pI: 5.6106 |
Length (AA): 165 |
MW (Da): 19026 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
24 | 163 | 1p27 (A) | 5 | 144 | 53.00 | 0 | 1 | 1.65 | -1.82 |
20 | 164 | 1p27 (A) | 2 | 145 | 53.00 | 0 | 1 | 1.67069 | -1.73 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | epimastigote, metacyclic. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_128495)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G02140 | protein mago nashi |
Babesia bovis | BBOV_II003590 | mago nashi protein, putative |
Brugia malayi | Bm1_45810 | Mago nashi protein homolog |
Caenorhabditis elegans | CELE_R09B3.5 | Protein MAG-1 |
Dictyostelium discoideum | DDB_G0270866 | mago nashi protein |
Drosophila melanogaster | Dmel_CG9401 | mago nashi |
Echinococcus granulosus | EgrG_000481100 | protein mago nashi |
Entamoeba histolytica | EHI_138960 | mago nashi protein, putative |
Echinococcus multilocularis | EmuJ_000481100 | protein mago nashi |
Homo sapiens | ENSG00000162385 | mago-nashi homolog, proliferation-associated (Drosophila) |
Homo sapiens | ENSG00000111196 | mago-nashi homolog B (Drosophila) |
Leishmania braziliensis | LbrM.30.3590 | mago nashi-like protein, putative |
Leishmania donovani | LdBPK_303620.1 | mago nashi-like protein,putative |
Leishmania infantum | LinJ.30.3620 | mago nashi-like protein, putative |
Leishmania major | LmjF.30.3560 | mago nashi-like protein, putative |
Leishmania mexicana | LmxM.29.3560 | mago nashi-like protein, putative |
Loa Loa (eye worm) | LOAG_08619 | mm-Mago |
Mus musculus | ENSMUSG00000028609 | mago-nashi homolog, proliferation-associated (Drosophila) |
Mus musculus | ENSMUSG00000030188 | mago-nashi homolog B (Drosophila) |
Neospora caninum | NCLIV_038760 | mago nashi protein, putative |
Oryza sativa | 4344462 | Os08g0107900 |
Oryza sativa | 4351998 | Os12g0287200 |
Plasmodium berghei | PBANKA_0622700 | mago nashi protein homologue, putative |
Plasmodium falciparum | PF3D7_0725200 | mago nashi protein homologue, putative |
Plasmodium knowlesi | PKNH_0320600 | mago nashi protein homologue, putative |
Plasmodium vivax | PVX_096080 | mago nashi domain containing protein |
Plasmodium yoelii | PY03676 | mago nashi protein homolog |
Schistosoma japonicum | Sjp_0217400 | Protein mago nashi homolog 2, putative |
Schistosoma mansoni | Smp_103470.3 | hypothetical protein |
Schmidtea mediterranea | mk4.000002.35 | Mago nashi protein |
Trypanosoma brucei gambiense | Tbg972.6.4750 | mago nashi-like protein, putative |
Trypanosoma brucei | Tb927.6.4950 | Protein mago nashi homolog |
Trypanosoma congolense | TcIL3000_6_4380 | mago nashi-like protein, putative |
Trypanosoma cruzi | TcCLB.506945.200 | mago nashi-like protein, putative |
Toxoplasma gondii | TGME49_267420 | mago nashi family protein 2, putative |
Theileria parva | TP04_0225 | mago nashi protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.4950 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.4950 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.4950 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.4950 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_R09B3.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_R09B3.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_R09B3.5 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_R09B3.5 | Caenorhabditis elegans | slow growth | wormbase |
CELE_R09B3.5 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_0622700 | Plasmodium berghei | Slow | plasmo |
TGME49_267420 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.