Detailed view for TcCLB.510101.130

Basic information

TDR Targets ID: 48067
Trypanosoma cruzi, inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.7696 | Length (AA): 580 | MW (Da): 63209 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0046856   phosphoinositide dephosphorylation  
GO:0004437   inositol or phosphatidylinositol phosphatase activity  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_131744)

Species Accession Gene Product
Caenorhabditis elegans CELE_C09B8.1   Protein IPP-5
Drosophila melanogaster Dmel_CG42283   CG42283 gene product from transcript CG42283-RB
Homo sapiens ENSG00000068383   inositol polyphosphate-5-phosphatase, 40kDa
Leishmania braziliensis LbrM.11.0810   inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative
Leishmania donovani LdBPK_111010.1   inositol-1,4,5-trisphosphate (IP3) 5- phosphatase, putative
Leishmania infantum LinJ.11.1010   inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative
Leishmania major LmjF.11.1010   inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative
Leishmania mexicana LmxM.11.1010   inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative
Loa Loa (eye worm) LOAG_13479   hypothetical protein
Loa Loa (eye worm) LOAG_15395   hypothetical protein
Loa Loa (eye worm) LOAG_15241   hypothetical protein
Mus musculus ENSMUSG00000025477   inositol polyphosphate-5-phosphatase A
Schmidtea mediterranea mk4.000340.01  
Schmidtea mediterranea mk4.000340.02  
Trypanosoma brucei gambiense Tbg972.11.7070   inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative
Trypanosoma brucei Tb927.11.6270   inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative
Trypanosoma congolense TcIL3000.11.6810   inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative
Trypanosoma cruzi TcCLB.510101.130   inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative
Trypanosoma cruzi TcCLB.506297.200   inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative

Essentiality

TcCLB.510101.130 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.4140 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.4140 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.4140 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.02.4140 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.6

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens inositol polyphosphate-5-phosphatase, 40kDa Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.510101.130 (Trypanosoma cruzi), inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative
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