Detailed view for PF3D7_0907600

Basic information

TDR Targets ID: 4751
Plasmodium falciparum, translation initiation factor SUI1, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.4514 | Length (AA): 818 | MW (Da): 95282 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01253   Translation initiation factor SUI1

Gene Ontology

Mouse over links to read term descriptions.
GO:0003743   translation initiation factor activity  
GO:0003723   RNA binding  
GO:0006413   translational initiation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 15 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 170 1iq8 (A) 423 582 12.00 0 0.25 0.1 -0.32
10 179 2cx0 (A) 13 180 23.00 0 1 0.4 -1.02
713 814 2if1 () 25 123 20.00 0 0.68 0.31 -1.04
1 184 3r90 (A) 1 185 21.00 0.000000029 1 0.498239 -0.41
11 176 3d79 (A) 6 169 30.00 0.01 1 0.437834 -0.25
278 585 4u06 (A) 52 356 21.00 0.65 1 0.399428 0.97
548 723 4uos (A) 2 182 19.00 0.099 0.56 0.509459 -1.36
731 803 4mo0 (A) 26 91 26.00 0.38 1 0.356542 -0.55
1 184 3r90 (A) 1 185 21.00 0.00000014 1 0.49669 -0.43
11 175 3d79 (A) 6 168 27.00 0.0000043 1 0.492406 -0.72
13 175 2cx0 (A) 16 176 26.00 0.0018 1 0.455955 -0.38
212 689 2vse (A) 240 795 28.00 0.0072 0.22 0.400084 1.97
320 654 4u09 (A) 93 406 26.00 0.063 1 0.466839 0.93
475 691 4tql (A) 11 235 17.00 0.036 0.77 0.500131 -0.59
546 724 4uos (A) 2 182 18.00 0.19 0.36 0.480563 -1.17

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 8 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 16 hs, merozoite, sporozoite, early ring, late ring, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, gametocyte, early schizont, early trophozoite, late schizont, late trophozoite, Oocyst, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Sporozoite. Otto TD Zanghi G
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_129088)

Species Accession Gene Product
Arabidopsis thaliana AT1G71350   eukaryotic translation initiation factor SUI1 family protein
Babesia bovis BBOV_II005360   hypothetical protein
Brugia malayi Bm1_46640   Translation initiation factor SUI1 family protein
Candida albicans CaO19.12008   similar to S. cerevisiae YDR117C
Candida albicans CaO19.4533   similar to S. cerevisiae YDR117C
Caenorhabditis elegans CELE_C25H3.4   Protein C25H3.4
Cryptosporidium hominis Chro.40020   hypothetical protein
Cryptosporidium parvum cgd4_70   conserved hypothetical protein
Dictyostelium discoideum DDB_G0287639   hypothetical protein
Drosophila melanogaster Dmel_CG31426   CG31426 gene product from transcript CG31426-RA
Echinococcus granulosus EgrG_000705100   eukaryotic translation initiation factor 2d
Echinococcus granulosus EgrG_000705200   eukaryotic translation initiation factor 2d
Echinococcus multilocularis EmuJ_000705200   eukaryotic translation initiation factor 2d
Echinococcus multilocularis EmuJ_000705100   eukaryotic translation initiation factor 2d
Homo sapiens ENSG00000143486   eukaryotic translation initiation factor 2D
Loa Loa (eye worm) LOAG_09150   translation initiation factor SUI1 family protein
Loa Loa (eye worm) LOAG_10461   hypothetical protein
Mus musculus ENSMUSG00000026427   eukaryotic translation initiation factor 2D
Neospora caninum NCLIV_011560   GM12258, related
Neospora caninum NCLIV_011570   Ligatin, related
Oryza sativa 4329675   Os02g0557600
Onchocerca volvulus OVOC9834   Eukaryotic translation initiation factor 2D homolog
Plasmodium berghei PBANKA_0809000   translation initiation factor SUI1, putative
Plasmodium falciparum PF3D7_0907600   translation initiation factor SUI1, putative
Plasmodium knowlesi PKNH_0705400   translation initiation factor SUI1, putative
Plasmodium vivax PVX_098825   hypothetical protein, conserved
Plasmodium yoelii PY04116   hepatocellular carcinoma-associated antigen 56A
Saccharomyces cerevisiae YDR117C   Tma64p
Schistosoma japonicum Sjp_0315680   IPR001950,Translation initiation factor SUI1,domain-containing
Schistosoma japonicum Sjp_0020230   Ligatin, putative
Schistosoma mansoni Smp_155400   ligatin
Schmidtea mediterranea mk4.005372.00   Eukaryotic translation initiation factor 2D
Schmidtea mediterranea mk4.012822.00   Eukaryotic translation initiation factor 2D
Toxoplasma gondii TGME49_211410   translation initiation factor sui1 protein

Essentiality

PF3D7_0907600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0809000 Plasmodium berghei Dispensable plasmo
TGME49_211410 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PF3D7_0907600 (Plasmodium falciparum), translation initiation factor SUI1, putative
Title for this comment
Comment