Detailed view for TcCLB.511003.190

Basic information

TDR Targets ID: 46185
Trypanosoma cruzi, aldose 1-epimerase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.2083 | Length (AA): 291 | MW (Da): 32532 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01263   Aldose 1-epimerase

Gene Ontology

Mouse over links to read term descriptions.
GO:0030246   carbohydrate binding  
GO:0016853   isomerase activity  
GO:0003824   catalytic activity  
GO:0005975   carbohydrate metabolic process  

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 284 2cir (A) 6 288 28.00 0 1 1.3 -0.93
4 285 2hta (A) 24 291 27.00 0 1 1.35707 -0.97
4 286 1jov (A) 19 269 32.00 0.000000000038 1 1.24851 -0.05
13 284 2cir (A) 16 288 29.00 0 1 1.27191 -0.79
24 261 2hta (A) 43 267 36.00 0 1 1.20587 -0.37

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128336)

Species Accession Gene Product
Arabidopsis thaliana AT4G23730   galactose mutarotase-like superfamily protein
Arabidopsis thaliana AT5G66530   aldose 1-epimerase family protein
Arabidopsis thaliana AT3G01590   galactose mutarotase-like superfamily protein
Arabidopsis thaliana AT5G14500   aldose 1-epimerase family protein
Arabidopsis thaliana AT3G61610   galactose mutarotase-like superfamily protein
Arabidopsis thaliana AT5G57330   galactose mutarotase-like superfamily protein
Candida albicans CaO19.9501   similar to S. cerevisiae YMR099c
Candida albicans CaO19.1946   similar to S. cerevisiae YMR099c
Dictyostelium discoideum DDB_G0277669   aldose 1-epimerase family protein
Drosophila melanogaster Dmel_CG9008   CG9008 gene product from transcript CG9008-RA
Escherichia coli b1780   D-hexose-6-phosphate epimerase-like protein
Leishmania braziliensis LbrM.20.2970   aldose 1-epimerase-like protein
Leishmania donovani LdBPK_343160.1   aldose 1-epimerase-like protein
Leishmania infantum LinJ.34.3160   aldose 1-epimerase-like protein
Leishmania major LmjF.34.3380   aldose 1-epimerase-like protein
Leishmania mexicana LmxM.33.3380   aldose 1-epimerase-like protein
Oryza sativa 4327164   Os01g0658700
Oryza sativa 9269126   Os08g0241500
Oryza sativa 9268618   Os04g0603000
Oryza sativa 4337265   Os04g0658000
Oryza sativa 4346747   Os09g0327400
Saccharomyces cerevisiae YMR099C   glucose-6-phosphate 1-epimerase
Trypanosoma brucei gambiense Tbg972.4.1190   hypothetical protein, conserved
Trypanosoma brucei Tb927.4.1360   Glucose-6-phosphate 1-epimerase, putative
Trypanosoma congolense TcIL3000_4_860   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511003.190   aldose 1-epimerase, putative

Essentiality

TcCLB.511003.190 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.1360 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.1360 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.4.1360 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.1360 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
b1780 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

  • Tcru021505AAA;
  • Type Source Notes
    soluble recombinant protein Structural Genomics for Pathogenic Protozoa (SGPP) Tcru021505; Recombinant protein: full-length; Source: T cruzi; Aldose 1-epimerase ;

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.511003.190 (Trypanosoma cruzi), aldose 1-epimerase, putative
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