Detailed view for LmxM.14.0020

Basic information

TDR Targets ID: 449612
Leishmania mexicana, phosphatidylinositol 3-kinase, putative
Source Database / ID: 

pI: 7.6346 | Length (AA): 942 | MW (Da): 107775 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00454   Phosphatidylinositol 3- and 4-kinase
PF00613   Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PF00792   Phosphoinositide 3-kinase C2
PF00794   PI3-kinase family, ras-binding domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016303   1-phosphatidylinositol-3-kinase activity  
GO:0016301   kinase activity  
GO:0005488   binding  
GO:0048015   phosphoinositide-mediated signaling  
GO:0046854   phosphoinositide phosphorylation  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 940 1e7u (A) 171 1091 32.00 0 1 1.20652 0.18
3 934 5ae8 (A) 135 1032 33.00 0 1 1.23508 0.02
71 926 5dxu (A) 199 1023 38.00 0 1 1.083 0.78
417 931 4uwh (A) 286 872 31.00 0 1 0.881409 -0.57

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127444)

Species Accession Gene Product
Brugia malayi Bm1_55680   Phosphatidylinositol 3- and 4-kinase family protein
Caenorhabditis elegans CELE_B0334.8   Protein AGE-1
Dictyostelium discoideum DDB_G0268548   phosphatidylinositol 3-kinase
Dictyostelium discoideum DDB_G0283081   phosphatidylinositol-4,5-diphosphate 3-kinase
Dictyostelium discoideum DDB_G0278727   phosphatidylinositol-4,5-diphosphate 3-kinase
Dictyostelium discoideum DDB_G0275011   phosphatidylinositol-4,5-diphosphate 3-kinase
Drosophila melanogaster Dmel_CG4141   CG4141 gene product from transcript CG4141-RB
Echinococcus granulosus EgrG_000526100   phosphatidylinositol 45 bisphosphate 3 kinase
Entamoeba histolytica EHI_006130   phosphatidylinositol 3-kinase, putative
Entamoeba histolytica EHI_073560   phosphatidylinositol 3-kinase 1, putative
Entamoeba histolytica EHI_188970   hypothetical protein
Entamoeba histolytica EHI_095130   phosphatidylinositol 3-kinase, putative
Echinococcus multilocularis EmuJ_000526100   phosphatidylinositol 4,5 bisphosphate 3 kinase
Giardia lamblia GL50803_14855   Phosphoinositide-3-kinase, catalytic, alpha polypeptide
Homo sapiens ENSG00000051382   phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Homo sapiens ENSG00000171608   phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Homo sapiens ENSG00000105851   phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Homo sapiens 5290   phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Leishmania donovani LdBPK_140020.1   phosphatidylinositol 3-kinase 2, putative
Leishmania infantum LinJ.14.0020   phosphatidylinositol 3-kinase 2, putative
Leishmania mexicana LmxM.14.0020   phosphatidylinositol 3-kinase, putative
Loa Loa (eye worm) LOAG_04612   phosphatidylinositol 3
Loa Loa (eye worm) LOAG_00517   hypothetical protein
Mus musculus ENSMUSG00000027665   phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
Mus musculus 74769   phosphatidylinositol 3-kinase, catalytic, beta polypeptide
Mus musculus ENSMUSG00000020573   phosphoinositide-3-kinase, catalytic, gamma polypeptide
Mus musculus ENSMUSG00000039936   phosphatidylinositol 3-kinase catalytic delta polypeptide
Schistosoma japonicum Sjp_0024750   ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative
Schistosoma mansoni Smp_164960   phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K
Schmidtea mediterranea mk4.006914.00   Pi3k-like protein
Schmidtea mediterranea mk4.003675.00   Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma
Trypanosoma cruzi TcCLB.508859.90   phosphatidylinositol 3-kinase 2, putative
Trypanosoma cruzi TcCLB.510167.10   phosphatidylinositol 3-kinase 2, putative
Trichomonas vaginalis TVAG_284350   phosphatidylinositol kinase, putative
Trichomonas vaginalis TVAG_101460   phosphatidylinositol 3-kinase catalytic subunit gamma, putative
Trichomonas vaginalis TVAG_344900   phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative
Trichomonas vaginalis TVAG_083340   phopsphatidylinositol 3-kinase, drosophila, putative
Trichomonas vaginalis TVAG_393100   phosphatidylinositol 3-kinase class, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus phosphatidylinositol 3-kinase, catalytic, alpha polypeptide Compounds References
Mus musculus phosphatidylinositol 3-kinase catalytic delta polypeptide Compounds References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Compounds References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta Compounds References
Rattus norvegicus Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Compounds References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma Compounds References
Bos taurus PI3-kinase p110-alpha subunit Compounds References
Mus musculus phosphoinositide-3-kinase, catalytic, gamma polypeptide Compounds References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmxM.14.0020 (Leishmania mexicana), phosphatidylinositol 3-kinase, putative
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