistosoma japonicum | Sjp_0314810 | ko:K01228 mannosyl-oligosaccharide glucosidase [EC3.2.1.106], putative |
Schistosoma japonicum | Sjp_0060890 | Mannosyl-oligosaccharide glucosidase, putative |
Schistosoma japonicum | Sjp_0060870 | Mannosyl-oligosaccharide glucosidase, putative |
Schistosoma mansoni | Smp_024580.2 | mannosyl-oligosaccharide glucosidase |
Schistosoma mansoni | Smp_024580.1 | mannosyl-oligosaccharide glucosidase |
Schmidtea mediterranea | mk4.005350.04 | |
Schmidtea mediterranea | mk4.010495.00 | |
Trypanosoma cruzi | TcCLB.511805.10 | mannosyl-oligosaccharide glucosidase, putative |
Trypanosoma cruzi | TcCLB.509201.10 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_F13H10.4 | Caenorhabditis elegans | slow growth | wormbase |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.