Detailed view for TcCLB.508321.21
Basic information
TDR Targets ID: 46150
Trypanosoma cruzi, histone H2A, putative
Source Database / ID: TriTrypDB GeneDB
Trypanosoma cruzi, histone H2A, putative
Source Database / ID: TriTrypDB GeneDB
pI: 11.8845 |
Length (AA): 135 |
MW (Da): 14394 |
Paralog Number:
13
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Gene Ontology
Mouse over links to read term descriptions.
GO:0046982
protein heterodimerization activity GO:0005634 nucleus
GO:0000786 nucleosome
GO:0003677 DNA binding
GO:0006334 nucleosome assembly
Metabolic Pathways
This gene is not mapped to any metabolic pathway in KEGG.
Structural information
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 17 | 132 | 1id3 (C) | 16 | 125 | 55.00 | 0 | 1 | 1.42 | 0.31 |
| 24 | 91 | 1f1e (A) | 80 | 144 | 22.00 | 0.000078 | 0.17 | 0.79 | -0.95 |
| 2 | 131 | 1kx5 (C) | 2 | 127 | 50.00 | 0 | 0.96 | 1.38056 | 1.16 |
| 3 | 109 | 4m6b (A) | 117 | 221 | 44.00 | 0 | 1 | 1.27179 | 0.22 |
| 12 | 122 | 2f8n (G) | 1012 | 1118 | 55.00 | 0 | 0.96 | 1.33382 | 0.67 |
Help me make sense of these data.
Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
No structure availble in the PDB for this protein
Expression
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Upper 60-80% percentile | epimastigote. | Smircich P |
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Lower 20-40% percentile | metacyclic. | Smircich P |
-
Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.
Orthologs
Ortholog group members (OG5_126570)
| Species | Accession | Gene Product |
|---|---|---|
| Arabidopsis thaliana | AT1G51060 | histone H2A 10 |
| Arabidopsis thaliana | AT4G27230 | histone H2A 2 |
| Arabidopsis thaliana | AT5G54640 | histone H2A 1 |
| Arabidopsis thaliana | AT1G08880 | putative histone H2AXa |
| Arabidopsis thaliana | AT3G20670 | histone H2A 13 |
| Arabidopsis thaliana | AT1G54690 | gamma histone variant H2AX |
| Arabidopsis thaliana | AT5G59870 | histone H2A 6 |
| Arabidopsis thaliana | AT5G02560 | histone H2A 12 |
| Babesia bovis | BBOV_II001900 | Histone H2A protein |
| Brugia malayi | Bm1_20820 | Histone H2A |
| Brugia malayi | Bm1_02505 | histone H2A |
| Brugia malayi | Bm1_20285 | histone H2A |
| Candida albicans | CaO19.8653 | one of two closely related histone genes similar to S. cerevisiae HTA1 (YDR225W) and HTA2 (YBL003C) histone H2A |
| Candida albicans | CaO19.6924 | one of two closely related histone genes similar to S. cerevisiae HTA1 (YDR225W) and HTA2 (YBL003C) histone H2A |
| Candida albicans | CaO19.14186 | one of two closely related histone genes similar to S. cerevisiae HTA1 (YDR225W) and HTA2 (YBL003C) histone H2A |
| Candida albicans | CaO19.1051 | one of two closely related histone genes similar to S. cerevisiae HTA1 (YDR225W) and HTA2 (YBL003C) histone H2A |
| Caenorhabditis elegans | CELE_F07B7.3 | Protein HIS-53 |
| Caenorhabditis elegans | CELE_F35H10.1 | Protein HIS-30 |
| Caenorhabditis elegans | CELE_F55G1.10 | Protein HIS-61 |
| Caenorhabditis elegans | CELE_K06C4.3 | Protein HIS-21 |
| Caenorhabditis elegans | CELE_ZK131.6 | Protein HIS-12 |
| Caenorhabditis elegans | CELE_K06C4.11 | Protein HIS-19 |
| Caenorhabditis elegans | CELE_ZK1251.1 | Protein HTAS-1 |
| Caenorhabditis elegans | CELE_F08G2.2 | Protein HIS-43 |
| Caenorhabditis elegans | CELE_F45F2.4 | Protein HIS-7 |
| Caenorhabditis elegans | CELE_T10C6.12 | Protein HIS-3 |
| Caenorhabditis elegans | CELE_H02I12.7 | Protein HIS-65 |
| Caenorhabditis elegans | CELE_T23D8.6 | Protein HIS-68 |
| Caenorhabditis elegans | CELE_C50F4.13 | Protein HIS-35 |
| Caenorhabditis elegans | CELE_F17E9.13 | Protein HIS-33 |
| Caenorhabditis elegans | CELE_F54E12.5 | Protein HIS-57, isoform A |
| Caenorhabditis elegans | CELE_B0035.7 | Protein HIS-47 |
| Caenorhabditis elegans | CELE_F07B7.10 | Protein HIS-51 |
| Caenorhabditis elegans | CELE_ZK131.10 | Protein HIS-16 |
| Cryptosporidium hominis | Chro.80256 | histone h2a |
| Cryptosporidium parvum | cgd8_2170 | histone H2A |
| Dictyostelium discoideum | DDB_G0279667 | histone H2A |
| Dictyostelium discoideum | DDB_G0289187 | histone H2A domain-containing protein |
| Drosophila melanogaster | Dmel_CG31618 | CG31618 gene product from transcript CG31618-RA |
| Drosophila melanogaster | Dmel_CG33838 | CG33838 gene product from transcript CG33838-RA |
| Drosophila melanogaster | Dmel_CG33823 | CG33823 gene product from transcript CG33823-RA |
| Drosophila melanogaster | Dmel_CG33844 | CG33844 gene product from transcript CG33844-RA |
| Drosophila melanogaster | Dmel_CG33829 | CG33829 gene product from transcript CG33829-RA |
| Drosophila melanogaster | Dmel_CG33850 | CG33850 gene product from transcript CG33850-RA |
| Drosophila melanogaster | Dmel_CG33859 | CG33859 gene product from transcript CG33859-RA |
| Drosophila melanogaster | Dmel_CG33847 | CG33847 gene product from transcript CG33847-RA |
| Drosophila melanogaster | Dmel_CG33814 | CG33814 gene product from transcript CG33814-RA |
| Drosophila melanogaster | Dmel_CG33832 | CG33832 gene product from transcript CG33832-RA |
| Drosophila melanogaster | Dmel_CG33835 | CG33835 gene product from transcript CG33835-RA |
| Drosophila melanogaster | Dmel_CG33817 | CG33817 gene product from transcript CG33817-RA |
| Drosophila melanogaster | Dmel_CG33856 | CG33856 gene product from transcript CG33856-RA |
| Drosophila melanogaster | Dmel_CG33808 | CG33808 gene product from transcript CG33808-RA |
| Drosophila melanogaster | Dmel_CG33841 | CG33841 gene product from transcript CG33841-RA |
| Drosophila melanogaster | Dmel_CG33820 | CG33820 gene product from transcript CG33820-RA |
| Drosophila melanogaster | Dmel_CG33826 | CG33826 gene product from transcript CG33826-RA |
| Drosophila melanogaster | Dmel_CG33853 | CG33853 gene product from transcript CG33853-RA |
| Drosophila melanogaster | Dmel_CG33865 | CG33865 gene product from transcript CG33865-RA |
| Drosophila melanogaster | Dmel_CG33862 | CG33862 gene product from transcript CG33862-RA |
| Echinococcus granulosus | EgrG_000209600 | histone cluster h2aj |
| Echinococcus granulosus | EgrG_000472600 | histone H2A |
| Echinococcus granulosus | EgrG_002060700 | histone H2A |
| Echinococcus granulosus | EgrG_002051200 | histone H2A |
| Echinococcus granulosus | EgrG_000472900 | histone H2A |
| Echinococcus granulosus | EgrG_002051500 | histone H2A |
| Echinococcus granulosus | EgrG_000650200 | histone H2A |
| Entamoeba histolytica | EHI_126210 | histone H2A, putative |
| Entamoeba histolytica | EHI_188960 | histone H2A, putative |
| Echinococcus multilocularis | EmuJ_000027600 | histone H2A |
| Echinococcus multilocularis | EmuJ_000383900 | histone H2A |
| Echinococcus multilocularis | EmuJ_000031800 | histone H2A |
| Echinococcus multilocularis | EmuJ_000032100 | histone H2A |
| Echinococcus multilocularis | EmuJ_000367200 | histone H2A |
| Echinococcus multilocularis | EmuJ_000337000 | histone H2A |
| Echinococcus multilocularis | EmuJ_000306200 | |
| Echinococcus multilocularis | EmuJ_001201500 | histone H2A |
| Echinococcus multilocularis | EmuJ_000336800 | histone H2A |
| Echinococcus multilocularis | EmuJ_000472600 | histone H2A |
| Echinococcus multilocularis | EmuJ_000034100 | histone H2A |
| Echinococcus multilocularis | EmuJ_000031000 | Histone H2A type 1 |
| Echinococcus multilocularis | EmuJ_000683600 | histone H2A |
| Echinococcus multilocularis | EmuJ_000650300 | histone H2A |
| Echinococcus multilocularis | EmuJ_000336600 | histone H2A |
| Echinococcus multilocularis | EmuJ_000279200 | histone H2A |
| Echinococcus multilocularis | EmuJ_000709900 | histone H2A |
| Echinococcus multilocularis | EmuJ_000472900 | histone H2A |
| Echinococcus multilocularis | EmuJ_000336400 | histone H2A |
| Echinococcus multilocularis | EmuJ_000384200 | histone H2A |
| Echinococcus multilocularis | EmuJ_000367500 | histone H2A |
| Echinococcus multilocularis | EmuJ_000032200 | histone H2A |
| Echinococcus multilocularis | EmuJ_000029500 | histone H2A |
| Echinococcus multilocularis | EmuJ_000209600 | histone cluster h2aj histone cluster h2ah histone cluster h2ag |
| Echinococcus multilocularis | EmuJ_000650200 | histone H2A |
| Echinococcus multilocularis | EmuJ_000383600 | histone H2A |
| Giardia lamblia | GL50803_27521 | Histone H2A |
| Giardia lamblia | GL50803_14256 | Histone H2A |
| Homo sapiens | ENSG00000184260 | histone cluster 2, H2ac |
| Homo sapiens | 3013 | histone cluster 1, H2ad |
| Homo sapiens | 55766 | H2A histone family, member J |
| Homo sapiens | 221613 | histone cluster 1, H2aa |
| Homo sapiens | ENSG00000188486 | H2A histone family, member X |
| Homo sapiens | ENSG00000272196 | histone cluster 2, H2aa4 |
| Homo sapiens | 8334 | histone cluster 1, H2ac |
| Homo sapiens | ENSG00000276903 | histone cluster 1, H2al |
| Homo sapiens | 3012 | histone cluster 1, H2ae |
| Homo sapiens | ENSG00000203812 | histone cluster 2, H2aa3 |
| Homo sapiens | ENSG00000196747 | histone cluster 1, H2ai |
| Homo sapiens | ENSG00000278463 | histone cluster 1, H2ab |
| Homo sapiens | ENSG00000274997 | histone cluster 1, H2ah |
| Homo sapiens | 92815 | histone cluster 3, H2a |
| Homo sapiens | 8969 | histone cluster 1, H2ag |
| Homo sapiens | ENSG00000184270 | histone cluster 2, H2ab |
| Homo sapiens | ENSG00000276368 | histone cluster 1, H2aj |
| Homo sapiens | ENSG00000275221 | histone cluster 1, H2ak |
| Homo sapiens | ENSG00000278677 | histone cluster 1, H2am |
| Leishmania braziliensis | LbrM.32.1270 | histone H2A, putative |
| Leishmania braziliensis | LbrM.21.1150 | histone H2A, putative |
| Leishmania braziliensis | LbrM.29.1820 | histone H2A, putative |
| Leishmania braziliensis | LbrM.21.1140 | histone H2A |
| Leishmania braziliensis | LbrM.29.1810 | histone H2A, putative |
| Leishmania braziliensis | LbrM.21.1160 | histone H2A, putative |
| Leishmania braziliensis | LbrM.32.1260 | histone H2A, putative |
| Leishmania donovani | LdBPK_211170.1 | histone H2A, putative |
| Leishmania donovani | LdBPK_211160.1 | histone H2A |
| Leishmania infantum | LinJ.21.1160 | histone H2A |
| Leishmania infantum | LinJ.21.1170 | histone H2A, putative |
| Leishmania major | LmjF.29.1730 | histone H2A, putative |
| Leishmania major | LmjF.29.1720 | histone H2A, putative |
| Leishmania major | LmjF.29.1740 | histone H2A, putative |
| Leishmania major | LmjF.21.0915 | histone H2A |
| Leishmania major | LmjF.21.0920 | histone H2A, putative |
| Leishmania major | LmjF.21.0930 | histone H2A, putative |
| Leishmania mexicana | LmxM.08_29.1740 | histone H2A, putative |
| Leishmania mexicana | LmxM.21.0920 | histone H2A, putative |
| Leishmania mexicana | LmxM.08_29.1730 | histone H2A, putative |
| Leishmania mexicana | LmxM.08_29.1720 | histone H2A, putative |
| Loa Loa (eye worm) | LOAG_15693 | histone H2A isoform 1 |
| Loa Loa (eye worm) | LOAG_16111 | histone 2A |
| Loa Loa (eye worm) | LOAG_14621 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_06256 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_15196 | histone H2A isoform 1 |
| Loa Loa (eye worm) | LOAG_14714 | histone H2A isoform 1 |
| Loa Loa (eye worm) | LOAG_10010 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_10471 | histone H2A |
| Mus musculus | ENSMUSG00000064220 | histone cluster 2, H2aa2 |
| Mus musculus | ENSMUSG00000063689 | histone cluster 2, H2ab |
| Mus musculus | 319176 | histone cluster 2, H2ac |
| Mus musculus | ENSMUSG00000049932 | H2A histone family, member X |
| Mus musculus | ENSMUSG00000061615 | histone cluster 1, H2ab |
| Mus musculus | ENSMUSG00000069309 | histone cluster 1, H2an |
| Mus musculus | ENSMUSG00000060032 | H2A histone family, member J |
| Mus musculus | ENSMUSG00000061991 | histone cluster 1, H2af |
| Mus musculus | 100504109 | predicted gene 11336 |
| Mus musculus | ENSMUSG00000063954 | histone cluster 2, H2aa1 |
| Mus musculus | 319166 | histone cluster 1, H2ae |
| Mus musculus | ENSMUSG00000078851 | histone cluster 3, H2a |
| Mus musculus | 667728 | histone cluster 1, H2al |
| Mus musculus | ENSMUSG00000060081 | histone cluster 1, H2aa |
| Mus musculus | 319164 | histone cluster 1, H2ac |
| Mus musculus | ENSMUSG00000069301 | histone cluster 1, H2ag |
| Mus musculus | ENSMUSG00000069302 | histone cluster 1, H2ah |
| Mus musculus | ENSMUSG00000094777 | histone cluster 1, H2ap |
| Mus musculus | ENSMUSG00000071516 | histone cluster 1, H2ai |
| Mus musculus | ENSMUSG00000071478 | histone cluster 1, H2ad |
| Mus musculus | 665433 | histone cluster 1, H2ao |
| Mus musculus | ENSMUSG00000063021 | histone cluster 1, H2ak |
| Neospora caninum | NCLIV_025910 | Histone H2A, related |
| Neospora caninum | NCLIV_026140 | Histone H2A, related |
| Oryza sativa | 4324481 | Os01g0502700 |
| Oryza sativa | 4343519 | Os07g0545400 |
| Oryza sativa | 4343518 | Os07g0545300 |
| Oryza sativa | 4352398 | Os12g0530000 |
| Oryza sativa | 4352128 | Os12g0438000 |
| Oryza sativa | 4337607 | Os05g0113900 |
| Oryza sativa | 4339022 | Os05g0461400 |
| Oryza sativa | 4332433 | Os03g0279200 |
| Oryza sativa | 4333939 | Os03g0721900 |
| Onchocerca volvulus | OVOC1238 |
|
| Onchocerca volvulus | OVOC7892 |
|
| Onchocerca volvulus | OVOC7794 |
|
| Onchocerca volvulus | OVOC1234 |
|
| Plasmodium berghei | PBANKA_1117000 | histone H2A, putative |
| Plasmodium falciparum | PF3D7_0617800 | histone H2A |
| Plasmodium knowlesi | PKNH_1132600 | histone H2A, putative |
| Plasmodium vivax | PVX_114015 | histone H2A, putative |
| Plasmodium yoelii | PY05076 | histone h2a |
| Saccharomyces cerevisiae | YDR225W | histone H2A |
| Saccharomyces cerevisiae | YBL003C | histone H2A |
| Schistosoma japonicum | Sjp_0114330 | Histone H2A, putative |
| Schistosoma japonicum | Sjp_0048860 | Histone H2A type 2-B, putative |
| Schistosoma japonicum | Sjp_0076290 | Histone H2A, putative |
| Schistosoma japonicum | Sjp_0063130 | Histone H2A type 1, putative |
| Schistosoma japonicum | Sjp_0040210 | Histone H2A, putative |
| Schistosoma japonicum | Sjp_0063110 | Histone H2A type 2-B, putative |
| Schistosoma mansoni | Smp_002930 | histone H2A |
| Schistosoma mansoni | Smp_089840 | histone H2A |
| Schistosoma mansoni | Smp_089870 | histone H2A |
| Schistosoma mansoni | Smp_086860 | histone H2A |
| Schmidtea mediterranea | mk4.000901.00 | |
| Schmidtea mediterranea | mk4.000167.01 | |
| Schmidtea mediterranea | mk4.000102.21 | Histone H2A |
| Schmidtea mediterranea | mk4.019915.02 | |
| Schmidtea mediterranea | mk4.001646.01 | |
| Schmidtea mediterranea | mk4.000124.05 | |
| Schmidtea mediterranea | mk4.010068.00 | |
| Schmidtea mediterranea | mk4.014794.00 | Histone H2A |
| Schmidtea mediterranea | mk4.000696.08 | |
| Schmidtea mediterranea | mk4.024181.00 | |
| Schmidtea mediterranea | mk4.011130.01 | |
| Schmidtea mediterranea | mk4.002225.01 | |
| Schmidtea mediterranea | mk4.006303.00 | |
| Schmidtea mediterranea | mk4.018403.01 | |
| Schmidtea mediterranea | mk4.013901.00 | |
| Schmidtea mediterranea | mk4.008818.01 | |
| Schmidtea mediterranea | mk4.035649.00 | |
| Schmidtea mediterranea | mk4.027700.00 | |
| Schmidtea mediterranea | mk4.028562.01 | |
| Schmidtea mediterranea | mk4.000586.04 | |
| Schmidtea mediterranea | mk4.024306.01 | |
| Schmidtea mediterranea | mk4.011354.00 | |
| Schmidtea mediterranea | mk4.000031.07 | Histone H2A |
| Schmidtea mediterranea | mk4.017079.00 | |
| Schmidtea mediterranea | mk4.000444.07 | |
| Schmidtea mediterranea | mk4.010468.00 | |
| Schmidtea mediterranea | mk4.000628.07 | Histone H2A |
| Schmidtea mediterranea | mk4.016810.05 | |
| Schmidtea mediterranea | mk4.004629.01 | |
| Schmidtea mediterranea | mk4.002922.00 | |
| Schmidtea mediterranea | mk4.007909.00 | |
| Schmidtea mediterranea | mk4.024058.00 | Histone H2A |
| Schmidtea mediterranea | mk4.000910.04 | |
| Schmidtea mediterranea | mk4.001314.04 | |
| Schmidtea mediterranea | mk4.000301.11 | Histone H2A |
| Schmidtea mediterranea | mk4.000573.01 | Histone H2A |
| Schmidtea mediterranea | mk4.008811.02 | |
| Schmidtea mediterranea | mk4.002385.04 | |
| Schmidtea mediterranea | mk4.040346.00 | |
| Schmidtea mediterranea | mk4.000985.16 | Histone H2A |
| Schmidtea mediterranea | mk4.003169.00 | |
| Schmidtea mediterranea | mk4.002046.01 | |
| Schmidtea mediterranea | mk4.013376.00 | |
| Schmidtea mediterranea | mk4.025746.01 | |
| Schmidtea mediterranea | mk4.000103.01 | |
| Schmidtea mediterranea | mk4.006729.01 | |
| Schmidtea mediterranea | mk4.011499.00 | |
| Schmidtea mediterranea | mk4.008902.00 | Histone H2A |
| Schmidtea mediterranea | mk4.000503.19 | |
| Schmidtea mediterranea | mk4.002959.02 | Histone H2A |
| Schmidtea mediterranea | mk4.000259.09 | |
| Schmidtea mediterranea | mk4.015024.00 | Histone H2A |
| Schmidtea mediterranea | mk4.000696.10 | |
| Schmidtea mediterranea | mk4.001642.00 | |
| Schmidtea mediterranea | mk4.001499.01 | |
| Schmidtea mediterranea | mk4.017677.02 | |
| Schmidtea mediterranea | mk4.000129.03 | |
| Schmidtea mediterranea | mk4.001285.04 | Histone H2A |
| Schmidtea mediterranea | mk4.045984.00 | |
| Schmidtea mediterranea | mk4.002568.06 | |
| Schmidtea mediterranea | mk4.020750.00 | |
| Schmidtea mediterranea | mk4.000059.14 | |
| Schmidtea mediterranea | mk4.004873.02 | |
| Schmidtea mediterranea | mk4.008251.01 | |
| Schmidtea mediterranea | mk4.006761.00 | |
| Schmidtea mediterranea | mk4.000480.03 | Histone H2A |
| Schmidtea mediterranea | mk4.000899.10 | |
| Schmidtea mediterranea | mk4.013851.07 | Histone H2A |
| Schmidtea mediterranea | mk4.001297.02 | |
| Schmidtea mediterranea | mk4.032889.00 | Histone H2A |
| Schmidtea mediterranea | mk4.014132.00 | |
| Schmidtea mediterranea | mk4.000337.10 | |
| Schmidtea mediterranea | mk4.004660.01 | |
| Schmidtea mediterranea | mk4.000546.21 | |
| Schmidtea mediterranea | mk4.011360.00 | |
| Schmidtea mediterranea | mk4.020573.01 | |
| Schmidtea mediterranea | mk4.019478.00 | Histone H2A |
| Schmidtea mediterranea | mk4.010335.01 | |
| Schmidtea mediterranea | mk4.004520.00 | |
| Schmidtea mediterranea | mk4.008943.00 | |
| Schmidtea mediterranea | mk4.030341.00 | |
| Schmidtea mediterranea | mk4.009795.00 | |
| Schmidtea mediterranea | mk4.011929.03 | |
| Schmidtea mediterranea | mk4.003804.04 | Histone H2A |
| Schmidtea mediterranea | mk4.014851.00 | Histone H2A |
| Schmidtea mediterranea | mk4.002373.00 | |
| Schmidtea mediterranea | mk4.020889.01 | |
| Schmidtea mediterranea | mk4.024604.00 | |
| Schmidtea mediterranea | mk4.020443.00 | Histone H2A |
| Schmidtea mediterranea | mk4.019679.01 | |
| Schmidtea mediterranea | mk4.002800.00 | |
| Schmidtea mediterranea | mk4.043068.01 | |
| Schmidtea mediterranea | mk4.023072.00 | |
| Schmidtea mediterranea | mk4.007699.00 | Histone H2A |
| Schmidtea mediterranea | mk4.002498.01 | |
| Schmidtea mediterranea | mk4.000813.08 | |
| Schmidtea mediterranea | mk4.020659.03 | |
| Schmidtea mediterranea | mk4.012857.00 | |
| Schmidtea mediterranea | mk4.009396.00 | |
| Schmidtea mediterranea | mk4.012803.01 | |
| Schmidtea mediterranea | mk4.000900.01 | |
| Schmidtea mediterranea | mk4.043126.00 | |
| Schmidtea mediterranea | mk4.012657.00 | |
| Schmidtea mediterranea | mk4.001262.06 | |
| Schmidtea mediterranea | mk4.005523.00 | |
| Schmidtea mediterranea | mk4.003568.03 | Histone H2A |
| Schmidtea mediterranea | mk4.014899.00 | |
| Schmidtea mediterranea | mk4.024390.00 | |
| Schmidtea mediterranea | mk4.017535.00 | Histone H2A |
| Schmidtea mediterranea | mk4.013824.00 | |
| Schmidtea mediterranea | mk4.000160.09 | Histone H2A |
| Schmidtea mediterranea | mk4.018759.00 | Histone H2A |
| Schmidtea mediterranea | mk4.000973.08 | |
| Schmidtea mediterranea | mk4.019624.00 | Histone H2A |
| Schmidtea mediterranea | mk4.004754.04 | |
| Schmidtea mediterranea | mk4.002847.03 | |
| Schmidtea mediterranea | mk4.015042.00 | |
| Schmidtea mediterranea | mk4.005181.01 | |
| Schmidtea mediterranea | mk4.010360.00 | Histone H2A |
| Schmidtea mediterranea | mk4.006861.00 | |
| Schmidtea mediterranea | mk4.017302.00 | |
| Schmidtea mediterranea | mk4.016020.00 | |
| Schmidtea mediterranea | mk4.016918.01 | |
| Schmidtea mediterranea | mk4.009098.02 | |
| Schmidtea mediterranea | mk4.002455.01 | |
| Schmidtea mediterranea | mk4.027196.00 | |
| Schmidtea mediterranea | mk4.011619.01 | |
| Schmidtea mediterranea | mk4.002898.02 | |
| Schmidtea mediterranea | mk4.010006.01 | |
| Schmidtea mediterranea | mk4.030979.00 | Histone H2A |
| Schmidtea mediterranea | mk4.024106.01 | |
| Schmidtea mediterranea | mk4.000056.00 | Histone H2A |
| Schmidtea mediterranea | mk4.000876.00 | Histone H2A |
| Schmidtea mediterranea | mk4.009142.04 | |
| Schmidtea mediterranea | mk4.024448.00 | |
| Schmidtea mediterranea | mk4.000056.09 | Histone H2A |
| Schmidtea mediterranea | mk4.032105.00 | Histone H2A |
| Schmidtea mediterranea | mk4.009656.00 | Histone H2A |
| Schmidtea mediterranea | mk4.000350.12 | |
| Schmidtea mediterranea | mk4.018219.01 | |
| Schmidtea mediterranea | mk4.002052.00 | Histone H2A |
| Schmidtea mediterranea | mk4.032362.00 | Histone H2A |
| Schmidtea mediterranea | mk4.000389.01 | |
| Schmidtea mediterranea | mk4.003696.00 | |
| Schmidtea mediterranea | mk4.000928.10 | |
| Schmidtea mediterranea | mk4.003642.01 | |
| Schmidtea mediterranea | mk4.001761.02 | |
| Schmidtea mediterranea | mk4.004225.02 | Histone H2A |
| Schmidtea mediterranea | mk4.006950.00 | |
| Schmidtea mediterranea | mk4.026528.01 | |
| Schmidtea mediterranea | mk4.004364.00 | Histone H2A |
| Schmidtea mediterranea | mk4.033540.00 | |
| Schmidtea mediterranea | mk4.010442.00 | |
| Schmidtea mediterranea | mk4.003443.01 | |
| Schmidtea mediterranea | mk4.024869.00 | |
| Schmidtea mediterranea | mk4.003682.00 | |
| Schmidtea mediterranea | mk4.033241.00 | |
| Schmidtea mediterranea | mk4.043795.00 | |
| Schmidtea mediterranea | mk4.008399.02 | |
| Schmidtea mediterranea | mk4.041017.00 | |
| Schmidtea mediterranea | mk4.003116.02 | |
| Schmidtea mediterranea | mk4.021383.00 | |
| Schmidtea mediterranea | mk4.006188.02 | |
| Schmidtea mediterranea | mk4.007728.00 | Histone H2A |
| Schmidtea mediterranea | mk4.000422.11 | Histone H2A |
| Schmidtea mediterranea | mk4.019733.00 | |
| Schmidtea mediterranea | mk4.009270.00 | Histone H2A |
| Schmidtea mediterranea | mk4.001713.04 | |
| Schmidtea mediterranea | mk4.013070.01 | |
| Schmidtea mediterranea | mk4.016263.01 | |
| Schmidtea mediterranea | mk4.011239.01 | |
| Schmidtea mediterranea | mk4.000688.04 | |
| Schmidtea mediterranea | mk4.001252.05 | |
| Schmidtea mediterranea | mk4.023376.00 | |
| Schmidtea mediterranea | mk4.009269.01 | |
| Schmidtea mediterranea | mk4.000100.09 | |
| Schmidtea mediterranea | mk4.016231.00 | |
| Schmidtea mediterranea | mk4.010787.00 | |
| Schmidtea mediterranea | mk4.018087.00 | Histone H2A |
| Schmidtea mediterranea | mk4.005494.07 | |
| Schmidtea mediterranea | mk4.005310.01 | |
| Schmidtea mediterranea | mk4.000653.05 | Histone H2A |
| Schmidtea mediterranea | mk4.028756.00 | |
| Schmidtea mediterranea | mk4.003000.02 | |
| Schmidtea mediterranea | mk4.004866.01 | Histone H2A |
| Schmidtea mediterranea | mk4.008019.00 | |
| Schmidtea mediterranea | mk4.000861.06 | Histone H2A |
| Schmidtea mediterranea | mk4.009756.00 | Histone H2A |
| Schmidtea mediterranea | mk4.002368.03 | |
| Schmidtea mediterranea | mk4.022413.00 | |
| Schmidtea mediterranea | mk4.001455.03 | Histone H2A |
| Schmidtea mediterranea | mk4.002088.01 | |
| Schmidtea mediterranea | mk4.012122.00 | Histone H2A |
| Schmidtea mediterranea | mk4.011416.01 | |
| Schmidtea mediterranea | mk4.032859.00 | Histone H2A |
| Schmidtea mediterranea | mk4.000086.10 | Histone H2A |
| Schmidtea mediterranea | mk4.001438.00 | Histone H2A |
| Schmidtea mediterranea | mk4.010079.02 | |
| Schmidtea mediterranea | mk4.004850.06 | |
| Schmidtea mediterranea | mk4.021972.02 | |
| Schmidtea mediterranea | mk4.022214.00 | |
| Schmidtea mediterranea | mk4.000268.06 | |
| Schmidtea mediterranea | mk4.004173.01 | Histone H2A |
| Schmidtea mediterranea | mk4.001436.00 | |
| Schmidtea mediterranea | mk4.008168.04 | |
| Schmidtea mediterranea | mk4.026348.00 | |
| Schmidtea mediterranea | mk4.012497.00 | |
| Schmidtea mediterranea | mk4.010465.00 | |
| Schmidtea mediterranea | mk4.001587.02 | |
| Schmidtea mediterranea | mk4.004315.05 | |
| Schmidtea mediterranea | mk4.021772.02 | |
| Schmidtea mediterranea | mk4.007436.00 | |
| Schmidtea mediterranea | mk4.005542.00 | |
| Schmidtea mediterranea | mk4.006492.01 | Histone H2A |
| Schmidtea mediterranea | mk4.009889.01 | |
| Schmidtea mediterranea | mk4.021210.00 | Histone H2A |
| Schmidtea mediterranea | mk4.000066.09 | |
| Schmidtea mediterranea | mk4.009608.02 | Histone H2A |
| Schmidtea mediterranea | mk4.001021.00 | |
| Schmidtea mediterranea | mk4.013297.00 | Histone H2A |
| Schmidtea mediterranea | mk4.007648.00 | |
| Schmidtea mediterranea | mk4.000045.11 | Histone H2A |
| Schmidtea mediterranea | mk4.002880.01 | |
| Schmidtea mediterranea | mk4.000038.12 | |
| Schmidtea mediterranea | mk4.012112.00 | |
| Schmidtea mediterranea | mk4.000468.01 | |
| Schmidtea mediterranea | mk4.000772.06 | |
| Schmidtea mediterranea | mk4.002221.00 | Histone H2A |
| Schmidtea mediterranea | mk4.000610.06 | |
| Schmidtea mediterranea | mk4.030165.00 | Histone H2A |
| Schmidtea mediterranea | mk4.003365.00 | |
| Schmidtea mediterranea | mk4.002596.01 | |
| Schmidtea mediterranea | mk4.001519.05 | |
| Schmidtea mediterranea | mk4.018961.00 | Histone H2A |
| Schmidtea mediterranea | mk4.012034.07 | Histone H2A |
| Schmidtea mediterranea | mk4.000661.08 | |
| Schmidtea mediterranea | mk4.005994.01 | |
| Schmidtea mediterranea | mk4.000371.06 | |
| Schmidtea mediterranea | mk4.010814.00 | Histone H2A |
| Trypanosoma brucei gambiense | Tbg972.7.3220 | histone H2A, putative |
| Trypanosoma brucei gambiense | Tbg972.7.3230 | histone H2A, putative |
| Trypanosoma brucei gambiense | Tbg972.7.3250 | histone H2A, putative |
| Trypanosoma brucei gambiense | Tbg972.7.3260 | histone H2A, putative |
| Trypanosoma brucei gambiense | Tbg972.7.3240 | histone H2A, putative |
| Trypanosoma brucei | Tb927.7.2890 | histone H2A, putative |
| Trypanosoma brucei | Tb927.7.2820 | histone H2A, putative |
| Trypanosoma brucei | Tb927.7.2830 | histone H2A, putative |
| Trypanosoma brucei | Tb927.7.2910 | histone H2A, putative |
| Trypanosoma brucei | Tb927.7.2940 | histone H2A, putative |
| Trypanosoma brucei | Tb927.7.2870 | histone H2A, putative |
| Trypanosoma brucei | Tb927.7.2930 | histone H2A, putative |
| Trypanosoma brucei | Tb927.7.2900 | histone H2A, putative |
| Trypanosoma brucei | Tb927.7.2880 | histone H2A, putative |
| Trypanosoma brucei | Tb927.7.2850 | histone H2A, putative |
| Trypanosoma brucei | Tb927.7.2860 | histone H2A, putative |
| Trypanosoma brucei | Tb927.7.2840 | histone H2A, putative |
| Trypanosoma brucei | Tb927.7.2920 | histone H2A, putative |
| Trypanosoma congolense | TcIL3000_7_2140 | histone H2A, putative |
| Trypanosoma cruzi | TcCLB.508321.21 | histone H2A, putative |
| Trypanosoma cruzi | TcCLB.510525.110 | histone H2A, putative |
| Trypanosoma cruzi | TcCLB.511817.140 | histone H2A, putative |
| Trypanosoma cruzi | TcCLB.511817.151 | histone H2A, putative |
| Trypanosoma cruzi | TcCLB.511809.135 | histone H2A, putative |
| Trypanosoma cruzi | TcCLB.509207.20 | histone H2A, putative |
| Trypanosoma cruzi | TcCLB.510525.80 | histone H2A, putative |
| Trypanosoma cruzi | TcCLB.511817.161 | histone H2A, putative |
| Trypanosoma cruzi | TcCLB.511817.180 | histone H2A, putative |
| Trypanosoma cruzi | TcCLB.511817.171 | histone H2A, putative |
| Trypanosoma cruzi | TcCLB.510525.100 | histone H2A, putative |
| Trypanosoma cruzi | TcCLB.510525.90 | histone H2A, putative |
| Trypanosoma cruzi | TcCLB.509207.11 | histone H2A, putative |
| Trypanosoma cruzi | TcCLB.511809.140 | histone H2A, putative |
| Toxoplasma gondii | TGME49_261580 | histone H2AX |
| Toxoplasma gondii | TGME49_261250 | histone H2A1 |
| Theileria parva | TP04_0322 | Histone H2A, putative |
| Trichomonas vaginalis | TVAG_329280 | histone H2a, putative |
| Trichomonas vaginalis | TVAG_026380 | histone H2a, putative |
| Trichomonas vaginalis | TVAG_105970 | histone H2a, putative |
| Trichomonas vaginalis | TVAG_055220 | histone H2a, putative |
| Trichomonas vaginalis | TVAG_462660 | histone H2a, putative |
| Trichomonas vaginalis | TVAG_195310 | histone H2a, putative |
| Trichomonas vaginalis | TVAG_380930 | histone H2a, putative |
| Trichomonas vaginalis | TVAG_075280 | histone H2a, putative |
| Trichomonas vaginalis | TVAG_464710 | histone H2a, putative |
| Trichomonas vaginalis | TVAG_389620 | histone H2a, putative |
| Trichomonas vaginalis | TVAG_226790 | histone H2a, putative |
| Trichomonas vaginalis | TVAG_144030 | histone H2a, putative |
| Trichomonas vaginalis | TVAG_321400 | histone H2a, putative |
| Trichomonas vaginalis | TVAG_045400 | histone H2a, putative |
| Trichomonas vaginalis | TVAG_447860 | histone H2a, putative |
| Trichomonas vaginalis | TVAG_381770 | histone H2a, putative |
| Trichomonas vaginalis | TVAG_021440 | histone H2a, putative |
Essentiality
TcCLB.508321.21 has one or more orthologs with essentiality data
| Gene/Ortholog | Organism | Phenotype | Source Study |
|---|---|---|---|
| Tb927.7.2820 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
| Tb927.7.2820 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
| Tb927.7.2820 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
| Tb927.7.2820 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
| CELE_T10C6.12 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_T10C6.12 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_T10C6.12 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_T10C6.12 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_T10C6.12 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F45F2.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F45F2.4 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F45F2.4 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_F45F2.4 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F45F2.4 | Caenorhabditis elegans | sterile | wormbase |
| CELE_ZK131.6 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_ZK131.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_ZK131.6 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_ZK131.10 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_ZK131.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_K06C4.11 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_K06C4.11 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_K06C4.11 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_K06C4.11 | Caenorhabditis elegans | sterile | wormbase |
| CELE_K06C4.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_K06C4.3 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_K06C4.3 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_K06C4.3 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F35H10.1 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_F35H10.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F35H10.1 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F17E9.13 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_F17E9.13 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F17E9.13 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F17E9.13 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F17E9.13 | Caenorhabditis elegans | sterile | wormbase |
| CELE_C50F4.13 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_C50F4.13 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_C50F4.13 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F08G2.2 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_F08G2.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F08G2.2 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_B0035.7 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_B0035.7 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_B0035.7 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_B0035.7 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_B0035.7 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F07B7.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F07B7.10 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F07B7.10 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F07B7.10 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F07B7.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F07B7.3 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F07B7.3 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F54E12.5 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_F54E12.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F54E12.5 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F54E12.5 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F54E12.5 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F55G1.10 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_F55G1.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F55G1.10 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F55G1.10 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F55G1.10 | Caenorhabditis elegans | sterile | wormbase |
| CELE_H02I12.7 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_H02I12.7 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_H02I12.7 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_H02I12.7 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_H02I12.7 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_H02I12.7 | Caenorhabditis elegans | sterile | wormbase |
| CELE_T23D8.6 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_T23D8.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_T23D8.6 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_T23D8.6 | Caenorhabditis elegans | sterile | wormbase |
| YBL003C | Saccharomyces cerevisiae | inviable | yeastgenome |
| PBANKA_1117000 | Plasmodium berghei | Slow | plasmo |
| TGME49_261250 | Toxoplasma gondii | Probably essential | sidik |
| TGME49_261580 | Toxoplasma gondii | Probably essential | sidik |
| TGME49_261250 | Toxoplasma gondii | Probably non-essential | sidik |
| TGME49_261580 | Toxoplasma gondii | Probably non-essential | sidik |
-
nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource -
blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930 -
yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database -
keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection -
gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84 -
neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs -
shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan -
wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170 -
alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
Phenotypes and Validation (curated)
We have no manually annotated phenotypes for this target.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
No validation data for this target
Associated compounds / Druggability
Known modulators for this target
No chemical compounds associated to this gene
Predicted associations
By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model
Assayability
Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
Bibliographic References
No literature references available for this target.
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User comments
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