Detailed view for NCLIV_034530

Basic information

TDR Targets ID: 475609
Neospora caninum, TCP-1/cpn60 family chaperonin, putative
Source Database / ID: 

pI: 6.6564 | Length (AA): 542 | MW (Da): 58492 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00118   TCP-1/cpn60 chaperonin family

Gene Ontology

Mouse over links to read term descriptions.
GO:0051082   unfolded protein binding  
GO:0005524   ATP binding  
GO:0006457   protein folding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
18 542 4b2t (D) 21 542 60.00 0 1 1.57163 -0.06
28 539 1a6d (A) 18 519 40.00 0 1 1.49265 -0.71
28 542 1q3q (A) 19 525 40.00 0 1 1.48578 -0.76

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127832)

Species Accession Gene Product
Arabidopsis thaliana AT3G18190   TCP-1/cpn60 chaperonin family protein
Babesia bovis BBOV_IV005030   T-complex protein 1 delta subunit, putative
Brugia malayi Bm1_17890   T-complex protein 1, delta subunit
Candida albicans CaO19.10235   similar to S. cerevisiae CCT4 (YDL143W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol
Candida albicans CaO19.2720   similar to S. cerevisiae CCT4 (YDL143W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol
Caenorhabditis elegans CELE_K01C8.10   Protein CCT-4
Cryptosporidium hominis Chro.50193   chaperonin containing TCP-1 delta subunit
Cryptosporidium parvum cgd5_1880   conserved probable chaperonin containing TCP-1 delta subunit
Dictyostelium discoideum DDB_G0292872   chaperonin containing TCP1 delta subunit
Drosophila melanogaster Dmel_CG5525   CG5525 gene product from transcript CG5525-RA
Echinococcus granulosus EgrG_000909400   T complex protein 1 subunit delta
Entamoeba histolytica EHI_114120   chaperonin containing TCP-1 delta subunit, putative
Echinococcus multilocularis EmuJ_000909400   T complex protein 1 subunit delta
Giardia lamblia GL50803_17482   TCP-1 chaperonin subunit alpha
Homo sapiens ENSG00000115484   chaperonin containing TCP1, subunit 4 (delta)
Leishmania braziliensis LbrM.21.1320   T-complex protein 1, delta subunit, putative
Leishmania donovani LdBPK_211330.1   T-complex protein 1, delta subunit, putative
Leishmania infantum LinJ.21.1330   T-complex protein 1, delta subunit, putative
Leishmania major LmjF.21.1090   T-complex protein 1, delta subunit, putative
Leishmania mexicana LmxM.21.1090   T-complex protein 1, delta subunit, putative
Loa Loa (eye worm) LOAG_08729   T-complex protein 1
Mus musculus ENSMUSG00000007739   chaperonin containing Tcp1, subunit 4 (delta)
Neospora caninum NCLIV_034530   TCP-1/cpn60 family chaperonin, putative
Oryza sativa 4349108   Os10g0514600
Oryza sativa 4329211   Os02g0332200
Plasmodium berghei PBANKA_1134100   T-complex protein 1 subunit delta, putative
Plasmodium falciparum PF3D7_1357800   T-complex protein 1 subunit delta
Plasmodium knowlesi PKNH_1113700   T-complex protein 1 subunit delta, putative
Plasmodium vivax PVX_114865   T-complex protein 1 subunit delta, putative
Plasmodium yoelii PY02937   chaperonin containing TCP-1 delta subunit
Saccharomyces cerevisiae YDL143W   Cct4p
Schistosoma japonicum Sjp_0013990   ko:K09496 T-complex protein 1 subunit delta, putative
Schistosoma mansoni Smp_004600   chaperonin containing t-complex protein 1 delta subunit tcpd
Schmidtea mediterranea mk4.000655.03   T-complex protein 1 subunit delta
Schmidtea mediterranea mk4.000655.02   T-complex protein 1 subunit delta
Trypanosoma brucei gambiense Tbg972.10.1340   T-complex protein 1, delta subunit, putative
Trypanosoma brucei Tb927.10.1060   T-complex protein 1, delta subunit, putative
Trypanosoma congolense TcIL3000_10_870   T-complex protein 1, delta subunit, putative
Trypanosoma cruzi TcCLB.509695.200   T-complex protein 1, delta subunit, putative
Toxoplasma gondii TGME49_272910   T-complex protein 1 delta subunit
Theileria parva TP01_0241   chaperonin 60 kDa, putative
Trichomonas vaginalis TVAG_137820   chaperonin containing t-complex protein 1, eta subunit, tcph, putative
Trichomonas vaginalis TVAG_066690   chaperonin containing t-complex protein 1, epsilon subunit, tcpe, putative

Essentiality

NCLIV_034530 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.1060 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.1060 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.1060 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.1060 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_K01C8.10 Caenorhabditis elegans embryonic lethal wormbase
CELE_K01C8.10 Caenorhabditis elegans larval arrest wormbase
CELE_K01C8.10 Caenorhabditis elegans slow growth wormbase
CELE_K01C8.10 Caenorhabditis elegans sterile wormbase
YDL143W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1134100 Plasmodium berghei Essential plasmo
TGME49_272910 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Macaaca fascicularis T-complex protein 1 subunit beta 535 aa 31.7% 521 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier NCLIV_034530 (Neospora caninum), TCP-1/cpn60 family chaperonin, putative
Title for this comment
Comment