Detailed view for LmxM.24.2030

Basic information

TDR Targets ID: 444223
Leishmania mexicana, 3-oxoacyl-(acyl-carrier protein) reductase, putative
Source Database / ID: 

pI: 8.7339 | Length (AA): 259 | MW (Da): 27082 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13561   Enoyl-(Acyl carrier protein) reductase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016491   oxidoreductase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 259 3ppi (A) 2 259 42.00 0 1 1.51226 -0.5
7 64 3l07 (A) 154 211 22.00 0 0.95 0.582738 -1.03
8 38 4hp8 (A) 6 36 58.00 0 1 0.725491 0.15
9 39 1o5i (A) 5 35 45.00 0 0.83 0.582491 0.11
9 259 4xgn (A) 3 252 56.00 0 1 1.66921 -0.91

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129031)

Species Accession Gene Product
Arabidopsis thaliana AT3G26770   NAD(P)-binding Rossmann-fold superfamily protein
Brugia malayi Bm1_06360   3-hydroxyacyl-CoA dehydrogenase type II
Caenorhabditis elegans CELE_F01G4.2   Protein ARD-1
Cryptosporidium hominis Chro.30048   scully CG7113-PA
Cryptosporidium parvum cgd3_330   scully CG7113-PA, putative
Dictyostelium discoideum DDB_G0272128   hypothetical protein
Drosophila melanogaster Dmel_CG7113   scully
Echinococcus granulosus EgrG_000790800   3 hydroxyacyl coenzyme A dehydrogenase type 2
Echinococcus multilocularis EmuJ_000790800   3 hydroxyacyl coenzyme A dehydrogenase type 2
Homo sapiens ENSG00000072506   hydroxysteroid (17-beta) dehydrogenase 10
Leishmania braziliensis LbrM.24.2110   3-oxoacyl-(acyl-carrier protein) reductase, putative
Leishmania donovani LdBPK_242110.1   3-oxoacyl-(acyl-carrier protein) reductase, putative
Leishmania infantum LinJ.24.2110   3-oxoacyl-(acyl-carrier protein) reductase, putative
Leishmania major LmjF.24.2030   3-oxoacyl-(acyl-carrier protein) reductase, putative
Leishmania mexicana LmxM.24.2030   3-oxoacyl-(acyl-carrier protein) reductase, putative
Loa Loa (eye worm) LOAG_02590   3-hydroxyacyl-CoA dehydrogenase type II
Mus musculus ENSMUSG00000025260   hydroxysteroid (17-beta) dehydrogenase 10
Mycobacterium tuberculosis Rv1144   Probable short-chain type dehydrogenase/reductase
Mycobacterium ulcerans MUL_3412   short-chain type dehydrogenase/reductase
Mycobacterium ulcerans MUL_0987   short-chain type dehydrogenase/reductase
Oryza sativa 4344207   Os07g0664600
Schistosoma japonicum Sjp_0304650   ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative
Schistosoma mansoni Smp_151030   3-hydroxyacyl-CoA dehydrogenase
Schmidtea mediterranea mk4.017150.00   3 hydroxyacyl CoA dehydrogenase type-2
Schmidtea mediterranea mk4.044537.01   3-hydroxyacyl-CoA dehydrogenase
Schmidtea mediterranea mk4.027281.02   3-hydroxyacyl-CoA dehydrogenase type-2

Essentiality

LmxM.24.2030 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu1165 Mycobacterium tuberculosis non-essential nmpdr
CELE_F01G4.2 Caenorhabditis elegans larval arrest wormbase
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bacillus subtilis (strain 168) Enoyl-[acyl-carrier-protein] reductase [NADH] 258 aa 23.1% 273 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmxM.24.2030 (Leishmania mexicana), 3-oxoacyl-(acyl-carrier protein) reductase, putative
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