pI: 10.0823 |
Length (AA): 629 |
MW (Da): 71788 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
25 | 405 | 1nex (B) | 340 | 706 | 13.00 | 0 | 0.78 | 0.63 | 0.36 |
46 | 350 | 1erj (A) | 314 | 707 | 16.00 | 0 | 1 | 0.7 | -0.33 |
108 | 402 | 2h14 (A) | 38 | 334 | 16.00 | 0 | 1 | 0.73 | -0.52 |
241 | 311 | 1k8k (C) | 9 | 81 | 27.00 | 0 | 0.73 | 0.414378 | -0.39 |
249 | 309 | 5tf2 (A) | 163 | 222 | 35.00 | 0.0028 | 0.56 | 0.462579 | 0.23 |
502 | 588 | 5wsu (C) | 764 | 850 | 9.00 | 0 | 0 | 0.398815 | -2.23 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | metacyclic. | Smircich P |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | epimastigote. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_127796)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G10530 | transducin/WD40 domain-containing protein |
Babesia bovis | BBOV_III002170 | conserved hypothetical protein |
Brugia malayi | Bm1_06510 | WD-repeat protein BING4 |
Brugia malayi | Bm1_06505 | WD-repeat protein BING4 |
Candida albicans | CaO19.4835 | similar to S. cerevisiae UTP7 component of U3 snoRNP involved in rRNA processing |
Candida albicans | CaO19.12298 | similar to S. cerevisiae UTP7 component of U3 snoRNP involved in rRNA processing |
Caenorhabditis elegans | CELE_F28D1.1 | Protein WDR-46 |
Cryptosporidium hominis | Chro.70456 | YER082C |
Cryptosporidium parvum | cgd7_4110 | WD40 protein (part of U3 processesome) |
Dictyostelium discoideum | DDB_G0280489 | BING4 C-terminal domain-containing protein |
Drosophila melanogaster | Dmel_CG2260 | CG2260 gene product from transcript CG2260-RA |
Echinococcus granulosus | EgrG_000586000 | WD repeat containing protein 46 |
Entamoeba histolytica | EHI_027730 | WD repeat protein |
Echinococcus multilocularis | EmuJ_000586000 | WD repeat containing protein 46 |
Giardia lamblia | GL50803_15513 | WD-repeat protein BING4 |
Homo sapiens | ENSG00000227057 | WD repeat domain 46 |
Leishmania braziliensis | LbrM.11.0230 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_230790.1 | WD domain, G-beta repeat/BING4CT (NUC141) domain containing protein, putative |
Leishmania infantum | LinJ.23.0790 | hypothetical protein, conserved |
Leishmania major | LmjF.23.0620 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.23.0620 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_09257 | hypothetical protein |
Loa Loa (eye worm) | LOAG_13662 | hypothetical protein |
Loa Loa (eye worm) | LOAG_10197 | WD-repeat protein BING4 |
Mus musculus | ENSMUSG00000024312 | WD repeat domain 46 |
Neospora caninum | NCLIV_037710 | WD domain, G-beta repeat-containing protein, putative |
Oryza sativa | 4325333 | Os01g0183100 |
Plasmodium berghei | PBANKA_0620100 | U3 small nucleolar RNA-associated protein 7, putative |
Plasmodium falciparum | PF3D7_0722600 | U3 small nucleolar RNA-associated protein 7, putative |
Plasmodium knowlesi | PKNH_0318000 | U3 small nucleolar RNA-associated protein 7, putative |
Plasmodium vivax | PVX_096225 | hypothetical protein, conserved |
Plasmodium yoelii | PY02268 | hypothetical protein |
Saccharomyces cerevisiae | YER082C | Utp7p |
Schistosoma japonicum | Sjp_0021490 | WD repeat-containing protein 46, putative |
Schistosoma mansoni | Smp_120350 | hypothetical protein |
Schmidtea mediterranea | mk4.002012.01 | |
Trypanosoma brucei gambiense | Tbg972.8.2090 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.8.2600 | WD domain, G-beta repeat/BING4CT (NUC141) domain containing protein, putative |
Trypanosoma congolense | TcIL3000_8_2400 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.508045.30 | WD domain, G-beta repeat/BING4CT (NUC141) domain containing protein, putative |
Trypanosoma cruzi | TcCLB.503829.40 | WD domain, G-beta repeat/BING4CT (NUC141) domain containing protein, putative |
Toxoplasma gondii | TGME49_268640 | BING4CT (NUC141) domain-containing protein |
Theileria parva | TP03_0576 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_301400 | U3 small nucleolar RNA-associated protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.2600 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.2600 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.2600 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.2600 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F28D1.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F28D1.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F28D1.1 | Caenorhabditis elegans | slow growth | wormbase |
YER082C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_268640 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.