Detailed view for LmxM.36.6290

Basic information

TDR Targets ID: 443527
Leishmania mexicana, glucose transporter, lmgt2
Source Database / ID: 

pI: 6.3282 | Length (AA): 567 | MW (Da): 61175 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 12

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00083   Sugar (and other) transporter

Gene Ontology

Mouse over links to read term descriptions.
GO:0022857   transmembrane transporter activity  
GO:0016021   integral to membrane  
GO:0016020   membrane  
GO:0005215   transporter activity  
GO:0055085   transmembrane transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
114 244 4ybq (A) 8 157 17.00 0 0.05 0.378941 -0.09
147 540 4tph (A) 40 490 17.00 0 0.6 0.679785 0.72
167 536 5c65 (A) 73 451 25.00 0 0.88 0.802357 0.38
335 426 4rfs (S) 90 184 33.00 0.71 0.04 0.256058 1.4

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129633)

Species Accession Gene Product
Dictyostelium discoideum DDB_G0286151   hypothetical protein
Dictyostelium discoideum DDB_G0281155   sugar transporter family protein
Dictyostelium discoideum DDB_G0277773   solute carrier family 2 member protein
Dictyostelium discoideum DDB_G0292814   calmodulin-binding protein
Leishmania braziliensis LbrM.35.6480   lmgt2, putative
Leishmania braziliensis LbrM.35.6490   glucose transporter, lmgt2
Leishmania braziliensis LbrM.33.0290   glucose transporter/membrane transporter D2, putative
Leishmania donovani LdBPK_366560.1   glucose transporter 1
Leishmania donovani LdBPK_366540.1   glucose transporter 3, putative
Leishmania donovani LdBPK_330310.1   glucose transporter/membrane transporter D2, putative
Leishmania infantum LinJ.33.0310   glucose transporter/membrane transporter D2, putative
Leishmania infantum LinJ.36.6540   glucose transporter, lmgt3
Leishmania infantum LinJ.36.6560   glucose transporter, lmgt1
Leishmania infantum LinJ.36.6550   glucose transporter, lmgt2
Leishmania major LmjF.33.0290   glucose transporter/membrane transporter D2, putative
Leishmania major LmjF.36.6300   glucose transporter, lmgt1
Leishmania major LmjF.36.6280   glucose transporter, lmgt3
Leishmania major LmjF.36.6290   glucose transporter, lmgt2
Leishmania mexicana LmxM.32.0290   glucose transporter/membrane transporter D2, putative
Leishmania mexicana LmxM.36.6300   glucose transporter, lmgt1
Leishmania mexicana LmxM.36.6280   glucose transporter, lmgt3
Leishmania mexicana LmxM.36.6290   glucose transporter, lmgt2
Trypanosoma brucei gambiense Tbg972.10.10290   hexose transporter,glucose transporter 1B, putative
Trypanosoma brucei gambiense Tbg972.4.2260   glucose transporter, putative
Trypanosoma brucei gambiense Tbg972.10.10310   glucose transporter
Trypanosoma brucei gambiense Tbg972.10.10300   glucose transporter,glucose transporter 2A, putative
Trypanosoma brucei gambiense Tbg972.10.10280   hexose transporter,glucose transporter 1B
Trypanosoma brucei Tb11.v5.0307   THT1 - hexose transporter, putative
Trypanosoma brucei Tb927.10.8500   glucose transporter, putative
Trypanosoma brucei Tb927.10.8490   glucose transporter, putative
Trypanosoma brucei Tb927.10.8510   glucose transporter, putative
Trypanosoma brucei Tb927.10.8460   glucose transporter, putative
Trypanosoma brucei Tb927.10.8480   glucose transporter, putative
Trypanosoma brucei Tb927.10.8520   glucose transporter, putative
Trypanosoma brucei Tb927.10.8530   glucose transporter 2A
Trypanosoma brucei Tb11.v5.0310   THT1 - hexose transporter, putative
Trypanosoma brucei Tb11.v5.0330   THT1 - hexose transporter, putative
Trypanosoma brucei Tb927.4.2290   glucose transporter, putative
Trypanosoma brucei Tb927.10.8450   glucose transporter 1E
Trypanosoma brucei Tb927.10.8470   glucose transporter, putative
Trypanosoma congolense TcIL3000_4_2100   glucose transporter, putative
Trypanosoma congolense TcIL3000_10_7320   glucose transporter 2A, putative
Trypanosoma congolense TcIL3000_10_7310   glucose transporter, putative
Trypanosoma cruzi TcCLB.511041.40   hexose transporter, putative
Trypanosoma cruzi TcCLB.506355.10   hexose transporter
Trypanosoma cruzi TcCLB.508551.39   hexose transporter, putative
Trypanosoma cruzi TcCLB.506355.5   hexose transporter, putative
Trypanosoma cruzi TcCLB.508551.30   hexose transporter, putative
Trichomonas vaginalis TVAG_247420   glucose transporter, putative
Trichomonas vaginalis TVAG_039990   sugar transporter, putative
Trichomonas vaginalis TVAG_040000   glucose transporter, putative
Trichomonas vaginalis TVAG_039960   sugar transporter, putative
Trichomonas vaginalis TVAG_039970   conserved hypothetical protein
Trichomonas vaginalis TVAG_037050   sugar transporter, putative
Trichomonas vaginalis TVAG_495680   conserved hypothetical protein

Essentiality

LmxM.36.6290 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.2290 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.2290 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.4.2290 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.2290 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.8530 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.8530 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.8530 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.8530 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.8440 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.8440 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.8440 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.8440 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

774 chemical compounds are associated with this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Solute carrier family 2, facilitated glucose transporter member 1 492 aa 24.0% 404 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • ChEMBL
  • ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro
  • ChEMBL
  • ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier LmxM.36.6290 (Leishmania mexicana), glucose transporter, lmgt2
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