Detailed view for LmxM.33.0480

Basic information

TDR Targets ID: 444051
Leishmania mexicana, calcium channel protein, putative,ion transporter, putative
Source Database / ID: 

pI: 8.6227 | Length (AA): 2547 | MW (Da): 290285 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 21

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00520   Ion transport protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005216   ion channel activity  
GO:0055085   transmembrane transport  
GO:0006811   ion transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
12 75 5a6r (A) 31 94 11.00 0.0000069 0.09 0.129728 -0.16
14 106 1nn7 (A) 43 137 9.00 0.00024 0.03 -0.0398865 0.59
354 420 5hk6 (B) 180 259 31.00 0.0017 0.09 0.210005 0.98
1615 1863 5hvx (A) 38 238 30.00 0.000000032 0.18 -0.0415379 1.6
1895 2140 5ek0 (A) 1500 1722 28.00 0 0.48 0.195284 1.02
2156 2301 4dck (A) 1789 1920 25.00 0.0054 0.88 0.207022 0.11

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126819)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG34405   Na channel protein 60E
Drosophila melanogaster Dmel_CG9907   paralytic
Echinococcus granulosus EgrG_000080200   sodium channel protein
Echinococcus granulosus EgrG_000080100   voltage gated sodium channel Nav1 alpha subunit
Echinococcus multilocularis EmuJ_000080200   sodium channel protein
Homo sapiens ENSG00000183873   sodium channel, voltage-gated, type V, alpha subunit
Homo sapiens ENSG00000168356   sodium channel, voltage-gated, type XI, alpha subunit
Homo sapiens ENSG00000007314   sodium channel, voltage-gated, type IV, alpha subunit
Homo sapiens ENSG00000144285   sodium channel, voltage-gated, type I, alpha subunit
Homo sapiens ENSG00000196876   sodium channel, voltage gated, type VIII, alpha subunit
Homo sapiens ENSG00000136531   sodium channel, voltage-gated, type II, alpha subunit
Homo sapiens ENSG00000153253   sodium channel, voltage-gated, type III, alpha subunit
Homo sapiens ENSG00000136546   sodium channel, voltage-gated, type VII, alpha subunit
Homo sapiens ENSG00000169432   sodium channel, voltage-gated, type IX, alpha subunit
Homo sapiens ENSG00000185313   sodium channel, voltage-gated, type X, alpha subunit
Leishmania braziliensis LbrM.20.0460   calcium channel protein, putative,ion transporter, putative
Leishmania donovani LdBPK_340500.1   calcium channel protein, putative
Leishmania infantum LinJ.34.0500   calcium channel protein, putative,ion transporter, putative
Leishmania major LmjF.34.0480   calcium channel protein, putative,ion transporter, putative
Leishmania mexicana LmxM.33.0480   calcium channel protein, putative,ion transporter, putative
Mus musculus ENSMUSG00000075318   sodium channel, voltage-gated, type II, alpha 1
Mus musculus ENSMUSG00000034533   sodium channel, voltage-gated, type X, alpha
Mus musculus ENSMUSG00000032511   sodium channel, voltage-gated, type V, alpha
Mus musculus ENSMUSG00000023033   sodium channel, voltage-gated, type VIII, alpha
Mus musculus ENSMUSG00000057182   sodium channel, voltage-gated, type III, alpha
Mus musculus ENSMUSG00000001027   sodium channel, voltage-gated, type IV, alpha
Mus musculus ENSMUSG00000064329   sodium channel, voltage-gated, type I, alpha
Mus musculus ENSMUSG00000034810   sodium channel, voltage-gated, type VII, alpha
Mus musculus ENSMUSG00000034115   sodium channel, voltage-gated, type XI, alpha
Mus musculus ENSMUSG00000075316   sodium channel, voltage-gated, type IX, alpha
Schmidtea mediterranea mk4.002058.04  
Schmidtea mediterranea mk4.001127.00   Sodium channel protein para
Schmidtea mediterranea mk4.002439.02   Sodium channel protein type 7 subunit alpha
Schmidtea mediterranea mk4.026661.01   Sodium channel protein para
Schmidtea mediterranea mk4.000185.19  
Schmidtea mediterranea mk4.002439.01   Sodium channel protein para
Schmidtea mediterranea mk4.002439.03   Sodium channel protein para
Schmidtea mediterranea mk4.000987.06  
Schmidtea mediterranea mk4.002058.02  
Schmidtea mediterranea mk4.005308.04   Sodium channel protein type 7 subunit alpha
Schmidtea mediterranea mk4.000296.09   Sodium channel protein type 7 subunit alpha
Schmidtea mediterranea mk4.002439.00   Sodium channel protein para
Schmidtea mediterranea mk4.026661.00  
Schmidtea mediterranea mk4.001585.02   Sodium channel protein para
Schmidtea mediterranea mk4.005308.03   Sodium channel protein type 7 subunit alpha
Schmidtea mediterranea mk4.015645.00   Sodium channel protein para
Schmidtea mediterranea mk4.002058.03  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens sodium channel, voltage-gated, type III, alpha subunit Compounds References
Homo sapiens sodium channel, voltage gated, type VIII, alpha subunit Compounds References
Rattus norvegicus Sodium channel protein type VIII alpha subunit Compounds References
Homo sapiens sodium channel, voltage-gated, type II, alpha subunit Compounds References
Rattus norvegicus Sodium channel protein type IV alpha subunit Compounds References
Rattus norvegicus Sodium channel protein type V alpha subunit Compounds References
Mus musculus sodium channel, voltage-gated, type IV, alpha Compounds References
Canis lupus familiaris Voltage-gated sodium channel Nav1.5 cardiac isoform Compounds References
Homo sapiens sodium channel, voltage-gated, type IV, alpha subunit Compounds References
Homo sapiens sodium channel, voltage-gated, type IX, alpha subunit Compounds References
Mus musculus sodium channel, voltage-gated, type IX, alpha Compounds References
Homo sapiens sodium channel, voltage-gated, type VII, alpha subunit Compounds References
Mus musculus sodium channel, voltage-gated, type VIII, alpha Compounds References
Homo sapiens sodium channel, voltage-gated, type X, alpha subunit Compounds References
Rattus norvegicus Sodium channel protein type II alpha subunit Compounds References
Homo sapiens sodium channel, voltage-gated, type I, alpha subunit Compounds References
Rattus norvegicus Sodium channel protein type I alpha subunit Compounds References
Rattus norvegicus Sodium channel protein type III alpha subunit Compounds References
Homo sapiens sodium channel, voltage-gated, type V, alpha subunit Compounds References
Rattus norvegicus Sodium channel protein type X alpha subunit Compounds References
Mus musculus sodium channel, voltage-gated, type X, alpha Compounds References
Homo sapiens sodium channel, voltage-gated, type XI, alpha subunit Compounds References
Rattus norvegicus Sodium channel protein type IX alpha subunit Compounds References
Mus musculus sodium channel, voltage-gated, type I, alpha Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmxM.33.0480 (Leishmania mexicana), calcium channel protein, putative,ion transporter, putative
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