Detailed view for LmxM.06.0650

Basic information

TDR Targets ID: 449815
Leishmania mexicana, lanosterol synthase, putative
Source Database / ID: 

pI: 7.4096 | Length (AA): 1002 | MW (Da): 113624 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13243   Squalene-hopene cyclase C-terminal domain
PF13249   Squalene-hopene cyclase N-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016866   intramolecular transferase activity  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
228 1001 1w6k (A) 11 729 39.00 0 1 1.19656 -0.65
286 991 2sqc (A) 10 624 20.00 0 1 0.787291 -0.15

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127966)

Species Accession Gene Product
Arabidopsis thaliana AT4G15340   pentacyclic triterpene synthase 1
Arabidopsis thaliana AT1G78970   lupeol synthase 1
Arabidopsis thaliana AT5G36150   tirucalladienol synthase
Arabidopsis thaliana AT3G45130   lanosterol synthase 1
Arabidopsis thaliana AT5G42600   marneral synthase
Arabidopsis thaliana AT5G48010   thalianol synthase 1
Arabidopsis thaliana AT1G78950   beta-amyrin synthase
Arabidopsis thaliana AT1G78960   lupeol synthase 2
Arabidopsis thaliana AT1G78955   camelliol C synthase 1
Arabidopsis thaliana AT1G66960   Terpenoid cyclases family protein
Arabidopsis thaliana AT2G07050   cycloartenol synthase
Arabidopsis thaliana AT3G29255   putative pentacyclic triterpene synthase 7
Arabidopsis thaliana AT4G15370   baruol synthase 1
Arabidopsis thaliana AT1G78500   pentacyclic triterpene synthase 6
Candida albicans CaO19.9143   2,3-oxidosqualene-lanosterol cyclase
Candida albicans CaO19.1570   2,3-oxidosqualene-lanosterol cyclase
Dictyostelium discoideum DDB_G0269226   cycloartenol synthase
Homo sapiens ENSG00000160285   lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
Leishmania braziliensis LbrM.06.0650   lanosterol synthase, putative
Leishmania donovani LdBPK_060670.1   lanosterol synthase, putative
Leishmania infantum LinJ.06.0670   lanosterol synthase, putative
Leishmania major LmjF.06.0650   lanosterol synthase, putative
Leishmania mexicana LmxM.06.0650   lanosterol synthase, putative
Mus musculus 16987   lanosterol synthase
Oryza sativa 4328259   Os02g0140200
Oryza sativa 4350295   Os11g0286800
Oryza sativa 9268610   Os11g0189600
Oryza sativa 4328261   Os02g0140400
Oryza sativa 4328256   Os02g0139700
Oryza sativa 4328254   Os02g0139500
Oryza sativa 4344966   Os08g0223900
Oryza sativa 4350288   Os11g0285000
Oryza sativa 4350734   Os11g0562100
Saccharomyces cerevisiae YHR072W   lanosterol synthase ERG7
Trypanosoma brucei gambiense Tbg972.7.6010   lanosterol synthase
Trypanosoma brucei Tb927.7.5230   lanosterol synthase
Trypanosoma congolense TcIL3000_0_16660   lanosterol synthase
Trypanosoma cruzi TcCLB.506825.170   lanosterol synthase, putative
Trypanosoma cruzi TcCLB.508175.70   lanosterol synthase, putative

Essentiality

LmxM.06.0650 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.5230 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.5230 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.5230 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.7.5230 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
YHR072W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Trypanosoma cruzi lanosterol synthase, putative Compounds References
Arabidopsis thaliana cycloartenol synthase Compounds References
Trypanosoma cruzi lanosterol synthase, putative Compounds References
Rattus norvegicus Lanosterol synthase Compounds References
Pneumocystis carinii Lanosterol synthase Compounds References
Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC27009 / DSM 446 / 104-1A) (Bacillu Squalene-hopene cyclase Compounds References
Saccharomyces cerevisiae lanosterol synthase ERG7 Compounds References
Candida albicans 2,3-oxidosqualene-lanosterol cyclase Compounds References
Homo sapiens lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmxM.06.0650 (Leishmania mexicana), lanosterol synthase, putative
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