pI: 7.9163 |
Length (AA): 756 |
MW (Da): 84517 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
167 | 285 | 2mqa (A) | 21 | 136 | 15.00 | 0 | 0.01 | 0.217507 | -0.38 |
243 | 640 | 2j0j (A) | 297 | 676 | 21.00 | 0 | 1 | 0.565855 | 0.67 |
343 | 750 | 3mwu (A) | 0 | 449 | 22.00 | 0 | 1 | 0.641083 | 0.25 |
349 | 648 | 2vd5 (A) | 69 | 345 | 22.00 | 0 | 1 | 0.529225 | 0.14 |
357 | 585 | 1ua2 (A) | 18 | 212 | 40.00 | 0.00000000037 | 1 | 0.44771 | 0.58 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_131896)
Species | Accession | Gene Product |
---|---|---|
Babesia bovis | BBOV_III003130 | protein kinase domain containing protein |
Candida albicans | CaO19.8058 | similar to S. cerevisiae IKS1 (YJL057C) kinase suppressor of Ira1 |
Candida albicans | CaO19.428 | similar to S. cerevisiae IKS1 (YJL057C) kinase suppressor of Ira1 |
Cryptosporidium hominis | Chro.70346 | hypothetical protein |
Cryptosporidium parvum | cgd7_3080 | hypothetical protein |
Dictyostelium discoideum | DDB_G0283109 | IKS family protein kinase |
Leishmania braziliensis | LbrM.25.2570 | protein kinase, putative |
Leishmania donovani | LdBPK_251580.1 | protein kinase, putative |
Leishmania infantum | LinJ.25.1580 | protein kinase, putative |
Leishmania major | LmjF.25.1520 | protein kinase, putative |
Leishmania mexicana | LmxM.25.1520 | protein kinase, putative |
Neospora caninum | NCLIV_034010 | Wee kinase, putative |
Saccharomyces cerevisiae | YJL057C | Iks1p |
Trypanosoma brucei gambiense | Tbg972.3.1350 | protein kinase, putative |
Trypanosoma brucei | Tb927.3.1570 | Lapatinib-binding protein kinase 3 |
Trypanosoma congolense | TcIL3000_0_56770 | protein kinase, putative |
Trypanosoma congolense | TcIL3000_3_660 | protein kinase, putative |
Trypanosoma cruzi | TcCLB.510089.80 | protein kinase, putative |
Trypanosoma cruzi | TcCLB.510421.90 | protein kinase, putative |
Toxoplasma gondii | TGME49_273690 | Wee kinase |
Theileria parva | TP04_0139 | serine/threonine protein kinase, putative |
Trichomonas vaginalis | TVAG_258290 | AGC family protein kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.3.1570 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.1570 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.1570 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.3.1570 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_273690 | Toxoplasma gondii | Probably non-essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Sus scrofa | Casein kinase I isoform alpha | 125 aa | 25.9% | 135 aa | Compounds | References |
Rattus norvegicus | cAMP-dependent protein kinase alpha-catalytic subunit | 351 aa | 25.9% | 293 aa | Compounds | References |
Schizosaccharomyces pombe 972h- | Casein kinase II subunit alpha | 332 aa | 25.8% | 275 aa | Compounds | References |
Rattus norvegicus | Serine/threonine-protein kinase pim-3 | 326 aa | 24.7% | 267 aa | Compounds | References |
Bos taurus | cAMP-dependent protein kinase alpha-catalytic subunit | 351 aa | 26.3% | 293 aa | Compounds | References |