pI: 6.9046 |
Length (AA): 2536 |
MW (Da): 300925 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 15 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1211 | 1433 | 1q0u (A) | 4 | 212 | 16.00 | 0 | 0.24 | 0.11 | -1.35 |
1233 | 1407 | 2fz4 (A) | 93 | 229 | 20.00 | 0.000098 | 0.9 | 0.17 | -1.03 |
37 | 1068 | 4un4 (B) | 251 | 1358 | 11.00 | 0 | 0.98 | -0.11656 | 2.22 |
1178 | 1738 | 4a2q (A) | 130 | 789 | 18.00 | 0.73 | 0.99 | 0.193315 | 1.17 |
26 | 1014 | 3v0a (A) | 275 | 1260 | 16.00 | 0.0000000015 | 0.82 | 0.309084 | 1.84 |
806 | 980 | 4uos (A) | 2 | 172 | 22.00 | 0.54 | 0.04 | 0.343106 | -1.39 |
1170 | 2250 | 2xgj (A) | 84 | 965 | 19.00 | 0 | 1 | -0.0916382 | 2.19 |
1205 | 2326 | 4a4z (A) | 302 | 1218 | 21.00 | 0 | 1 | -0.065471 | 2.39 |
1223 | 1795 | 2zj8 (A) | 10 | 568 | 17.00 | 0.00000019 | 1 | 0.163046 | 0.94 |
1232 | 1532 | 4buj (E) | 328 | 668 | 27.00 | 0.00015 | 1 | 0.179391 | 1.01 |
1238 | 1416 | 4f92 (B) | 1332 | 1504 | 25.00 | 0.45 | 1 | 0.220284 | -0.28 |
1249 | 1439 | 2zj2 (A) | 40 | 212 | 31.00 | 0.032 | 0.85 | 0.292015 | -0.2 |
1741 | 2028 | 4buj (A) | 619 | 1145 | 29.00 | 0.000001 | 0.86 | 0.149265 | 1.22 |
1743 | 1937 | 4bgd (A) | 710 | 912 | 20.00 | 0.00096 | 0.27 | 0.160993 | -0.06 |
1800 | 1914 | 2p6r (A) | 265 | 383 | 35.00 | 0.001 | 0.99 | 0.404047 | 0.12 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, sporozoite, Sporozoite. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, merozoite, early ring, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, early schizont, Male Gametocyte. | Otto TD PlasmoDB Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Female Gametocyte. | Lasonder E |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Ortholog group members (OG5_130134)
Species | Accession | Gene Product |
---|---|---|
Babesia bovis | BBOV_III001710 | DEAD/DEAH box helicase domain containing protein |
Brugia malayi | Bm1_15640 | DEAD/DEAH box helicase family protein |
Caenorhabditis elegans | CELE_C28H8.3 | Protein C28H8.3 |
Cryptosporidium hominis | Chro.50172 | DEAD/DEAH box helicase |
Cryptosporidium parvum | cgd5_2070 | SPAC694.02. SKI family SFII helicase |
Dictyostelium discoideum | DDB_G0278827 | hypothetical protein |
Homo sapiens | ENSG00000181381 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like |
Homo sapiens | ENSG00000137628 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 |
Leishmania braziliensis | LbrM.03.0590 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_030670.1 | DEAD/DEAH box helicase, putative |
Leishmania infantum | LinJ.03.0670 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.03.0690 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_05056 | hypothetical protein |
Loa Loa (eye worm) | LOAG_05055 | hypothetical protein |
Loa Loa (eye worm) | LOAG_04199 | hypothetical protein |
Loa Loa (eye worm) | LOAG_14683 | hypothetical protein |
Mus musculus | ENSMUSG00000037921 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 |
Neospora caninum | NCLIV_001370 | DEAD/DEAH box helicase, putative |
Onchocerca volvulus | OVOC9164 | Uncharacterized helicase homolog |
Plasmodium berghei | PBANKA_0418000 | ATP-dependent RNA helicase DDX60, putative |
Plasmodium falciparum | PF3D7_0903400 | ATP-dependent RNA helicase DDX60, putative |
Plasmodium knowlesi | PKNH_0701100 | ATP-dependent RNA helicase DDX60, putative |
Plasmodium vivax | PVX_098615 | DEAD/DEAH box helicase, putative |
Plasmodium yoelii | PY01108 | DEAD/DEAH box helicase, putative |
Trypanosoma brucei gambiense | Tbg972.3.2650 | ATP-dependent DEAD/H RNA helicase, putative |
Trypanosoma brucei | Tb927.3.2600 | ATP-dependent DEAD/H RNA helicase, putative |
Trypanosoma cruzi | TcCLB.508153.1050 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.510313.20 | hypothetical protein, conserved |
Toxoplasma gondii | TGME49_294350 | DEAD/DEAH box helicase domain-containing protein |
Theileria parva | TP03_0667 | DEAD box RNA helicase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.3.2600 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.2600 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.2600 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.3.2600 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_0418000 | Plasmodium berghei | Essential | plasmo |
TGME49_294350 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.5
171 literature references were collected for this gene.