pI: 8.5616 |
Length (AA): 100 |
MW (Da): 10700 |
Paralog Number:
5
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
11 | 99 | 1p3h (A) | 4 | 98 | 34.00 | 0 | 0.8 | 1.19 | -0.65 |
12 | 99 | 1we3 (O) | 8 | 100 | 36.00 | 0 | 1 | 1.32 | -0.4 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126769)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G14980 | chaperonin 10 |
Arabidopsis thaliana | AT5G20720 | chaperonin 20 |
Arabidopsis thaliana | AT1G23100 | GroES-like protein |
Babesia bovis | BBOV_I004480 | chaperonin, 10 kDa domain containing protein |
Babesia bovis | BBOV_III006630 | chaperonin, 10 kDa family protein |
Brugia malayi | Bm1_56470 | chaperonin-10 kDa |
Caenorhabditis elegans | CELE_Y22D7AL.10 | Protein Y22D7AL.10 |
Cryptosporidium hominis | Chro.70275 | hypothetical protein |
Cryptosporidium parvum | cgd7_2400 | chaperonin 10 Kd subunit, putative |
Chlamydia trachomatis | CT_111 | co-chaperonin GroES |
Dictyostelium discoideum | DDB_G0287811 | chaperonin 10 |
Dictyostelium discoideum | DDB_G0288265 | chaperonin 10 |
Drosophila melanogaster | Dmel_CG9920 | CG9920 gene product from transcript CG9920-RA |
Drosophila melanogaster | Dmel_CG11267 | CG11267 gene product from transcript CG11267-RA |
Escherichia coli | b4142 | Cpn10 chaperonin GroES, small subunit of GroESL |
Echinococcus granulosus | EgrG_000320800 | heat shock 10 kDa protein 1 |
Entamoeba histolytica | EHI_188880 | Chaperonin 10 Kd subunit, putative |
Echinococcus multilocularis | EmuJ_000320800 | heat shock 10 kDa protein 1 |
Homo sapiens | ENSG00000115541 | heat shock 10kDa protein 1 |
Leishmania braziliensis | LbrM.26.0630 | 10 kDa heat shock protein, putative |
Leishmania braziliensis | LbrM.26.0650 | 10 kDa heat shock protein, putative |
Leishmania donovani | LdBPK_260610.1 | 10 kDa heat shock protein, putative |
Leishmania infantum | LinJ.26.0610 | 10 kDa heat shock protein, putative |
Leishmania infantum | LinJ.26.0590 | 10 kDa heat shock protein, putative |
Leishmania major | LmjF.26.0620 | 10 kDa heat shock protein, putative |
Leishmania major | LmjF.26.0640 | 10 kDa heat shock protein, putative |
Leishmania mexicana | LmxM.26.0620 | 10 kDa heat shock protein, putative |
Mycobacterium leprae | ML0380 | 10 kD chaperonin GroES (Protein Cpn10) (groES protein) (BCG-A heat shock protein) (10 kDa antigen) |
Mus musculus | ENSMUSG00000073676 | heat shock protein 1 (chaperonin 10) |
Mus musculus | 623924 | predicted gene 6462 |
Mus musculus | 102635299 | predicted gene, 32676 |
Mycobacterium tuberculosis | Rv3418c | 10 kDa chaperonin GroES (protein CPN10) (protein GroES) (BCG-a heat shock protein) (10 kDa antigen) |
Mycobacterium ulcerans | MUL_0885 | co-chaperonin GroES |
Neospora caninum | NCLIV_033780 | YALI0B05610p, related |
Neospora caninum | NCLIV_024410 | 10 kDa chaperonin, related |
Oryza sativa | 4347161 | Os09g0438700 |
Oryza sativa | 4344071 | Os07g0641700 |
Oryza sativa | 4332912 | Os03g0366000 |
Oryza sativa | 4330925 | Os02g0781400 |
Oryza sativa | 4340394 | Os06g0196900 |
Onchocerca volvulus | OVOC9330 | 10 kDa heat shock protein, mitochondrial homolog |
Plasmodium berghei | PBANKA_1347800 | 20 kDa chaperonin, putative |
Plasmodium berghei | PBANKA_1431050 | 10 kDa chaperonin, putative |
Plasmodium falciparum | PF3D7_1215300 | 10 kDa chaperonin |
Plasmodium falciparum | PF3D7_1333000 | 20 kDa chaperonin |
Plasmodium knowlesi | PKNH_1267600 | 20 kDa chaperonin, putative |
Plasmodium knowlesi | PKNH_1434800 | 10 kDa chaperonin, putative |
Plasmodium vivax | PVX_123450 | 10 kDa chaperonin, putative |
Plasmodium vivax | PVX_082580 | 20 kDa chaperonin, putative |
Plasmodium yoelii | PY01850 | chaperonin, 10 kDa |
Plasmodium yoelii | PY02750 | chaperonin, 10 kDa |
Saccharomyces cerevisiae | YOR020C | Hsp10p |
Schistosoma japonicum | Sjp_0307410 | ko:K04078 chaperonin GroES, putative |
Schistosoma mansoni | Smp_097380 | groes chaperonin |
Schmidtea mediterranea | mk4.000007.08 | 10 kDa heat shock protein, mitochondrial |
Trypanosoma brucei gambiense | Tbg972.7.1300 | 10 kDa heat shock protein, putative |
Trypanosoma brucei gambiense | Tbg972.7.1280 | 10 kDa heat shock protein, putative |
Trypanosoma brucei | Tb927.7.1320 | 10 kDa heat shock protein, putative |
Trypanosoma brucei | Tb927.7.1340 | 10 kDa heat shock protein, putative |
Trypanosoma congolense | TcIL3000_7_940 | 10 kDa heat shock protein, putative |
Trypanosoma cruzi | TcCLB.509505.70 | 10 kDa heat shock protein, putative |
Trypanosoma cruzi | TcCLB.509505.50 | 10 kDa heat shock protein, putative |
Trypanosoma cruzi | TcCLB.508209.90 | 10 kDa heat shock protein, putative |
Trypanosoma cruzi | TcCLB.508209.100 | 10 kDa heat shock protein, putative |
Trypanosoma cruzi | TcCLB.508209.120 | 10 kDa heat shock protein, putative |
Trypanosoma cruzi | TcCLB.509505.30 | 10 kDa heat shock protein, putative |
Toxoplasma gondii | TGME49_263530 | chaperonin, putative |
Toxoplasma gondii | TGME49_273960 | chaperonin GroS protein |
Treponema pallidum | TP1013 | co-chaperonin GroES |
Theileria parva | TP02_0311 | chaperonin 20 precursor, putative |
Theileria parva | TP01_0190 | chaperonin 10 kDa, putative |
Trichomonas vaginalis | TVAG_392320 | groes chaperonin, putative |
Trichomonas vaginalis | TVAG_445730 | groes chaperonin, putative |
Trichomonas vaginalis | TVAG_041340 | groes chaperonin, putative |
Trichomonas vaginalis | TVAG_191660 | groes chaperonin, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0349 | co-chaperonin GroES |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.1320 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.1320 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.1320 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.1320 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b4142 | Escherichia coli | essential | goodall |
CELE_Y22D7AL.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
YOR020C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1347800 | Plasmodium berghei | Essential | plasmo |
TGME49_273960 | Toxoplasma gondii | Probably essential | sidik |
TGME49_263530 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Target | Type | Source | Notes |
---|---|---|---|
TcCLB.509505.70 | cloned gene | BRENDA | A gene with this EC number or name or sequence has been cloned from Trypanosoma cruzi ( 1 ) |