Detailed view for PF3D7_0728600

Basic information

TDR Targets ID: 472
Plasmodium falciparum, RING zinc finger protein, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.2173 | Length (AA): 2162 | MW (Da): 253974 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13445   RING-type zinc-finger

Gene Ontology

Mouse over links to read term descriptions.
GO:0030414   protease inhibitor activity  
GO:0008270   zinc ion binding  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2101 2159 2ct2 (A) 15 74 31.00 0.00000067 0.53 0.43 -0.67
4 175 4u5a (C) 48 239 20.00 0.23 0.26 0.231456 -0.62
137 673 3zuq (A) 283 881 17.00 0.00022 0.93 0.180281 1.45
228 335 3ult (A) 11 118 19.00 0.2 0.04 0.252654 -0.5
230 1215 3s5m (A) 129 1190 22.00 0.47 0.97 0.398759 1.56
265 429 3uau (A) 160 304 32.00 0.53 0.19 -0.0949818 1.22
1423 1568 3fby (A) 299 483 38.00 0.000096 0.01 -0.0177699 1.98
1562 1948 4gf2 (A) 226 716 31.00 0.0066 0.11 0.0897009 1.02
1845 2059 4tql (A) 10 231 19.00 0.004 0.07 0.340345 -1.1
2098 2159 2ct2 (A) 12 74 29.00 0.59 0.48 0.327577 -0.17

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile gametocyte, sporozoite, early schizont, late trophozoite, Sporozoite, Female Gametocyte, Male Gametocyte. PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile early trophozoite, late schizont, Oocyst. PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 32 hs, merozoite. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Ring. Otto TD Zanghi G
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_160903)

Species Accession Gene Product
Plasmodium berghei PBANKA_0212700   RING zinc finger protein, putative
Plasmodium falciparum PF3D7_0728600   RING zinc finger protein, putative
Plasmodium knowlesi PKNH_0213200   RING zinc finger protein, putative
Plasmodium vivax PVX_081725   hypothetical protein, conserved
Plasmodium yoelii PY02958   erythrocyte membrane protein 3

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0728600 (Plasmodium falciparum), RING zinc finger protein, putative
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