pI: 7.6328 |
Length (AA): 348 |
MW (Da): 39524 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | metacyclic. | Smircich P |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | epimastigote. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_129316)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G33640 | DHHC-type zinc finger family protein |
Babesia bovis | BBOV_I004680 | DHHC zinc finger domain containing protein |
Brugia malayi | Bm1_03315 | hypothetical protein |
Cryptosporidium hominis | Chro.40233 | hypothetical protein |
Cryptosporidium parvum | cgd4_2080 | DHHC family palmitoyl transferase with 4 transmembrane regions |
Drosophila melanogaster | Dmel_CG17075 | CG17075 gene product from transcript CG17075-RB |
Echinococcus granulosus | EgrG_001011400 | palmitoyltransferase zdhhc1 |
Echinococcus multilocularis | EmuJ_001011400 | palmitoyltransferase zdhhc1 |
Homo sapiens | ENSG00000188818 | zinc finger, DHHC-type containing 11 |
Homo sapiens | 653082 | zinc finger, DHHC-type containing 11B |
Homo sapiens | ENSG00000159714 | zinc finger, DHHC-type containing 1 |
Leishmania braziliensis | LbrM.22.1230 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_221200.1 | hypothetical protein, conserved |
Leishmania infantum | LinJ.22.1200 | hypothetical protein, conserved |
Leishmania major | LmjF.22.1350 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.22.1350 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_13842 | hypothetical protein |
Mus musculus | ENSMUSG00000039199 | zinc finger, DHHC domain containing 1 |
Mus musculus | ensembl-mmu:ENSMUSG00000069189 | zinc finger, DHHC domain containing 11 |
Neospora caninum | NCLIV_065580 | Zinc finger DHHC domain containing 12, related |
Plasmodium berghei | PBANKA_0927300 | palmitoyltransferase DHHC3 |
Plasmodium falciparum | PF3D7_1121000 | palmitoyltransferase DHHC3 |
Plasmodium knowlesi | PKNH_0918700 | palmitoyltransferase DHHC3, putative |
Plasmodium vivax | PVX_091670 | palmitoyltransferase, putative |
Plasmodium yoelii | PY03577 | unnamed protein product |
Schistosoma japonicum | Sjp_0309070 | Probable palmitoyltransferase ZDHHC1, putative |
Schistosoma japonicum | Sjp_0054730 | Probable palmitoyltransferase ZDHHC1, putative |
Schmidtea mediterranea | mk4.001828.05 | |
Trypanosoma brucei gambiense | Tbg972.7.3680 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.7.3350 | palmitoyl acyltransferase 11, putative |
Trypanosoma congolense | TcIL3000_7_2550 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.510533.230 | palmitoyl acyltransferase 11, putative |
Trypanosoma cruzi | TcCLB.511823.50 | palmitoyl acyltransferase 11, putative |
Toxoplasma gondii | TGME49_249380 | DHHC zinc finger domain-containing protein |
Theileria parva | TP03_0510 | hypothetical protein |
Trichomonas vaginalis | TVAG_221770 | zinc finger protein DHHC domain containing protein, putative |
Trichomonas vaginalis | TVAG_203860 | zinc finger protein DHHC domain containing protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.3350 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.3350 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.3350 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.3350 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_0927300 | Plasmodium berghei | Essential | plasmo |
TGME49_249380 | Toxoplasma gondii | Essentiality uncertain | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.