Detailed view for LmxM.06.0610

Basic information

TDR Targets ID: 448380
Leishmania mexicana, carbonic anhydrase family protein, putative
Source Database / ID: 

pI: 6.9826 | Length (AA): 306 | MW (Da): 34603 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00484   Carbonic anhydrase

Gene Ontology

Mouse over links to read term descriptions.
GO:0004089   carbonate dehydratase activity  
GO:0008270   zinc ion binding  
GO:0015976   carbon utilization  

Metabolic Pathways

Nitrogen metabolism (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
55 304 1ddz (A) 97 325 38.00 0 1 1.17909 0.08
69 300 5cxk (A) 1 213 45.00 0 1 1.22827 -0.2
71 303 3qy1 (A) 3 216 45.00 0 1 1.28454 -0.73

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127503)

Species Accession Gene Product
Arabidopsis thaliana AT1G58180   beta carbonic anhydrase 6
Arabidopsis thaliana AT3G01500   carbonic anhydrase 1
Arabidopsis thaliana AT5G14740   carbonic anhydrase 2
Candida albicans CaO19.9289   Involved in protection against oxidative damage
Candida albicans CaO19.1721   Involved in protection against oxidative damage
Caenorhabditis elegans CELE_T13C5.5   Protein BCA-1
Dictyostelium discoideum DDB_G0269106   carbonic anhydrase
Dictyostelium discoideum DDB_G0274643   hypothetical protein
Drosophila melanogaster Dmel_CG11967   Carbonic anhydrase beta
Escherichia coli b0126   carbonic anhydrase
Escherichia coli b0339   carbonic anhydrase
Entamoeba histolytica EHI_073380   carbonic anhydrase, putative
Leishmania braziliensis LbrM.06.0620   carbonic anhydrase family protein, putative
Leishmania donovani LdBPK_060630.1   carbonic anhydrase family protein, putative
Leishmania infantum LinJ.06.0630   carbonic anhydrase family protein, putative
Leishmania major LmjF.06.0610   carbonic anhydrase family protein, putative
Leishmania mexicana LmxM.06.0610   carbonic anhydrase family protein, putative
Mycobacterium leprae ML1919c   CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE)
Mycobacterium tuberculosis Rv3588c   Beta-carbonic anhydrase CanB
Mycobacterium ulcerans MUL_4164   carbonic anhydrase
Oryza sativa 9266472   Os01g0640132
Oryza sativa 4326583   Os01g0639900
Saccharomyces cerevisiae YNL036W   carbonate dehydratase NCE103
Schistosoma japonicum Sjp_0056790   ko:K01672 carbonic anhydrase [EC4.2.1.1], putative
Schistosoma mansoni Smp_004070   carbonic anhydrase
Schmidtea mediterranea mk4.075550.00  

Essentiality

LmxM.06.0610 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b0126 Escherichia coli essential goodall
b0339 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Candida glabrata CBS 138 Carbonic anhydrase Compounds References
Saccharomyces cerevisiae carbonate dehydratase NCE103 Compounds References
Anopheles gambiae AGAP002992-PA Compounds References
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) Carbonic anhydrase 1 Compounds References
Flaveria bidentis Carbonic anhydrase Compounds References
Cryptococcus neoformans var. grubii Carbonic anhydrase 2 Compounds References
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) Carbonic anhydrase Compounds References
Candida albicans Involved in protection against oxidative damage Compounds References
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmxM.06.0610 (Leishmania mexicana), carbonic anhydrase family protein, putative
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