Detailed view for PF3D7_0909500

Basic information

TDR Targets ID: 4770
Plasmodium falciparum, subpellicular microtubule protein 1, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.2177 | Length (AA): 489 | MW (Da): 56788 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0008017   microtubule binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
99 401 1jl5 (A) 1079 1359 31.00 0.0000052 0.99 0.42 1.76
99 401 1jl5 (A) 1079 1359 31.00 0.00003 0.99 0.524132 0.75
99 441 4ow2 (A) 79 442 31.00 0.0000022 0.51 0.473931 0.89
158 329 4o60 (A) 30 206 27.00 0.95 0.09 0.669238 -0.68
99 334 1jl5 (A) 1079 1276 36.00 0.0065 0.93 0.545709 0.38
128 297 4qfv (A) 32 206 29.00 0.015 0.1 0.74677 -0.44

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile intra-erythrocytic - 24 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile gametocyte, merozoite, late ring, Female Gametocyte. PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile sporozoite, early ring, early schizont, early trophozoite, late schizont, late trophozoite. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Oocyst. Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Ring, Sporozoite, Male Gametocyte. Otto TD Zanghi G Lasonder E
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_134118)

Species Accession Gene Product
Cryptosporidium hominis Chro.70196   similar to protein MGC35182
Cryptosporidium parvum cgd7_1660   STOP repeat protein involved in microtubule stabilization (possible variant metal binding site at N-terminus)
Leishmania braziliensis LbrM.24.2060   hypothetical protein, conserved
Leishmania donovani LdBPK_242060.1   hypothetical protein, conserved
Leishmania infantum LinJ.24.2060   hypothetical protein, conserved
Leishmania major LmjF.24.1980   hypothetical protein, conserved
Leishmania mexicana LmxM.24.1980   hypothetical protein, conserved
Neospora caninum NCLIV_024420   hypothetical protein
Plasmodium berghei PBANKA_0810700   subpellicular microtubule protein 1, putative
Plasmodium falciparum PF3D7_0909500   subpellicular microtubule protein 1, putative
Plasmodium knowlesi PKNH_0707500   subpellicular microtubule protein 1, putative
Plasmodium vivax PVX_135260   unspecified product
Plasmodium vivax PVX_098915   subpellicular microtubule protein 1, putative
Plasmodium yoelii PY03130   repetitive proline rich protein, putative
Schistosoma japonicum Sjp_0036730   expressed protein
Schistosoma mansoni Smp_034680   hypothetical protein
Schmidtea mediterranea mk4.001401.02  
Trypanosoma brucei gambiense Tbg972.8.6300   hypothetical protein, conserved
Trypanosoma brucei Tb927.8.6240   STOP axonemal protein
Trypanosoma congolense TcIL3000_0_45660   STOP axonemal protein
Trypanosoma cruzi TcCLB.511903.190   STOP axonemal protein, putative
Trypanosoma cruzi TcCLB.511065.10   STOP axonemal protein, putative
Toxoplasma gondii TGME49_263520   microtubule associated protein SPM1

Essentiality

PF3D7_0909500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.6240 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.6240 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.6240 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.6240 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0810700 Plasmodium berghei Dispensable plasmo
TGME49_263520 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.4

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PF3D7_0909500 (Plasmodium falciparum), subpellicular microtubule protein 1, putative
Title for this comment
Comment