Detailed view for LmxM.15.1530

Basic information

TDR Targets ID: 445942
Leishmania mexicana, presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative
Source Database / ID: 

pI: 7.3416 | Length (AA): 352 | MW (Da): 38885 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 7

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01080   Presenilin

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0004190   aspartic-type endopeptidase activity  
GO:0016485   protein processing  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
20 180 3vvp (A) 267 438 16.00 0 0.04 0.528686 -0.14
213 351 2kr6 (A) 328 467 31.00 0 0.46 0.499686 1.89

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128959)

Species Accession Gene Product
Arabidopsis thaliana AT2G29900   Presenilin-2
Arabidopsis thaliana AT1G08700   Presenilin-1
Brugia malayi Bm1_20450   Presenilin family protein
Caenorhabditis elegans CELE_F35H12.3   Protein SEL-12
Dictyostelium discoideum DDB_G0291352   peptidase A22 family protein
Dictyostelium discoideum DDB_G0292310   peptidase A22 family protein
Drosophila melanogaster Dmel_CG18803   Presenilin
Echinococcus granulosus EgrG_000780700   presenilin
Entamoeba histolytica EHI_188280   presenilin 1 peptidase, putative
Echinococcus multilocularis EmuJ_000780700   presenilin
Homo sapiens ENSG00000080815   presenilin 1
Homo sapiens ENSG00000143801   presenilin 2
Leishmania braziliensis LbrM.15.1530   presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative
Leishmania donovani LdBPK_151600.1   presenilin-like aspartic peptidase, putative
Leishmania infantum LinJ.15.1600   presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative
Leishmania major LmjF.15.1530   presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative
Leishmania mexicana LmxM.15.1530   presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative
Mus musculus ENSMUSG00000010609   presenilin 2
Mus musculus ENSMUSG00000019969   presenilin 1
Oryza sativa 9272037   Os03g0603700
Oryza sativa 4324260   Os01g0276400
Schistosoma japonicum Sjp_0213160   ko:K04505 presenilin-1, putative
Schistosoma mansoni Smp_153960   subfamily A22A unassigned peptidase (A22 family)
Schmidtea mediterranea mk4.000085.14   Presenilin spe-4
Schmidtea mediterranea mk4.000085.15  
Trypanosoma brucei gambiense Tbg972.9.2640   presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative
Trypanosoma brucei Tb927.9.4940   presenilin-like aspartic peptidase, putative
Trypanosoma congolense TcIL3000_9_1620   presenilin-like aspartic peptidase, putative
Trypanosoma cruzi TcCLB.503543.10   presenilin-like aspartic peptidase, putative
Trypanosoma cruzi TcCLB.508277.50   presenilin-like aspartic peptidase, putative
Trichomonas vaginalis TVAG_026700   Clan AD, family A22, presenilin-like aspartic peptidase
Trichomonas vaginalis TVAG_428310   Clan AD, family A22, presenilin-like aspartic peptidase
Trichomonas vaginalis TVAG_412920   Clan AD, family A22, presenilin-like aspartic peptidase

Essentiality

LmxM.15.1530 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.160.3510 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.160.3510 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.160.3510 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.160.3510 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens presenilin 2 Compounds References
Homo sapiens presenilin 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmxM.15.1530 (Leishmania mexicana), presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative
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