Detailed view for PF3D7_0724600

Basic information

TDR Targets ID: 451
Plasmodium falciparum, protein kinase, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.2565 | Length (AA): 2041 | MW (Da): 243554 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 20 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
450 1450 3bta (A) 237 1276 17.00 0.00000000014 0.89 0.53 1.02
1720 2035 2etr (A) 6 338 16.00 0.00000049 1 0.35 -0.47
1777 2040 1mq4 (A) 126 388 17.00 0 1 0.22 -1.48
757 1583 3s5m (A) 137 1001 20.00 0.00012 0.78 0.401194 1
1015 1280 4wat (A) 211 496 29.00 0.064 0.12 0.144328 0.66
1720 2036 3i6u (A) 148 487 18.00 0 1 0.259916 0.55
1780 2041 1o6l (A) 146 414 16.00 0 1 0.347968 -0.4
1780 2038 3daj (A) 127 386 19.00 0 1 0.340499 -0.54
1786 1985 2buj (A) 14 236 17.00 0.12 0.39 0.0256912 0.83
1800 1996 3zdu (A) 17 213 28.00 0.081 1 0.0245213 0.9
285 604 4o87 (A) 29 309 30.00 0.06 0.96 0.263625 0.57
655 1221 4om9 (A) 101 651 23.00 0.14 0.82 0.280061 1.28
1064 1322 4ija (A) 95 343 29.00 0.96 0.38 0.120635 0.92
1255 1404 4ux7 (A) 50 201 27.00 0.96 0.66 0.294946 0.34
1376 1626 4u0r (A) 183 494 19.00 0.078 0.03 0.227202 -0.19
1735 2034 4yhj (A) 135 454 18.00 0 1 0.310693 0.06
1773 2030 3zh8 (A) 239 515 17.00 0 1 0.357044 -0.51
1774 2030 1fot (A) 82 343 20.00 0 1 0.345552 -0.1
1783 1978 3cc6 (A) 428 627 13.00 0.12 0.18 0.0341618 0.52
1793 1989 3zdu (A) 17 213 28.00 0.079 1 0.0241535 0.9

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile early schizont, late schizont, late trophozoite. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile early ring, early trophozoite, late ring, Male Gametocyte. PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 40 hs, gametocyte, merozoite, sporozoite, Sporozoite. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 48 hs, Oocyst, Ring, Female Gametocyte. Otto TD Zanghi G Lasonder E
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_167094)

Species Accession Gene Product
Plasmodium berghei PBANKA_0622100   protein kinase, putative
Plasmodium falciparum PF3D7_0724600   protein kinase, putative
Plasmodium knowlesi PKNH_0320000   protein kinase, putative
Plasmodium vivax PVX_096115   protein kinase, putative
Plasmodium yoelii PY01615   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PF3D7_0724600 (Plasmodium falciparum), protein kinase, putative
Title for this comment
Comment