Detailed view for NCLIV_007290

Basic information

TDR Targets ID: 480354
Neospora caninum, protein kinase, putative
Source Database / ID: 

pI: 9.779 | Length (AA): 978 | MW (Da): 105044 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
51 545 3nyn (A) 103 549 20.00 0 1 0.555735 0.45
106 365 4idt (A) 357 596 29.00 0.0017 1 0.346449 0.55
110 474 2vd5 (A) 38 372 27.00 0 1 0.461811 0.16
112 599 3uzs (A) 155 618 17.00 0 1 0.375578 1.08
136 454 3f3z (A) 23 291 36.00 0 1 0.538776 0.13
137 445 3llt (A) 548 874 22.00 0 1 0.448551 -0.48
137 639 3hx4 (A) 47 483 24.00 0 1 0.564915 0.54
138 356 3b2t (A) 478 694 24.00 0.0079 0.97 0.338526 0.38
167 448 3rp9 (A) 81 403 29.00 0.00000081 1 0.372944 0.01
217 443 4bgq (A) 86 295 33.00 0.000000034 1 0.428706 -0.41
314 366 5j7s (A) 159 230 42.00 0.95 0.46 0.377792 0.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_239409)

Species Accession Gene Product
Neospora caninum NCLIV_007290   protein kinase, putative
Toxoplasma gondii TGME49_275610   protein kinase, other

Essentiality

NCLIV_007290 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_275610 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus MAP kinase p38 alpha 360 aa 25.2% 318 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 26.6% 316 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 25.2% 317 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 8 411 aa 25.1% 379 aa Compounds References
Patiria pectinifera Cdc2 300 aa 24.0% 317 aa Compounds References
Rattus norvegicus c-Jun N-terminal kinase 3 464 aa 23.8% 374 aa Compounds References
Xenopus laevis Aurora kinase B-B 368 aa 23.2% 327 aa Compounds References
Xenopus laevis Aurora kinase B-A 361 aa 23.1% 321 aa Compounds References
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 22.2% 302 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier NCLIV_007290 (Neospora caninum), protein kinase, putative
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