Detailed view for PF3D7_0629500

Basic information

TDR Targets ID: 4644
Plasmodium falciparum, amino acid transporter, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 10.1491 | Length (AA): 606 | MW (Da): 68858 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 9

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01490   Transmembrane amino acid transporter protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0015171   amino acid transmembrane transporter activity  
GO:0006865   amino acid transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
167 593 2a65 (A) 7 468 11.00 0.000000045 0.02 0.93 -2.25
1 159 4fyf (A) 471 625 17.00 0 0.02 0.453676 -1.38
17 135 3fhn (A) 76 191 13.00 0 0.02 0.41067 -1.75
1 137 4o87 (A) 47 203 32.00 0.23 0.13 0.293173 -0.42
3 103 3ik2 (A) 392 494 24.00 0.72 0.01 0.421767 -0.45
9 133 3na7 (A) 1 132 19.00 0.47 0.02 0.539371 -2.12
170 606 3gia (A) 9 414 14.00 0 0.5 0.680722 -0.37

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, sporozoite, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Oocyst, Sporozoite, Female Gametocyte. Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Male Gametocyte. Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_129703)

Species Accession Gene Product
Candida albicans CaO19.1210   similar to transmembrane amino acid transporters that control amino acid flux in vacuolar-like organelles
Candida albicans CaO19.8799   similar to transmembrane amino acid transporters that control amino acid flux in vacuolar-like organelles
Cryptosporidium hominis Chro.80017   hypothetical protein
Cryptosporidium parvum cgd8_80   10 transmembrane domain, possible aa transporter
Leishmania braziliensis LbrM.31.0750   amino acid transporter aATP11, putative
Leishmania braziliensis LbrM.07.1240   amino acid transporter, putative
Leishmania donovani LdBPK_310610.1   amino acid transporter aATP11, putative
Leishmania donovani LdBPK_071340.1   amino acid transporter 19, putative
Leishmania infantum LinJ.31.0610   amino acid transporter aATP11, putative
Leishmania infantum LinJ.07.1340   amino acid transporter, putative
Leishmania major LmjF.31.0580   amino acid transporter aATP11, putative
Leishmania major LmjF.07.1160   amino acid transporter, putative
Leishmania mexicana LmxM.30.0580   amino acid transporter aATP11, putative
Leishmania mexicana LmxM.07.1160   transmembrane amino acid transporter, putative
Plasmodium falciparum PF3D7_0629500   amino acid transporter, putative
Plasmodium vivax PVX_114575   transmembrane amino acid transporter protein, putative
Saccharomyces cerevisiae YER119C   Avt6p
Saccharomyces cerevisiae YIL088C   Avt7p
Saccharomyces cerevisiae YBL089W   Avt5p
Trypanosoma brucei gambiense Tbg972.8.8590   amino acid transporter, putative
Trypanosoma brucei gambiense Tbg972.8.8580   amino acid transporter, putative
Trypanosoma brucei gambiense Tbg972.8.8570   amino acid transporter, putative
Trypanosoma brucei gambiense Tbg972.8.8600   amino acid transporter, putative
Trypanosoma brucei gambiense Tbg972.8.8550   amino acid transporter, putative
Trypanosoma brucei gambiense Tbg972.8.8560   amino acid transporter, putative
Trypanosoma brucei Tb927.8.8220   amino acid transporter, putative
Trypanosoma brucei Tb927.8.8240   amino acid transporter, putative
Trypanosoma brucei Tb927.8.8230   amino acid transporter, putative
Trypanosoma brucei Tb927.8.8250   amino acid transporter, putative
Trypanosoma brucei Tb927.8.8260   amino acid transporter, putative
Trypanosoma congolense TcIL3000_10_13900   amino acid transporter, putative
Trypanosoma cruzi TcCLB.510507.40   transmembrane amino acid transporter, putative
Trypanosoma cruzi TcCLB.509463.10   transmembrane amino acid transporter, putative
Trypanosoma cruzi TcCLB.507811.100   amino acid permease, putative
Trypanosoma cruzi TcCLB.511649.100   amino acid permease, putative

Essentiality

PF3D7_0629500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.8220 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.8220 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.8220 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.8220 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_0629500 (Plasmodium falciparum), amino acid transporter, putative
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