pI: 6.9679 |
Length (AA): 1373 |
MW (Da): 160373 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 14 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
270 | 468 | 2g9n (A) | 23 | 236 | 20.00 | 0.0000000000094 | 0.96 | 0.44 | -1.32 |
280 | 449 | 1vec (A) | 86 | 270 | 21.00 | 0 | 0.73 | 0.47 | -1.69 |
5 | 174 | 4v3d (C) | 518 | 716 | 15.00 | 0.82 | 0.03 | 0.288016 | -0.55 |
234 | 1372 | 2xgj (A) | 82 | 1073 | 30.00 | 0 | 1 | 0.91737 | 1.05 |
274 | 1372 | 4a4z (A) | 299 | 1287 | 40.00 | 0 | 1 | 0.909937 | 1.02 |
298 | 1372 | 4u4c (A) | 146 | 1073 | 37.00 | 0 | 1 | 0.938457 | 0.76 |
302 | 476 | 3ly5 (A) | 202 | 384 | 27.00 | 0.075 | 0.99 | 0.328958 | -0.21 |
318 | 860 | 4bgd (A) | 516 | 989 | 28.00 | 0.000000000017 | 1 | 0.268984 | 1.28 |
668 | 758 | 3rc3 (A) | 376 | 476 | 34.00 | 0.77 | 0.8 | 0.290778 | 0.67 |
76 | 403 | 4dkj (A) | 61 | 393 | 29.00 | 0.39 | 0.37 | 0.101067 | 1.77 |
234 | 1371 | 2xgj (A) | 82 | 1073 | 29.00 | 0 | 1 | 0.906046 | 1.04 |
274 | 1371 | 4a4z (A) | 299 | 1287 | 40.00 | 0 | 1 | 0.918292 | 1.04 |
282 | 1371 | 4u4c (A) | 130 | 1073 | 31.00 | 0 | 1 | 0.895061 | 0.8 |
1142 | 1361 | 4tql (A) | 11 | 231 | 6.00 | 0.86 | 0.02 | 0.21235 | -0.35 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, Ring. | Otto TD Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst, Sporozoite. | Otto TD Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Female Gametocyte, Male Gametocyte. | Lasonder E |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Ortholog group members (OG5_128384)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G46960 | DExD/H box RNA helicase |
Babesia bovis | BBOV_II002350 | helicase with zinc finger motif protein, putative |
Brugia malayi | Bm1_22815 | helicase |
Candida albicans | CaO19.6425 | antiviral protein, blocks translation of non-poly(A) mRNAs |
Candida albicans | CaO19.13783 | antiviral protein, blocks translation of non-poly(A) mRNAs |
Caenorhabditis elegans | CELE_F01G4.3 | Protein SKIH-2 |
Cryptosporidium hominis | Chro.30042 | DEAD/DEAH box helicase |
Cryptosporidium parvum | cgd3_280 | mRNA translation inhibitor SKI2 SFII helicase, DEXDc+HELICc |
Dictyostelium discoideum | DDB_G0277211 | DEAD/DEAH box helicase |
Drosophila melanogaster | Dmel_CG10210 | twister |
Echinococcus granulosus | EgrG_000462500 | DNA RNA helicase C terminal |
Entamoeba histolytica | EHI_125170 | DEAD/DEAH box helicase, putative |
Echinococcus multilocularis | EmuJ_000462500 | DNA RNA helicase, C terminal |
Homo sapiens | ENSG00000204351 | superkiller viralicidic activity 2-like (S. cerevisiae) |
Loa Loa (eye worm) | LOAG_15949 | hypothetical protein |
Loa Loa (eye worm) | LOAG_13439 | hypothetical protein |
Loa Loa (eye worm) | LOAG_05800 | helicase |
Loa Loa (eye worm) | LOAG_14285 | hypothetical protein |
Mus musculus | ENSMUSG00000040356 | superkiller viralicidic activity 2-like (S. cerevisiae) |
Neospora caninum | NCLIV_014710 | DEAD/DEAH box helicase domain-containing protein, putative |
Plasmodium berghei | PBANKA_0811100 | helicase SKI2W, putative |
Plasmodium falciparum | PF3D7_0909900 | helicase SKI2W, putative |
Plasmodium knowlesi | PKNH_0707900 | helicase SKI2W, putative |
Plasmodium vivax | PVX_098935 | DEAD/DEAH box helicase, putative |
Plasmodium yoelii | PY03503 | antiviral protein ski2 |
Saccharomyces cerevisiae | YLR398C | SKI complex RNA helicase subunit SKI2 |
Schistosoma japonicum | Sjp_0009140 | expressed protein |
Schistosoma mansoni | Smp_137580 | helicase |
Schmidtea mediterranea | mk4.002322.00 | Helicase SKI2W |
Schmidtea mediterranea | mk4.009203.00 | Uncharacterized helicase |
Schmidtea mediterranea | mk4.024587.00 | Helicase SKI2W |
Toxoplasma gondii | TGME49_285660 | DEAD/DEAH box helicase domain-containing protein |
Theileria parva | TP04_0364 | hypothetical protein |
Trichomonas vaginalis | TVAG_432490 | activating signal cointegrator 1 complex subunit 3, helc1, putative |
Trichomonas vaginalis | TVAG_177450 | helicase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_0811100 | Plasmodium berghei | Dispensable | plasmo |
TGME49_285660 | Toxoplasma gondii | Essentiality uncertain | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.