Detailed view for PF3D7_0910100

Basic information

TDR Targets ID: 4776
Plasmodium falciparum, exportin-7, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 6.3063 | Length (AA): 1198 | MW (Da): 139178 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0020011   apicoplast  
GO:0005488   binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 1073 2bpt (A) 1 858 11.00 0 1 0.61 -0.12
8 950 1qgr (A) 2 870 11.00 0 1 0.69 -0.62
2 1198 3nc1 (A) 21 1020 12.00 0 1 0.736165 0.81
399 850 3ffz (A) 662 1155 29.00 0.0011 0.21 0.184195 2.54

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite, Oocyst, Ring, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile gametocyte, Sporozoite. PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Female Gametocyte. Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_128385)

Species Accession Gene Product
Arabidopsis thaliana AT5G06120   Importin-beta, N-terminal domain-containing protein
Babesia bovis BBOV_II002360   conserved hypothetical protein
Brugia malayi Bm1_22665   Exportin-like
Caenorhabditis elegans CELE_C35A5.8   Protein C35A5.8
Cryptosporidium hominis Chro.70197   hypothetical protein
Cryptosporidium parvum cgd7_1670   nuclear pore protein RBP16/17 (RAN binding protein 16/17)
Dictyostelium discoideum DDB_G0291986   RAN binding protein 16
Drosophila melanogaster Dmel_CG33180   CG33180 gene product from transcript CG33180-RE
Echinococcus granulosus EgrG_000939900   exportin 7
Entamoeba histolytica EHI_009630   Ran-binding protein, putative
Echinococcus multilocularis EmuJ_000939900   exportin 7
Homo sapiens ENSG00000130227   exportin 7
Homo sapiens ENSG00000204764   RAN binding protein 17
Leishmania braziliensis LbrM.10.1320   hypothetical protein, conserved
Leishmania donovani LdBPK_101300.1   hypothetical protein, conserved
Leishmania infantum LinJ.10.1300   hypothetical protein, conserved
Leishmania major LmjF.10.1200   hypothetical protein, conserved
Leishmania mexicana LmxM.10.1200   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_04067   hypothetical protein
Loa Loa (eye worm) LOAG_10770   hypothetical protein
Mus musculus ENSMUSG00000022100   exportin 7
Mus musculus ENSMUSG00000040594   RAN binding protein 17
Neospora caninum NCLIV_005770   hypothetical protein
Oryza sativa 4333453   Os03g0616700
Plasmodium berghei PBANKA_0811300   exportin-7, putative
Plasmodium falciparum PF3D7_0910100   exportin-7, putative
Plasmodium knowlesi PKNH_0708100   exportin-7, putative
Plasmodium vivax PVX_098945   Ran-binding protein, putative
Plasmodium yoelii PY05488   ran-binding protein 17
Schistosoma japonicum Sjp_0064700   Exportin-7, putative
Schistosoma japonicum Sjp_0084360   Exportin-7, putative
Schistosoma mansoni Smp_105630   hypothetical protein
Schistosoma mansoni Smp_181210   exportin 7-related / ran binding protein 1617
Schistosoma mansoni Smp_115470   exportin 7-related / ran binding protein 1617
Schistosoma mansoni Smp_105620   exportin 7-related / ran binding protein 1617
Schmidtea mediterranea mk4.000477.16  
Schmidtea mediterranea mk4.000477.17  
Trypanosoma brucei gambiense Tbg972.8.4470   hypothetical protein, conserved
Trypanosoma brucei Tb11.v5.0863   hypothetical protein, conserved
Trypanosoma brucei Tb927.8.4660   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_8_4490   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.509573.50   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.503689.40   hypothetical protein, conserved
Toxoplasma gondii TGME49_222380   importin-beta N-terminal domain-containing protein
Theileria parva TP04_0363   hypothetical protein
Trichomonas vaginalis TVAG_113610   conserved hypothetical protein
Trichomonas vaginalis TVAG_062810   conserved hypothetical protein
Trichomonas vaginalis TVAG_489660   conserved hypothetical protein
Trichomonas vaginalis TVAG_303570   conserved hypothetical protein

Essentiality

PF3D7_0910100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.4660 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.4660 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.4660 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.4660 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0811300 Plasmodium berghei Essential plasmo
TGME49_222380 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PF3D7_0910100 (Plasmodium falciparum), exportin-7, putative
Title for this comment
Comment