Detailed view for LmxM.26.2240

Basic information

TDR Targets ID: 450398
Leishmania mexicana, kynureninase, putative
Source Database / ID: 

pI: 6.3148 | Length (AA): 468 | MW (Da): 50725 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00266   Aminotransferase class-V

Gene Ontology

Mouse over links to read term descriptions.
GO:0005737   cytoplasm  
GO:0030429   kynureninase activity  
GO:0030170   pyridoxal phosphate binding  
GO:0003824   catalytic activity  
GO:0009435   NAD biosynthetic process  
GO:0006569   tryptophan catabolic process  

Metabolic Pathways

Tryptophan metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 468 3e9k (A) 8 458 35.00 0 1 1.36449 -0.51
103 292 5usr (E) 108 300 24.00 0.0004 1 0.720283 -0.71
186 279 2e7j (A) 126 222 32.00 0.86 1 0.570155 -0.26

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129469)

Species Accession Gene Product
Brugia malayi Bm1_03765   hypothetical protein
Brugia malayi Bm1_18725   FLYWCH zinc finger domain containing protein
Brugia malayi Bm1_17865   kynureninase family protein
Candida albicans CaO19.394   possible L-kynurenine hydrolase
Candida albicans CaO19.8024   possible L-kynurenine hydrolase
Caenorhabditis elegans CELE_C15H9.7   Protein FLU-2
Dictyostelium discoideum DDB_G0284203   L-kynurenine hydrolase
Echinococcus granulosus EgrG_000735700   Pyridoxal phosphate dependent transferase major region subdomain 1
Echinococcus multilocularis EmuJ_000735700   Pyridoxal phosphate dependent transferase, major region, subdomain 1
Homo sapiens ENSG00000115919   kynureninase
Leishmania braziliensis LbrM.26.2160   kynureninase, putative
Leishmania donovani LdBPK_262250.1   kynureninase, putative
Leishmania infantum LinJ.26.2250   kynureninase, putative
Leishmania major LmjF.26.2240   kynureninase, putative
Leishmania mexicana LmxM.26.2240   kynureninase, putative
Loa Loa (eye worm) LOAG_11570   kynureninase
Loa Loa (eye worm) LOAG_10046   hypothetical protein
Mus musculus 102642818   kynureninase 1-like
Mus musculus ENSMUSG00000026866   kynureninase (L-kynurenine hydrolase)
Saccharomyces cerevisiae YLR231C   kynureninase
Schistosoma japonicum Sjp_0007600   ko:K01556 kynureninase [EC3.7.1.3], putative
Schistosoma mansoni Smp_023470   3-hydroxy-kinureninase
Schmidtea mediterranea mk4.000938.00   Kynureninase
Schmidtea mediterranea mk4.001746.00   Kynureninase
Trypanosoma brucei gambiense Tbg972.9.710   kynureninase, putative
Trypanosoma brucei Tb427tmp.160.0810   kynureninase, putative
Trypanosoma brucei Tb927.9.2010   kynureninase, putative
Trypanosoma congolense TcIL3000_9_490   kynureninase, putative
Trypanosoma cruzi TcCLB.508119.110   kynureninase, putative
Trypanosoma cruzi TcCLB.503881.10   kynureninase, putative

Essentiality

LmxM.26.2240 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.160.0810 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.160.0810 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.160.0810 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.160.0810 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Kynureninase Compounds References
Homo sapiens kynureninase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmxM.26.2240 (Leishmania mexicana), kynureninase, putative
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