Detailed view for TcCLB.509561.30
Basic information
Trypanosoma cruzi, citrate transporter, putative
Source Database / ID: TriTrypDB GeneDB
pI: 10.3239 |
Length (AA): 401 |
MW (Da): 44768 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 3
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
Gene Ontology
GO:0005743 mitochondrial inner membrane
GO:0005488 binding
GO:0055085 transmembrane transport
GO:0006810 transport
Metabolic Pathways
Structural information
Modbase 3D models:
PDB Structures:
Expression
Orthologs
Ortholog group members (OG5_129733)
| Species | Accession | Gene Product |
|---|---|---|
| Brugia malayi | Bm1_23965 | tricarboxylate transport protein, mitochondrial precursor |
| Candida albicans | CaO19.5870 | likely mitochondrial citrate transporter similar to S. cerevisiae CTP1 (YBR291C) |
| Candida albicans | CaO19.13291 | likely mitochondrial citrate transporter similar to S. cerevisiae CTP1 (YBR291C) |
| Caenorhabditis elegans | CELE_K11H3.3 | Protein K11H3.3 |
| Drosophila melanogaster | Dmel_CG6782 | scheggia |
| Echinococcus granulosus | EgrG_000902600 | tricarboxylate transport protein |
| Echinococcus multilocularis | EmuJ_000902600 | tricarboxylate transport protein |
| Homo sapiens | ENSG00000100075 | solute carrier family 25 (mitochondrial carrier |
| Loa Loa (eye worm) | LOAG_03395 | hypothetical protein |
| Mus musculus | ENSMUSG00000003528 | solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 |
| Onchocerca volvulus | OVOC7693 | Tricarboxylate transport protein, mitochondrial homolog |
| Saccharomyces cerevisiae | YBR291C | Ctp1p |
| Schistosoma mansoni | Smp_149320 | tricarboxylate transport protein |
| Trypanosoma cruzi | TcCLB.509561.30 | citrate transporter, putative |
| Trypanosoma cruzi | TcCLB.503897.170 | citrate transporter, putative |
Essentiality
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Druggability index (range: 0 to 1): 0.5
Known modulators for this target
Predicted associations
By orthology with druggable targets
By sequence similarity to non orthologous druggable targets
Obtained from network model
Assayability
Assay information
Reagent availability
Bibliographic References