Detailed view for TcCLB.510903.60

Basic information

TDR Targets ID: 45062
Trypanosoma cruzi, prenyltransferase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 9.1399 | Length (AA): 490 | MW (Da): 55232 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 8

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01040   UbiA prenyltransferase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016765   transferase activity, transferring alkyl or aryl (other than methyl) groups  
GO:0016021   integral to membrane  
GO:0004659   prenyltransferase activity  
GO:0006744   ubiquinone biosynthetic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
106 368 4od4 (A) 9 277 21.00 0.0000077 0.41 0.703235 0.21
371 425 4otn (A) 1560 1615 35.00 0.11 0.06 0.392045 0.44

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127332)

Species Accession Gene Product
Arabidopsis thaliana AT4G23660   4-hydroxybenzoate polyprenyltransferase
Babesia bovis BBOV_III000400   prenyltransferase, UbiA family protein
Brugia malayi Bm1_41475   4-hydroxybenzoate polyprenyl transferase family protein
Candida albicans CaO19.7643   para hydroxybenzoate: polyprenyl transferase
Caenorhabditis elegans CELE_F57B9.4   Protein COQ-2, isoform D
Cryptosporidium hominis Chro.30285   UbiA prenyltransferase family member (3I27)
Cryptosporidium parvum cgd3_2460   UbiA prenyltransferase family member (3I27) , putative
Chlamydia trachomatis CT_219   4-hydroxybenzoate octaphenyltransferase
Dictyostelium discoideum DDB_G0281241   4-hydroxybenzoate nonaprenyltransferase
Drosophila melanogaster Dmel_CG9613   Coenzyme Q biosynthesis protein 2
Escherichia coli b4040   p-hydroxybenzoate octaprenyltransferase
Echinococcus multilocularis EmuJ_001183400   Para hydroxybenzoate polyprenyltransferase
Homo sapiens ENSG00000173085   coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
Leishmania braziliensis LbrM.28.1420   prenyltransferase, putative
Leishmania donovani LdBPK_281430.1   prenyltransferase, putative
Leishmania infantum LinJ.28.1430   prenyltransferase, putative
Leishmania major LmjF.28.1320   prenyltransferase, putative
Leishmania mexicana LmxM.28.1320   prenyltransferase, putative
Loa Loa (eye worm) LOAG_05795   4-hydroxybenzoate polyprenyl transferase
Mus musculus ENSMUSG00000029319   coenzyme Q2 homolog, prenyltransferase (yeast)
Neospora caninum NCLIV_027400   hypothetical protein
Oryza sativa 4345268   Os08g0322600
Plasmodium berghei PBANKA_0106100   4-hydroxybenzoate polyprenyltransferase, putative
Plasmodium falciparum PF3D7_0607500   4-hydroxybenzoate polyprenyltransferase, putative
Plasmodium knowlesi PKNH_1142800   4-hydroxybenzoate polyprenyltransferase, putative
Plasmodium vivax PVX_113540   para-hydroxybenzoate--polyprenyltransferase, putative
Plasmodium yoelii PY01399   4-hydroxybenzoate octaprenyltransferase
Saccharomyces cerevisiae YNR041C   4-hydroxybenzoate octaprenyltransferase
Schistosoma japonicum Sjp_0053800   ko:K06125 4-hydroxybenzoate hexaprenyltransferase, putative
Schmidtea mediterranea mk4.003632.00   4-hydroxybenzoate polyprenyltransferase, mitochondrial
Schmidtea mediterranea mk4.008400.00   4-hydroxybenzoate polyprenyltransferase, mitochondrial
Schmidtea mediterranea mk4.024928.00   4-hydroxybenzoate polyprenyltransferase, mitochondrial
Trypanosoma brucei gambiense Tbg972.11.10480   prenyltransferase, putative
Trypanosoma brucei Tb927.11.9360   prenyltransferase, putative
Trypanosoma congolense TcIL3000_0_44740   prenyltransferase, putative
Trypanosoma cruzi TcCLB.510903.60   prenyltransferase, putative
Trypanosoma cruzi TcCLB.505965.30   prenyltransferase, putative
Toxoplasma gondii TGME49_259130   4-hydroxybenzoate polyprenyl transferase
Theileria parva TP03_0802   4-hydroxybenzoate octaprenyltransferase, putative
Wolbachia endosymbiont of Brugia malayi Wbm0535   4-hydroxybenzoate polyprenyltransferase

Essentiality

TcCLB.510903.60 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.1130 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.1130 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.1130 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.1130 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
b4040 Escherichia coli essential goodall
PBANKA_0106100 Plasmodium berghei Essential plasmo
TGME49_259130 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TcCLB.510903.60 (Trypanosoma cruzi), prenyltransferase, putative
Title for this comment
Comment