Detailed view for TcCLB.503493.10

Basic information

TDR Targets ID: 45185
Trypanosoma cruzi, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.5631 | Length (AA): 502 | MW (Da): 55862 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01704   UTP--glucose-1-phosphate uridylyltransferase

Gene Ontology

Mouse over links to read term descriptions.
GO:0070569   GO:uridylyltransferase activity  

GO:0008152   metabolic process  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 464 1jv1 (A) 82 499 19.00 0 1 0.83 -0.03
5 426 1jv1 (A) 85 501 18.00 0 1 0.87 -0.37
2 498 3ogz (A) 96 609 53.00 0 1 1.61844 -0.65

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_133365)

Species Accession Gene Product
Arabidopsis thaliana AT5G52560   UDP-sugar pyrophosphorylase
Cryptosporidium hominis Chro.70213   hypothetical protein
Cryptosporidium parvum cgd7_1830   secreted UDP-N-acetylglucosamine pyrophosphorylase family protein, signal peptide
Leishmania braziliensis LbrM.17.1270   UDP-sugar pyrophosphorylase
Leishmania donovani LdBPK_171260.1   UDP-sugar pyrophosphorylase
Leishmania infantum LinJ.17.1260   UDP-sugar pyrophosphorylase
Leishmania major LmjF.17.1160   UDP-sugar pyrophosphorylase
Leishmania mexicana LmxM.17.1160   hypothetical protein, conserved
Neospora caninum NCLIV_062050   UDP-N-acetylglucosamine pyrophosphorylase, putative
Oryza sativa 4341967   Os06g0701200
Plasmodium berghei PBANKA_1232300   UTP--glucose-1-phosphate uridylyltransferase, putative
Plasmodium falciparum PF3D7_0517500   UTP--glucose-1-phosphate uridylyltransferase, putative
Plasmodium knowlesi PKNH_1015800   UTP--glucose-1-phosphate uridylyltransferase, putative
Plasmodium vivax PVX_080375   UTP--glucose-1-phosphate uridylyltransferase, putative
Plasmodium yoelii PY05379   unknown protein-related
Trypanosoma cruzi TcCLB.503493.10   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511761.10   UDP-sugar pyrophosphorylase

Essentiality

TcCLB.503493.10 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1232300 Plasmodium berghei Dispensable plasmo
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.503493.10 (Trypanosoma cruzi), hypothetical protein, conserved
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