Detailed view for TcCLB.504013.60

Basic information

TDR Targets ID: 45582
Trypanosoma cruzi, regulatory subunit of protein kinase a-like protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 4.6866 | Length (AA): 558 | MW (Da): 62801 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00027   Cyclic nucleotide-binding domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
197 386 1q3e (A) 444 621 17.00 0 1 0.54 -0.06
256 534 1cx4 (A) 131 410 25.00 0 1 0.64 -0.59
260 521 1ne6 (A) 118 374 30.00 0 1 0.9 -0.67
143 183 4h33 (A) 38 78 10.00 0.0042 0 0.285177 -1.21
217 521 4din (B) 53 374 27.00 0 1 0.818095 0.51
237 532 2qvs (B) 93 392 24.00 0 1 0.769966 0.28
408 513 1o5l (A) 2 107 14.00 0 0.41 0.348464 -0.02
506 550 2zcw (A) 87 131 13.00 0.43 0 0.297345 -0.96

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_166709)

Species Accession Gene Product
Leishmania braziliensis LbrM.20.2440   regulatory subunit of protein kinase a-like protein
Leishmania donovani LdBPK_342680.1   regulatory subunit of protein kinase a-like protein
Leishmania infantum LinJ.34.2680   regulatory subunit of protein kinase a-like protein
Leishmania major LmjF.34.2820   regulatory subunit of protein kinase a-like protein
Leishmania mexicana LmxM.33.2820   regulatory subunit of protein kinase a-like protein
Trypanosoma cruzi TcCLB.510879.50   regulatory subunit of protein kinase a-like protein, putative
Trypanosoma cruzi TcCLB.504013.60   regulatory subunit of protein kinase a-like protein, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) epimastigote (BTO:0000409) inferred from in vitro culture assay (ECO:0000182) Trypanosoma cruzi 173061   458277  
Annotator: millerja@u.washington.edu. Comment: . References: 18694966

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

Known modulators for this target

Compound Source Reference
Curated by TDRTargets References
Curated by TDRTargets References

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus cAMP-dependent protein kinase A 401 aa 24.9% 362 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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User comments

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Gene identifier TcCLB.504013.60 (Trypanosoma cruzi), regulatory subunit of protein kinase a-like protein, putative
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